Description : |
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. This protein is involved in embryogenesis and cell differentiation, and may play a role in wound healing. Mutations in this gene are a cause of aortic aneurysms and dissections, as well as familial arrhythmogenic right ventricular dysplasia 1. |
Source : |
Mammalian cells |
Species : |
Human |
Tag : |
Flag |
Form : |
25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : |
44.7 kDa |
AA Sequence : |
MKMHLQRALVVLALLNFATVSLSLS TCTTLDFGHIKKKRVEAIRGQILSK LRLTSPPEPTVMTHVPYQVL ALYNSTRELLEEMHGEREEGCTQEN TESEYYAKEIHKFDMIQGLAEHNEL AVCPKGITSKVFRFNVSSVE KNRTNLFRAEFRVLRVPNPSSKRNE QRIELFQILRPDEHIAKQRYIGGKN LPTRGTAEWLSFDVTDTVRE WLLRRESNLGLEISIHCPCHTFQPN GDILENIHEVMEIKFKGVDNEDDHG RGDLGRLKKQKDHHNPHLIL MMIPPHRLDNPGQGGQRKKRALDTN YCFRNLEENCCVRPLYIDFRQDLGW KWVHEPKGYYANFCSGPCPY LRSADTTHSTVLGLYNTLNPEASAS PCCVPQDLEPLTILYYVGRTPKVEQ LSNMVVKSCKCS TRTRPLEQKLISEEDLAANDILDYK DDDDKV |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : |
Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : |
Store at -80 centigrade. |
Concentration : |
>50 ug/mL as determined by microplate BCA method. |
Preparation : |
Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Protein Families : |
Druggable Genome, Secreted Protein, Transmembrane |
Protein Pathways : |
Cell cycle, Chronic myeloid leukemia, Colorectal cancer, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM), MAPK signaling pathway, Pancreatic cancer, Pathways in cancer, Renal cell carcinoma, TGF-beta signaling pathway |