TGFBR1 Protein

TGFBR1

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TGFBR1

Official Full Name transforming growth factor, beta receptor 1
Background The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta,;transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine;protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple;transcript variants encoding different isoforms have been found for this gene.
Synonyms TGFBR1; transforming growth factor, beta receptor 1; transforming growth factor, beta receptor I (activin A receptor type II like kinase, 53kD); TGF-beta receptor type-1; activin A receptor type II like kinase; 53kDa; ACVRLK4; ALK 5; tbetaR-I; TGF-beta re
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Sf21 Insect Cell
    • Sf9 Insect Cell
    • Tag :
    • Fc
    • Fc Chimera
    • His
    • Flag
    • GST
    • His/GST
    • His-Avi
    • mFc-Avi
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TGFBR1-1495H Recombinant Human TGFBR1 (Active), GST-tagged Sf9 Insect Cell GST
    Human TGFBR1-1499H Recombinant Human TGFBR1, GST-tagged Sf9 Insect Cell GST
    Human TGFBR1-1543H Recombinant Human TGFBR1, Unactive, GST-tagged Sf9 Insect Cell GST
    Human TGFBR1-2346H Recombinant Human TGFBR1, Fc-His tagged Human Cell Fc/His
    Human TGFBR1-31137TH Recombinant Human TGFBR1 Sf9 Insect Cell N/A
    Human TGFBR1-31138TH Recombinant Human TGFBR1 N/A
    Human TGFBR1-39H Recombinant Human TGFBR1 (T204D), GST-tagged Sf9 Insect Cell GST
    Human TGFBR1-5523H Recombinant Human Transforming Growth Factor, Beta Receptor 1 Sf9 Insect Cell N/A
    Human TGFBR1-589H Recombinant Human TGFBR1 Protein, His-tagged E.coli His
    Human TGFBR1-695H Recombinant Human TGFBR1, Fc-tagged, Biotinylated Human Cell Fc
    Human TGFBR1-696H Recombinant Human TGFBR1, Fc-tagged Human Cell Fc
    Human TGFBR1-716H Recombinant Human TGFBR1, GST-His Sf9 Insect Cell GST
    Human TGFBR1-83H Recombinant Human TGFBR1 protein, Flag-tagged, Biotinylated Insect Cell Flag
    Human TGFBR1-8656H Recombinant Human TGFBR1, His-GST tagged Insect Cell His
    Mouse Tgfbr1-1777M Recombinant Mouse Tgfbr1 Protein, Fc-tagged Insect Cell Fc
    Mouse Tgfbr1-439M Recombinant Mouse Tgfbr1, Fc Chimera Sf21 Insect Cell Fc Chimera
    Chicken TGFBR1-5819C Recombinant Chicken TGFBR1 Mammalian Cell His
    Human TGFBR1-001HCL Recombinant Human TGFBR1 cell lysate Insect Cell N/A
    Human TGFBR1-2482HCL Recombinant Human TGFBR1 cell lysate Human Cell N/A
    Human TGFBR1-143H Recombinant Human TGFBR1 protein, His & GST-tagged Insect Cell His/GST
    Mouse Tgfbr1-175M Recombinant Mouse Tgfbr1(Leu30-Glu125) Protein, C-Fc-tagged HEK293 Fc
    Human TGFBR1-4379H Recombinant Human TGFBR1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human TGFBR1-697H Recombinant Human TGFBR1 protein, His-Avi-tagged HEK293 His-Avi
    Human TGFBR1-698H Recombinant Human TGFBR1 Protein, mFc-Avi-tagged HEK293 mFc-Avi
    Human TGFBR1-701H Recombinant Human TGFBR1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Mouse Tgfbr1-6392M Recombinant Mouse Tgfbr1 Protein, Myc/DDK-tagged HEK293T Myc/DDK

