| Species : |
Bovine |
| Source : |
HEK293 |
| Tag : |
His |
| Protein Length : |
341-452aa |
| Description : |
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. This protein is involved in embryogenesis and cell differentiation, and may play a role in wound healing. Mutations in this gene are a cause of aortic aneurysms and dissections, as well as familial arrhythmogenic right ventricular dysplasia 1. |
| Tag : |
C-His |
| Bio-activity : |
The ED(50) was determined by the ability to inhibit the proliferation of mouse HT-2 cells 0.05-0.1 ng/mL, corresponding to a specific activity of 2×10^7 units/mg. |
| Molecular Mass : |
13-15 kDa |
| Endotoxin : |
Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/μg (1 EU/μg). |
| Purity : |
> 95%, as determined by SDS-PAGE and HPLC |
| Usage : |
This product is for research purposes only. It may not be used for therapeutics or diagnostic purposes. |
| Storage : |
The lyophilized protein is stable for at least 2 years from date of receipt at -20 centigrade. |
| Storage Buffer : |
Lyophilized from 0.2 μm filtered PBS solution pH7.4 |
| Reconstitution : |
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. |
