|Official Full Name||TATA binding protein|
|Background||General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA.|
|Synonyms||GTF2D,GTF2D1,HDL4,MGC117320,MGC126054,MGC126055,SCA17,TATA binding factor,TATA box factor,TATA sequence binding protein,TATA sequence-binding protein,TATA-binding factor,TATA-box binding protein N-terminal domain,TATA-box factor,TATA-box-binding protein,TBP,TBP_HUMAN,TFIID,Transcription initiation factor TFIID TBP subunit; TATA; binding protein TBP|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
TBP involved in several pathways and played different roles in them. We selected most pathways TBP participated on our site, such as Basal transcription factors, Huntingtons disease, HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with TBP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Basal transcription factors||TAF5L; GTF2I; TAF9; TAF15; TAF12; TAF2; GTF2H3-2; CCNH; TAF5; GTF2B|
|Huntingtons disease||NDUFS8; DNALC1; ATP5E; DNAL4; SLC25A4; COX5A; MT-ATP6; HTT; COX6B1; DNAI2|
|HTLV-I infection||RANBP1; SFPI1; PIK3CB; ANAPC11; PDGFRB; PTTG2; STAT5A; WNT7A; NRAS; CCND2|
|Herpes simplex infection||TNFB; PER1A; HLA-DQA2; HNRPK; TAF5L; CSNK2A2A; CSNK2A2; CASP3A; IFNA3; BLB2|
|Epstein-Barr virus infection||TRAF5; SHFM1; DDX58; POLR2E; MAP2K4; AKAP8L; TP53; HDAC2; IRF3; CD44|
|Viral carcinogenesis||SND1; VAC14; STAT5B; H2-Q10; GTF2B; DNAJA3; HIST1H2BD; TRAF1; HIST1H2BL; HIST1H2BA|
TBP has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II repressing transcription factor binding, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TBP itself. We selected most functions TBP had, and list some proteins which have the same functions with TBP. You can find most of the proteins on our site.
|RNA polymerase II core promoter proximal region sequence-specific DNA binding||TCF3B; T; POU2F3; SNAI3; ETV2; NR5A2; ETV1; MLXIPL; NACC2; FOSB|
|RNA polymerase II repressing transcription factor binding||DMAP1; BBS1; RBPJ; TBP; MKKS; GSC; SP1; MTA1; GTF2A2; MTA2|
|enzyme binding||CNTNAP2; ZFP36; YWHAB; HOXA9; ITGB3; KIAA1967; MDM2; SIRT3; ZFHX3; LDB1|
|protein binding||MICA; MED7; CADM1; ERO1LB; HTR3E; PHF10; SRSF2; TNFRSF10B; EIF4G1; TMEM132D|
|repressing transcription factor binding||CTNNB1; RUNX2; GMNN; EIF4E; DDX20; NFYB; HDAC7; RELA; KAT5; CBX5|
|transcription factor activity, sequence-specific DNA binding||TFCP2; SLC30A9; TAF13; NR4A2A; ZNF561; AHR; L3MBTL4; NR6A1B; ZNF37A; TBX2B|
|transcription factor binding||C1QBP; GNPTAB; PYDC3; PPARG; PARP1; NFIA; EP300; TRIM11; PRICKLE1; TFDP1B|
|transcription regulatory region DNA binding||ATF6B; XRCC6; NKX2-1; MEN1; ATMIN; BCOR; CDK5RAP2; GABPB1; TAL1; GATA6|
TBP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TBP here. Most of them are supplied by our site. Hope this information will be useful for your research of TBP.
lt_sv40; TAF1; TAF5; TAF1B