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TENC1

Official Full Name

tensin like C1 domain containing phosphatase (tensin 2)
Overview

The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.
Synonyms

TENC1; tensin like C1 domain containing phosphatase (tensin 2); tensin like C1 domain containing phosphatase; tensin-like C1 domain-containing phosphatase; C1 TEN; KIAA1075; tensin 2; TNS2; tensin-2; tensin like C1 domain-containing phosphatase; C1 domain;

Species	Cat.#	Product name	Source (Host)	Tag	Price
Mouse	TENC1-16638M	Recombinant Mouse TENC1 Protein	Mammalian Cell	His	Inquiry
Mouse	TENC1-9126M-B	Recombinant Mouse TENC1 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Mouse	TENC1-9126M	Recombinant Mouse TENC1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry

Involved Pathway
Protein Function
Interacting Protein
TENC1 Related Articles

TENC1 involved in several pathways and played different roles in them. We selected most pathways TENC1 participated on our site, such as PodNet: protein-protein interactions in the podocyte, XPodNet - protein-protein interactions in the podocyte expanded by STRING, which may be useful for your reference. Also, other proteins which involved in the same pathway with TENC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
PodNet: protein-protein interactions in the podocyte	FRAS1;DDN;FAM65A;SDK1;CMIP;LIMS2;TENC1
XPodNet - protein-protein interactions in the podocyte expanded by STRING	TENC1;ATP9A;CLNK;Siglece;SLC6A2;Ighg;PKD1;DDN;GIMAP3

TENC1 has several biochemical functions, for example, 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity, IDP phosphatase activity, JUN kinase phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TENC1 itself. We selected most functions TENC1 had, and list some proteins which have the same functions with TENC1. You can find most of the proteins on our site.

