TCF7L2

  • Official Full Name

    transcription factor 7-like 2 (T-cell specific, HMG-box)
  • Overview

    This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.
  • Synonyms

    TCF7L2;transcription factor 7-like 2 (T-cell specific, HMG-box);TCF4;transcription factor 7-like 2;TCF 4;hTCF-4;T-cell factor 4;T-cell factor-4 variant A;T-cell factor-4 variant B;T-cell factor-4 variant C;T-cell factor-4 variant D;T-cell facto
Cat.# Product name Source (Host) Species Tag Protein Length Price
TCF7L2-3308H Recombinant Human TCF7L2 protein, His-tagged E.coli Human His 1-355 aa
TCF7L2-4511C Recombinant Chicken TCF7L2 Mammalian Cells Chicken His
TCF7L2-8855Z Recombinant Zebrafish TCF7L2 Mammalian Cells Zebrafish His
TCF7L2-1177HCL Recombinant Human TCF7L2 293 Cell Lysate HEK293 Human Non
TCF7L2-2068H Recombinant Human TCF7L2 Protein (1-456 aa), His-tagged E.coli Human His 1-456 aa

    Involved Pathway

    TCF7L2 involved in several pathways and played different roles in them. We selected most pathways TCF7L2 participated on our site, such as Wnt signaling pathway,Hippo signaling pathway,Adherens junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TCF7L2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Wnt signaling pathway WNT5A,CAMK2D,FZD8,MAPK10,AXIN1,EP300,CER1,WNT2BB,BAMBIB,WNT11
    Adherens junction SMAD3,ACTN3,ACTB,RAC1A,PVRL1B,CDC42L2,TCF7,MAPK1,ACTN1,CTNNB1
    Pathways in cancer STAT3,PRKCA,MMP2,PIK3R1,TRAF1,NFKB2,HSP90AB1,PTGER1,LAMC2,FGF10
    Prostate Cancer CREB3L2,PIK3CD,PIK3CG,NOXA1,NRAS,CREB3L1,SPINK1,PIK3R2,HSP90AA1,AKT2
    Hippo signaling pathway PPP2R2D,SMAD3,WNT8A,BMPR2,PARD6A,FZD7,CCND1,AXIN2,WNT10B,PARD6B
    Thyroid cancer CCDC6,RXRB,TP53,MAPK3,MAP2K2,TPM3,TFG,NCOA4,MAPK1,NTRK1
    Colorectal cancer MAPK10,PIK3R3,SMAD3,AKT2,TGFBR2,BAD,MLH1,CCND1,MSH6,AXIN2
    Melanogenesis FZD7,Fzd4,CALM2A,FZD3B,TCF7,FZD8,PLCB4,WNT7A,CREB1A,MITF
    Acute myeloid leukemia HRAS,PIK3CG,PPARD,AKT2,CHUK,MYC,PIK3R3,PIK3R5,PIM1,IKBKB

    Protein Function

    TCF7L2 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,RNA polymerase II core promoter sequence-specific DNA binding,RNA polymerase II repressing transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TCF7L2 itself. We selected most functions TCF7L2 had, and list some proteins which have the same functions with TCF7L2. You can find most of the proteins on our site.

    Function Related Protein
    sequence-specific DNA binding TFAP2B,FOXJ1B,BCL11B,MEOX1,IRX3B,LHX6,RORB,ZNF165,FOXP1,IRX3A
    chromatin binding MNT,TMPOA,APTX,ATOH1A,NSBP1,JMJD5,ATXN7,DLX3,PBRM1L,CBX1
    RNA polymerase II repressing transcription factor binding MTA1,GTF2A2,BBS10,MKKS,PPARA,DMAP1,TBX5A,HDAC1,BBS4,BBS7
    armadillo repeat domain binding AXIN2,STRN4,AXIN1,CALCOCO1,LEF1,STRN,CHD8,CTNNBIP1,CNOT1
    transcription factor activity, sequence-specific DNA binding ATF6,FOXA,EHF,ZNF263,MYF6,SIM1B,REST,ZSCAN12,MKL1,TEAD2
    protein kinase binding ITGB1BP1,CDC25C,TRIB3,BCL10,IKBKB,FAM83B,GRB2,KIF11,STK11IP,PIFO
    gamma-catenin binding DSG1A,APC,PTBP3,LEF1,PTPRJ,CDH2,DSG1,Fert2,PTPRK,APC2
    beta-catenin binding BCL9L,BCL9,DVL3,LZTS2A,VCL,CHD8,PTPRJ,PROP1,RORA,GSK3B
    transcription regulatory region DNA binding ARID4A,OVOL2,ZFP335,CARM1,MTERFD1,ATMIN,TAL1,CDK9,HINFP,ERBB4

    Interacting Protein

    TCF7L2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TCF7L2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TCF7L2.

    CTNNB1

    Resources

    References

    • Rulifson, IC; Majeti, JZ; et al. Inhibition of secreted frizzled-related protein 5 improves glucose metabolism. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 307:E1144-E1152(2014).
    • Andersen, MK; Harkonen, T; et al. Zinc transporter type 8 autoantibodies (ZnT8A): prevalence and phenotypic associations in latent autoimmune diabetes patients and patients with adult onset type 1 diabetes. AUTOIMMUNITY 46:251-258(2013).

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