    TGFBR1 involved in several pathways and played different roles in them. We selected most pathways TGFBR1 participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TGFBR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway SRF; FGF1A; PTPRR; NFATC3; PPM1NB; CACNB1; MAPK4; MAP3K2; ARRB1; PRKACBA
    Cytokine-cytokine receptor interaction CCL19; CX3CR1; CXCL14; TGFB2; IFNA13; Il23a; Il12b; IL8L1; EDA; IL10RA; CXCL12A
    FoxO signaling pathway NLK; G6PCA.1; INSRA; SMAD3A; PIK3CB; SETD7; MAPK8; MAPK1; IGF1R; PIK3R3B
    Endocytosis CAV3; ADRB2B; LDLRA; F2R; CYTH2; TGFBR1A; ACAP2; CBLB; EHD2; CHMP2BA
    TGF-beta signaling pathway TGFBR1A; SMAD7; BMPR1BB; ACVR1; TGFBR1B; NBL1; SMAD4; ID2A; BMP4; ROCK1
    Osteoclast differentiation MAPK8; MAPK3; MAPK12; MAP2K1; IKBKB; PIK3R1; LILRA4; LILRA1; LILRB3; TGFBR2
    Hippo signaling pathway FZD9; WNT9B; PPP1CA; BMP6; APC2; GDF5; AFP; MPP5; WNT2B; PARD6A
    Adherens junction FYNA; ACTB2; AASS; TGFBR1A; ERBB2; NLK1; ACTG1; IGF1R; IGF1RA; ACTN3
    Chagas disease (American trypanosomiasis) MYD88; SERPINE1; CD3G; MAPK9; FADD; TGFB1; CXCL8; MAPK12; GNAI2; TLR9
    Hepatitis B FOS; HSPG2; NFATC3; CASP9; HRAS; EP300; MAP2K2; KRAS; MAP2K1; PIK3R3
    HTLV-I infection CDC26; WNT2; ATF3; FZD10; STAT5B; XBP1; EP300; Il2; HLA-DRB5; DLG1
    Pathways in cancer PRKACA; FGF5; STAT1; MAP2K2; ITGB1; RAF1; GNG4; F2R; PIK3CA; STAT5B
    Colorectal cancer CASP9; APC; TRP53; BAD; CCND1; DCC; MAPK3; MAPK9; MLH1; RALGDS
    Pancreatic cancer PIK3CA; MAPK8; VEGFA; PIK3R3; SMAD2; BRAF; TGFBR2; TGFB2; ERBB2; TRP53
    Chronic myeloid leukemia TGFBR1; BCL2L1; AKT2; BAD; CRK; AKT1; STAT5B; RB1; PIK3CA; CBLB

    TGFBR1 has several biochemical functions, for example, ATP binding, I-SMAD binding, SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TGFBR1 itself. We selected most functions TGFBR1 had, and list some proteins which have the same functions with TGFBR1. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding UBE2H; TIMM44; PRKCBA; PAPSS2B; VMHCL; STK32A; HIPK1; CSNK1G2B; PKMYT1; UBA3
    I-SMAD binding TGFB1I1; TGFBR1; CTNNB1; SMURF1; SMAD7; SMAD2; AXIN2; SMAD6; SMAD1; AXIN1
    SMAD binding SMURF2; HIPK2; TGFBR1; TGFBR2; SKI; TCF12; TOB1; MEF2A; HMGA2; SKILB
    contributes_to growth factor binding IL6ST; ERBB2; ACVR1B; TGFBR1
    metal ion binding PDLIM5B; GLI2A; DNAJA2L; ZNF829; BTR16; ACVR1B; CYP2AA8; DEM1; SMYD2; ZFP536
    protein binding TXN; BRD9; TRAF2; EHD4; DUSP13; YY1; DRAXIN; DYSFIP1; RAN; COMMD2
    protein kinase activity PAN3; AURKC; SRPK1A; CDK11A; MKNK2A; NPRL2; DCKL1B; NLK; RPS6KA3B; LIMK1
    protein serine/threonine kinase activity WNK2; NEK9; SNRK; NIM1; CAMK2D2; TRIOA; AURKA; GM711; AAK1; HIPK1
    receptor signaling protein activity FCAR; FCGR1A; ADRB1; ADCYAP1; Siglece; RGS12; IL1RL1; ARF1; RGS14; KLK1B3
    receptor signaling protein serine/threonine kinase activity PAK2B; ACVR2B; NEK4; ALPK2; ACVRL1; TGFB2; ACVR1BA; OXSR1B; BMPR1A; AMHR2
    transforming growth factor beta binding LTBP1; ENG; TGFBR2; HYAL2; TGFBR3; TGFBR1; THBS1; ACVRL1; LTBP4; ACVR1
    contributes_to transforming growth factor beta binding ENG; TGFBR3; TGFBR2; TGFBR1
    transforming growth factor beta receptor activity, type I TGFBR1; BMPR1B; ACVR1
    transforming growth factor beta-activated receptor activity TGFBR3; TGFBR1; BMPR2A; ACVRL1; ENG; LTBP1; BMPR2B; TGFBR2
    contributes_to transforming growth factor beta-activated receptor activity TGFBR1
    type II transforming growth factor beta receptor binding TGFB1; TGFB2; TGFBR1; ENG; BAMBI; TGFB3; TGFBR3; TGFB1A

    TGFBR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TGFBR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TGFBR1.

    q99ib8-pro_0000045599; TGFB3; FKBP1A; YWHAZ; TGFB1; Rnf5

    TGF

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