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TAF6

Official Full Name

Taf6p
Overview

The basal transcription factor TFIID plays a central role in the regulation of gene expression in Eukaryota and is a large protein complex composed of TATA box-binding protein (TBP) and 14 kinds of TBP-associated factors (TAF). TFIID directly recognizes and binds to different kinds of core promoter elements that localize near the transcription initiation site and forms a scaffold for the other basal transcription factors to assemble. At the same time, it transmits transcriptional activation signal originating from transcription regulating factors to RNA polymerase II. Taf6p is one of the subunits of TFIID and in the case of budding yeast, it is composed of 516 amino acid residues (aa). Taf6p is also a subunit of histoneacetylase complex SAGA which is said to have an overlapping function with TFIID. The protein contains histone folds in its interior and forms TAF octamer together with Taf4p, Taf9p and Taf12p.
Synonyms

TAF6; Taf6p; TAF60; NP_011403.1; YGL112C; Eukaryota; Fungi; Ascomycota; Saccharomycotina (true yeasts); Taphrinomycotina; Schizosaccharomycetes (fission yeasts); Basidiomycota; Agaricomycotina; Tremellomycetes; Pucciniomycotina; Microbotryomycetes;

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	TAF6-1267HCL	Recombinant Human TAF6 293 Cell Lysate	HEK293	N/A	Inquiry
Mouse	TAF6-16399M	Recombinant Mouse TAF6 Protein	Mammalian Cell	His	Inquiry
Mouse	TAF6-8970M	Recombinant Mouse TAF6 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	TAF6-8970M-B	Recombinant Mouse TAF6 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Zebrafish	TAF6-1280Z	Recombinant Zebrafish TAF6	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein

TAF6 involved in several pathways and played different roles in them. We selected most pathways TAF6 participated on our site, such as Basal transcription factors, Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with TAF6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Basal transcription factors	TAF5L;TAF4B;TAF1L;GTF2A1L;TAF13;TAF2;MNAT1;TBP;TAF9B
Herpes simplex infection	OAS3;C1QBP;IFNA21;Ifna11;IFNA4;CUL1;PPP1CB;HLA-DPA1;MAPK10

TAF6 has several biochemical functions, for example, DNA binding, protein binding, protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TAF6 itself. We selected most functions TAF6 had, and list some proteins which have the same functions with TAF6. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	ZBTB26;HIST1H2A9;ERCC3;FOXE1;ZNF423;NR6A1A;TIGD6;MEF2CA;EME1
protein binding	SEC24D;BCL2;MAPRE1;TBCB;F11R;COPE;GMPPB;EHD1;PHYH
protein heterodimerization activity	SMAD4;HIST1H2BL;UGT1A6B;UGT1A7;ADORA1;BIK;H2AFZ;DRD1;SMC2
transcription factor activity, sequence-specific DNA binding	ZNF202;NR1D4A;RORC;HOMEZ;MAFG;NFIL3-4;CTNNB1;GRHL2A;MYCN
contributes_to transcription factor activity, sequence-specific DNA binding	MAFGB;NKX2-5;FOXH1;GATA4;TAF10;TAF12;SOX1A;VDRB;VDR

TAF6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TAF6 here. Most of them are supplied by our site. Hope this information will be useful for your research of TAF6.

TBP; E2; E2; pyrF; q8ckw7_yerpe; q8czv1_yerpe; h3_peptide_2-18; MED26; CCNA2; MAPK3; WDR5; H3F3A