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Official Full Name tyrosyl-DNA phosphodiesterase 2
Background This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors.
Synonyms EAP2; AD022; TTRAP; MGC9099; dJ30M3.3; MGC111021; RP1-30M3.3; tyrosyl-DNA phosphodiesterase 2; EAPII; OTTHUMP00000016091; OTTHUMP00000016092; ETS1-associated protein 2; ETS1-associated protein II; tyr-DNA phosphodiesterase 2; 5"-Tyr-DNA phosphodiesterase; 5"-tyrosyl-DNA phosphodiesterase; TRAF and TNF receptor associated protein; TRAF and TNF receptor-associated protein; TDP2; tyrosyl-DNA phosphodiesterase 2
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TDP2-664HCL Recombinant Human TTRAP 293 Cell Lysate HEK293 N/A
    Human TDP2-6706H Recombinant Human TDP2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human TDP2-7580H Recombinant Human TDP2, His-tagged E.coli His
    Mouse TDP2-16603M Recombinant Mouse TDP2 Protein Mammalian Cell His
    Mouse Tdp2-6348M Recombinant Mouse Tdp2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat TDP2-5999R Recombinant Rat TDP2 Protein Mammalian Cell His
    Chicken TDP2-4713C Recombinant Chicken TDP2 Mammalian Cell His

    tdp2 involved in several pathways and played different roles in them. We selected most pathways tdp2 participated on our site, such as CD40/CD40L signaling, DNA Double-Strand Break Repair, DNA Repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with tdp2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    CD40/CD40L signaling MYC; TDP2; JAK3
    DNA Double-Strand Break Repair GEN1; RIF1; CHEK1; TIMELESS; PPP4CA; RAD9; CHEK2; BRE; EME1; RAD1
    Nonhomologous End-Joining (NHEJ) TDP2B; PAXIP1; TDP1; RIF1; TDP2

    tdp2 has several biochemical functions, for example, 5-tyrosyl-DNA phosphodiesterase activity, magnesium ion binding, manganese ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by tdp2 itself. We selected most functions tdp2 had, and list some proteins which have the same functions with tdp2. You can find most of the proteins on our site.

    Function Related Protein
    5-tyrosyl-DNA phosphodiesterase activity TDP2; TDP2B
    magnesium ion binding ALPP; TSSK1; PGM2; SERPINB1A; PPM1NB; EYA2; SRPK1; NEK6; DYRK2; SIK2
    manganese ion binding ARG1; PPM1M; FAM20C; GALNT3; PCK1; ME1; PPM1BB; MTPAP; ABL1; PPM1NB
    nuclease activity REXO1; MRE11A; DOM3Z; ENDOG; ASTE1; DNASE2A; FANCM; TDP2; EXOG; TMPPE
    protein binding RRAGC; TIMM21; NUS1; COL1A1; GNB5; CDK18; CADPS; NUDT18; FAM54B; C7orf59
    single-stranded DNA binding PURB; CRY2; RAD51L1; NME2; PMS1; FBXO18; ANXA1; HMGB2; MEIOB; NCL
    transcription corepressor activity JAZF1; BCL11A; E2F6; HIRA; TBL1Y; HIF3A; KCNIP3; DMAP1; NR1H4; CCND1
    tyrosyl-RNA phosphodiesterase activity TDP2

    tdp2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with tdp2 here. Most of them are supplied by our site. Hope this information will be useful for your research of tdp2.

    SRPK2; DLX3; SKIL; ETS1; PSEN1; ATXN1; JAM2; RAB11A; SMAD3; TAP1; ATP5G2; EPS8; MAPK6; q81xc2_bacan; AKAP9; C2orf88; SNX13

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