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TESK2

  • Official Full Name

    testis-specific kinase 2

  • Overview

    This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). Its overall structure is most related to the former, indicating that it belongs to the TESK subgroup of the LIMK/TESK family of protein kinases. This gene is predominantly expressed in testis and prostate. The developmental expression pattern of the rat gene in testis suggests an important role for this gene in meitoic stages and/or early stages of spermiogenesis.
  • Synonyms

    TESK2; testis-specific kinase 2; dual specificity testis-specific protein kinase 2; testicular protein kinase 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Sf9 Insect Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TESK2-252H Active Recombinant Human TESK2, GST-tagged Sf9 Insect Cell GST
Human TESK2-3183H Recombinant Human TESK2, His-tagged E.coli His 190-542aa
Human TESK2-1761HCL Recombinant Human TESK2 cell lysate N/A
Mouse Tesk2-6362M Recombinant Mouse Tesk2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Tesk2-2122M Recombinant Mouse Tesk2 Protein, His-tagged E.coli N-His Asp58-Met313
Rat TESK2-6017R Recombinant Rat TESK2 Protein Mammalian Cell His
Rat TESK2-5676R Recombinant Rat TESK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat TESK2-5676R-B Recombinant Rat TESK2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque TESK2-4669R Recombinant Rhesus monkey TESK2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque TESK2-4485R Recombinant Rhesus Macaque TESK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque TESK2-4485R-B Recombinant Rhesus Macaque TESK2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish TESK2-6196Z Recombinant Zebrafish TESK2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TESK2 Related Articles

TESK2 involved in several pathways and played different roles in them. We selected most pathways TESK2 participated on our site, such as Focal Adhesion, Regulation of Microtubule Cytoskeleton, which may be useful for your reference. Also, other proteins which involved in the same pathway with TESK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Focal AdhesionITGB3B;ITGA2;VTN;HRASA;MAPK8A;MYLK2;PAK6;SRMS;ITGA7
Regulation of Microtubule CytoskeletonCFL2;MARK2;MARK1;TESK2;TPPP;DPYSL2;MAP1B

TESK2 has several biochemical functions, for example, ATP binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TESK2 itself. We selected most functions TESK2 had, and list some proteins which have the same functions with TESK2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingDDX58;UBE2L3B;ENTPD8;MAP3K15;SBK3;P2RX5;DDX5;IGF1RA;LIG3
metal ion bindingGIT1;DICER1;ZSCAN18;CYP2AD3;UBA5;NRXN1B;FTH1A;ARHGEF28;LNPA
protein bindingNMU;PTPN11;ENG;RARB;SGK3;GBF1;KCNJ4;KIF1C;FABP2
protein kinase activityEPHB2B;SBK1;LIMK1A;PKDCC;SCYL1;GC2;PRKAG1;NEK5;TSSK1
protein serine/threonine kinase activityNEK1;STK24;SGK2;GM711;BMPR1B;ZNF143B;SGK2B;GAK;LRRK1
protein serine/threonine/tyrosine kinase activityDYRK4;MAP2K2;DYRK2;SGK1;RPS6KB1;CLK2;AURKB;MAP2K1;RPS6KA2
protein tyrosine kinase activityFGFR1A;IGF1RB;MATK;CLK4;MAP2K7;PTK2AB;CLK2;SRC;TESK2

TESK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TESK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TESK2.

HSP90AB1; linkable pd173955 analogue; bosutinib

Jha, KN; Coleman, AR; et al. Heat Shock Protein 90 Functions to Stabilize and Activate the Testis-specific Serine/Threonine Kinases, a Family of Kinases Essential for Male Fertility. JOURNAL OF BIOLOGICAL CHEMISTRY 288:16308-16320(2013).
Motiei, M; Tavalaee, M; et al. Evaluation of HSPA2 in fertile and infertile individuals. ANDROLOGIA 45:66-72(2013).
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