Recombinant Human TGFB3 Protein

• Cat.No.: TGFB3-38H
• Product Overview: Recombinant human TGF-β3 protein without tag was expressed in E. coli.
  Animal-free (AOF) and carrier protein-free.
  Mass spectrometry: single species with expected mass.
  Recovery from stock vial: >95%

Specification

• Species: Human
• Source: E.coli
• Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. This protein is involved in embryogenesis and cell differentiation, and may play a role in wound healing. Mutations in this gene are a cause of aortic aneurysms and dissections, as well as familial arrhythmogenic right ventricular dysplasia 1.
• Molecular Mass: 12.7 kDa monomer, 25.4 kDa dimer
• Endotoxin: <0.005 EU/μg protein (below level of detection)
• Applications: Chemically defined media for organoid culture
• Storage: Resuspend in 10mM HCl (Reconstitution solution A) at >100 μg/mL, prepare single use aliquots, add carrier protein if desired and store frozen at -20 or -80 centigrade
• Storage Buffer: Lyophilized from acetonitrile, TFA

Gene Information

• Gene Name: TGFB3 transforming growth factor beta 3 [ Homo sapiens (human) ]
• Official Symbol: TGFB3
• Synonyms: TGFB3; transforming growth factor beta 3; ARVD; LDS5; RNHF; ARVD1; TGF-beta3; transforming growth factor beta-3 proprotein; prepro-transforming growth factor beta-3
• Gene ID: 7043
• mRNA Refseq: NM_001329938
• Protein Refseq: NP_001316867
• MIM: 190230
• UniProt ID: P10600