tfb1m Protein, transcription factor B1, mitochondrial


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Official Full Name transcription factor B1, mitochondrial
Background The protein encoded by this gene is a dimethyltransferase that methylates the conserved stem loop of mitochondrial 12S rRNA. The encoded protein also is part of the basal mitochondrial transcription complex and is necessary for mitochondrial gene expression. The methylation and transcriptional activities of this protein are independent of one another. Variations in this gene may influence the severity of aminoglycoside-induced deafness (AID).
Synonyms TFB1M; transcription factor B1, mitochondrial; dimethyladenosine transferase 1, mitochondrial; CGI 75; dimethyladenosine transferase 1; mitochondrial; mtTFB; hmtTFB; hmtTFB1; hTFB1M; Mitochondrial 12S rRNA dimethylase 1; Mitochondrial transcription factor B1; mtTFB1; h-mtTFB; h-mtTFB1; Mitochondrial dimethyladenosine transferase 1; TFB1M_HUMAN; Transcription factor B1 mitochondrial; homolog of yeast mitochondrial transcription factor B; S-adenosylmethionine-6-N, N-adenosyl(rRNA) dimethyltransferase 1; CGI75; CGI-75
    • Species :
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Human
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TFB1M-1136HCL Recombinant Human TFB1M 293 Cell Lysate HEK293 N/A
    Human TFB1M-1785H Recombinant Human Transcription Factor B1, Mitochondrial, His-tagged Human His
    Human TFB1M-3194H Recombinant Human TFB1M, GST-tagged E.coli GST
    Human TFB1M-3619H Recombinant Human TFB1M, His-tagged E.coli His
    Mouse TFB1M-16682M Recombinant Mouse TFB1M Protein Mammalian Cell His
    Rat TFB1M-6025R Recombinant Rat TFB1M Protein Mammalian Cell His
    Cynomolgus Monkey TFB1M-1016C Recombinant Cynomolgus TFB1M Protein, His-tagged Mammalian Cell His
    Rhesus Macaque TFB1M-4676R Recombinant Rhesus monkey TFB1M Protein, His-tagged Mammalian Cell His
    Zebrafish TFB1M-4594Z Recombinant Zebrafish TFB1M Mammalian Cell His

    tfb1m involved in several pathways and played different roles in them. We selected most pathways tfb1m participated on our site, such as Energy Metabolism, Mitochondrial Gene Expression, Mitochondrial biogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with tfb1m were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Energy Metabolism GABPA; TFB1M; PPARGC1B; MEF2B; MYBBP1A; ESRRA; UCP2; TFB2M; UCP3
    Mitochondrial Gene Expression TFB2M; POLRMT; ESRRA; TFB1M; MTERFD1; PPRC1; PPARGC1B
    Mitochondrial biogenesis PPARGC1B; POLRMT; ESRRA; PPRC1; GABPA; C10orf2; GABPB1; POLG2; TFB1M; MTERF
    Organelle biogenesis and maintenance IQCB1; IFT80; EXOC5; IFT74; DYNLL2A; TTC30B; MRPL48; KIF3CB; CEP97; MRPS34
    Transcriptional activation of mitochondrial biogenesis PPRC1; MTERF; POLRMT; TFB1M; GABPA; GABPB1; POLG2; C10orf2

    tfb1m has several biochemical functions, for example, DNA binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by tfb1m itself. We selected most functions tfb1m had, and list some proteins which have the same functions with tfb1m. You can find most of the proteins on our site.

    Function Related Protein
    poly(A) RNA binding SREK1; ZFML; HMGN2; TCOF1; CFAP20; PEG10; MRPS7; RPL4; PSMD4; LUC7L2
    protein binding LTBP2; PPIE; NAV1; VPS72; TRPV5; CDIPT; CCNB1; IP6K2; HSFX1; GPN3
    rRNA (adenine-N6,N6-)-dimethyltransferase activity PRMT8B; METTL23; TRMT10B; DIMT1L; TFB1M; FAM86; NDUFAF5; TRMT10C; METTL7B; PRDM13

    tfb1m has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with tfb1m here. Most of them are supplied by our site. Hope this information will be useful for your research of tfb1m.

    TFAM; s-adenosyl-l-methionine-1; POLRMT; Srp72; AP4M1; RPL10; YWHAH; ICT1; Rpl35; BAIAP2

    Nabokina, SM; Valle, JE; et al. Characterization of the human mitochondrial thiamine pyrophosphate transporter SLC25A19 minimal promoter: A role for NF-Y in regulating, basal transcription. GENE 528:248-255(2013).

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