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TBX1

  • Official Full Name

    T-box 1

  • Overview

    This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product shares 98% amino acid sequence identity with the mouse ortholog. DiGeorge syndrome (DGS)/velocardiofacial syndrome (VCFS), a common congenital disorder characterized by neural-crest-related developmental defects, has been associated with deletions of chromosome 22q11.2, where this gene has been mapped. Studies using mouse models of DiGeorge syndrome suggest a major role for this gene in the molecular etiology of DGS/VCFS. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms

    TBX1; T-box 1; DGS; TGA; VCF; CAFS; CTHM; DGCR; DORV; VCFS; TBX1C; CATCH22; T-box transcription factor TBX1; brachyury; Testis-specific T-box protein; T-box 1 transcription factor C;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TBX1-5465H Recombinant Human TBX1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TBX1-415H Recombinant Human TBX1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Mouse Tbx1-6318M Recombinant Mouse Tbx1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Zebrafish TBX1-9699Z Recombinant Zebrafish TBX1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

TBX1 involved in several pathways and played different roles in them. We selected most pathways TBX1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TBX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

TBX1 has several biochemical functions, for example, DNA binding, protein binding, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TBX1 itself. We selected most functions TBX1 had, and list some proteins which have the same functions with TBX1. You can find most of the proteins on our site.

Function Related Protein
DNA bindingIER2;PRDM4;CRSP7;AHR;NCOR2;FLI1B;SOX19B;ARID3C;ZNF671
protein bindingKRAS;PIK3R2;MPLKIP;STX10;RYR1B;FBL;TMEM199;PINX1;PPIAL4A
protein homodimerization activityECE1;ATPIF1A;SLC14A2;TREX2;GCH1;LSM1;ADIPOQ;NRF1;CSF1
sequence-specific DNA bindingETV5B;TSN;GATA5;DBX2;NKX6.2;MNX1;ZSCAN23;GRHL2A;HOXD13A
transcription factor activity, sequence-specific DNA bindingHOXC4A;PLAGL2;ZNF311;RORC;DBPB;HMG20A;GATA2;FOXM1;GCM2

TBX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TBX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TBX1.

Research Area

Related articles

Liu, NM; Yokota, T; et al. Transcription Profiles of Endothelial Cells in the Rat Ductus Arteriosus during a Perinatal Period. PLOS ONE 8:-(2013).
Kimura, W; Sharkar, MTK; et al. Generation and characterization of Tbx1-AmCyan1 transgenic reporter mouse line that selectively labels developing thymus primordium. TRANSGENIC RESEARCH 22:659-666(2013).
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