Function	Related Protein
5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity	SACM1LB;CTDSPL2A;SACM1LA;SACM1L;TENC1;NT5DC3;PTPRQ;SGPP2;PXYLP1
IDP phosphatase activity	NT5DC3;TENC1;CTDSPL2B;CTDSPL2A;PTPRQ;SGPP2;SACM1LA;SACM1L;PXYLP1
JUN kinase phosphatase activity	DUSP19;SGPP2;PTPRQ;CTDSPL2A;TENC1;PXYLP1;CTDSPL2B;SACM1L;NT5DC3
MAP kinase tyrosine/serine/threonine phosphatase activity	SGPP2;SACM1LA;TENC1;SACM1LB;DUSP10;SACM1L;DUSP14;DUSP8A;DUSP4
NADP phosphatase activity	TENC1;SACM1LB;SGPP2;PTPRQ;PXYLP1;SACM1LA;SACM1L;CTDSPL2A;CTDSPL2B
hydrolase activity	CHD6;ESPL1;ATP2B3B;ENPP2;DCP1B;ATP8B1;Acr;NOTUM1B;PEO1
inositol bisphosphate phosphatase activity	PXYLP1;PTPRQ;INPP5K;NT5DC3;TENC1;CTDSPL2A;SGPP2;SACM1L;CTDSPL2B
inositol phosphate phosphatase activity	TENC1;NT5DC3;SACM1LB;SGPP2;SACM1L;PXYLP1;PTPRQ;OCRL;CTDSPL2A
inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity	CTDSPL2A;NT5DC3;SGPP2;CTDSPL2B;PXYLP1;SACM1LB;SACM1L;ITPK1;SACM1LA
inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity	PXYLP1;CTDSPL2A;PTPRQ;SACM1L;SGPP2;TENC1;CTDSPL2B;SACM1LB;NT5DC3
inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity	NT5DC3;TENC1;CTDSPL2B;SACM1L;PXYLP1;ITPK1;SACM1LA;CTDSPL2A;PTPRQ
inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity	SACM1L;PTPRQ;TENC1;SACM1LB;CTDSPL2B;NT5DC3;PXYLP1;SACM1LA;CTDSPL2A
inositol-1,3,4-trisphosphate 1-phosphatase activity	PXYLP1;SACM1L;SGPP2;TENC1;SACM1LB;SACM1LA;CTDSPL2A;CTDSPL2B;NT5DC3
inositol-1,3,4-trisphosphate 4-phosphatase activity	SACM1LB;PTPRQ;SACM1LA;PXYLP1;CTDSPL2B;NT5DC3;SGPP2;SACM1L;CTDSPL2A
inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity	CTDSPL2B;PXYLP1;PTPRQ;CTDSPL2A;NT5DC3;SGPP2;SACM1LA;SACM1LB;SACM1L
inositol-3,4-bisphosphate 4-phosphatase activity	TENC1;CTDSPL2B;PTPRQ;PXYLP1;SACM1LB;SGPP2;SACM1LA;NT5DC3;CTDSPL2A
inositol-4,5-bisphosphate 5-phosphatase activity	PTPRQ;CTDSPL2A;TENC1;SACM1LB;PXYLP1;CTDSPL2B;NT5DC3;SACM1L;SGPP2
kinase binding	CHP1;PIP5K1A;RASGRP3;SLC2A1;SGOL1;PRDX3;HPCA;STUB1;ABI2
metal ion binding	ZBTB43;FOXP1B;PHF2;ZNF287;GFI1AB;PDE5A;ISG20;SAP30;SPATA21
phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity	PXYLP1;SACM1LA;SGPP2;NT5DC3;TENC1;SACM1LB;CTDSPL2B;SACM1L;CTDSPL2A
phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	MTM1;TENC1;SACM1L;SACM1LA;SGPP2;MTMR1A;MTMR8;SACM1LB;PTPRQ
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity	PTPRQ;CTDSPL2A;TENC1;SACM1LA;SGPP2;PXYLP1;FIG4;CTDSPL2B;PIKFYVE
phosphatidylinositol-4-phosphate phosphatase activity	SGPP2;SACM1L;TENC1;NT5DC3;PXYLP1;CTDSPL2B;SACM1LA;PTPRQ;SACM1LB
phosphohistidine phosphatase activity	LHPP;PHPT1;CTDSPL2B;NT5DC3;TENC1;SACM1L;SACM1LB;CTDSPL2A;MINPP1
phosphoprotein phosphatase activity	PPM1BB;SSH1;MTM1;CPPED1;PPTC7;CDC14AA;PTPN11A;PPM1H;DUSP28
protein kinase binding	PPP1CB;STX1B;FAM83B;CNPPD1;EMP2;IKBKB;PFKFB2;RAD9A;DPYSL2
protein tyrosine/serine/threonine phosphatase activity	DUSP19B;CDC14AA;SGPP2;DUSP5;CTDSPL2A;DUSP14;CDC14C;SSH2B;CDC14A
protein tyrosine/threonine phosphatase activity	DUSP4;SACM1LB;PTPRQ;DUSP19;SGPP2;SACM1L;DUSP2;NT5DC3;DUSP1
receptor binding	NXPH1;TNFSF18;EHHADH;CADM1A;Ren1;CTNND1;CAT;MSTN;TNFSF15
transmembrane receptor protein phosphatase activity	SGPP2;NT5DC3;TENC1;SACM1LB;PXYLP1;SACM1LA;CTDSPL2A;SACM1L;CTDSPL2B

TENC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TENC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TENC1.

Ywhae

Karere, GM; Glenn, JP; et al. Identification of candidate genes encoding an LDL-C QTL in baboons. JOURNAL OF LIPID RESEARCH 54:1776-1785(2013).

Uchio-Yamada, K; Sawada, K; et al. Tenc1-Deficient Mice Develop Glomerular Disease in a Strain-Specific Manner. NEPHRON EXPERIMENTAL NEPHROLOGY 123:22-33(2013).

Dieterich, LC; Mellberg, S; et al. Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF-A and TGF beta 2 in vascular abnormalization. JOURNAL OF PATHOLOGY 228:378-390(2012).

Chen, LH; Liu, CD; et al. H-1, N-15 and C-13 chemical shift assignments of the SH2 domain of human tensin2 (TENC1). BIOMOLECULAR NMR ASSIGNMENTS 5:211-214(2011).