TBP

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TBP

Official Full Name TATA binding protein
Background General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA.
Synonyms GTF2D,GTF2D1,HDL4,MGC117320,MGC126054,MGC126055,SCA17,TATA binding factor,TATA box factor,TATA sequence binding protein,TATA sequence-binding protein,TATA-binding factor,TATA-box binding protein N-terminal domain,TATA-box factor,TATA-box-binding protein,TBP,TBP_HUMAN,TFIID,Transcription initiation factor TFIID TBP subunit; TATA; binding protein TBP
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TBP-1169H Recombinant Human TATA Box Binding Protein, GST-tagged E.coli GST
    Human TBP-1210HCL Recombinant Human TBP 293 Cell Lysate HEK293 N/A
    Human TBP-30154TH Recombinant Human TBP, His-tagged E.coli His
    Mouse TBP-16517M Recombinant Mouse TBP Protein Mammalian Cell His
    Mouse Tbp-1823M Recombinant Mouse Tbp protein, His & T7-tagged E.coli His/T7
    Cynomolgus Monkey TBP-1005C Recombinant Cynomolgus TBP Protein, His-tagged Mammalian Cell His
    Chicken TBP-6660C Recombinant Chicken TBP Mammalian Cell His
    Zebrafish TBP-10448Z Recombinant Zebrafish TBP Mammalian Cell His

    TBP involved in several pathways and played different roles in them. We selected most pathways TBP participated on our site, such as Basal transcription factors, Huntingtons disease, HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with TBP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Basal transcription factors TAF5L; GTF2I; TAF9; TAF15; TAF12; TAF2; GTF2H3-2; CCNH; TAF5; GTF2B
    Huntingtons disease NDUFS8; DNALC1; ATP5E; DNAL4; SLC25A4; COX5A; MT-ATP6; HTT; COX6B1; DNAI2
    HTLV-I infection RANBP1; SFPI1; PIK3CB; ANAPC11; PDGFRB; PTTG2; STAT5A; WNT7A; NRAS; CCND2
    Herpes simplex infection TNFB; PER1A; HLA-DQA2; HNRPK; TAF5L; CSNK2A2A; CSNK2A2; CASP3A; IFNA3; BLB2
    Epstein-Barr virus infection TRAF5; SHFM1; DDX58; POLR2E; MAP2K4; AKAP8L; TP53; HDAC2; IRF3; CD44
    Viral carcinogenesis SND1; VAC14; STAT5B; H2-Q10; GTF2B; DNAJA3; HIST1H2BD; TRAF1; HIST1H2BL; HIST1H2BA

    TBP has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II repressing transcription factor binding, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TBP itself. We selected most functions TBP had, and list some proteins which have the same functions with TBP. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II core promoter proximal region sequence-specific DNA binding TCF3B; T; POU2F3; SNAI3; ETV2; NR5A2; ETV1; MLXIPL; NACC2; FOSB
    RNA polymerase II repressing transcription factor binding DMAP1; BBS1; RBPJ; TBP; MKKS; GSC; SP1; MTA1; GTF2A2; MTA2
    enzyme binding CNTNAP2; ZFP36; YWHAB; HOXA9; ITGB3; KIAA1967; MDM2; SIRT3; ZFHX3; LDB1
    protein binding MICA; MED7; CADM1; ERO1LB; HTR3E; PHF10; SRSF2; TNFRSF10B; EIF4G1; TMEM132D
    repressing transcription factor binding CTNNB1; RUNX2; GMNN; EIF4E; DDX20; NFYB; HDAC7; RELA; KAT5; CBX5
    transcription factor activity, sequence-specific DNA binding TFCP2; SLC30A9; TAF13; NR4A2A; ZNF561; AHR; L3MBTL4; NR6A1B; ZNF37A; TBX2B
    transcription factor binding C1QBP; GNPTAB; PYDC3; PPARG; PARP1; NFIA; EP300; TRIM11; PRICKLE1; TFDP1B
    transcription regulatory region DNA binding ATF6B; XRCC6; NKX2-1; MEN1; ATMIN; BCOR; CDK5RAP2; GABPB1; TAL1; GATA6

    TBP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TBP here. Most of them are supplied by our site. Hope this information will be useful for your research of TBP.

    lt_sv40; TAF1; TAF5; TAF1B

    Jackisch, C; Welslau, M; et al. Impact of trastuzumab treatment beyond disease progression for advanced/metastatic breast cancer on survival - Results from a prospective, observational study in Germany. BREAST 23:603-608(2014).
    Voss, C; Schmitt, B; et al. A novel, non-radioactive eukaryotic in vitro transcription assay for sensitive quantification of RNA polymerase II activity. BMC MOLECULAR BIOLOGY 15:-(2014).

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