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Official Full Name transforming growth factor, beta receptor 1
Background The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta,;transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine;protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple;transcript variants encoding different isoforms have been found for this gene.
Synonyms TGFBR1; transforming growth factor, beta receptor 1; transforming growth factor, beta receptor I (activin A receptor type II like kinase, 53kD); TGF-beta receptor type-1; activin A receptor type II like kinase; 53kDa; ACVRLK4; ALK 5; tbetaR-I; TGF-beta re
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Sf21 Insect Cell
    • Sf9 Insect Cell
    • Tag :
    • Fc
    • Fc Chimera
    • His
    • Flag
    • GST
    • His-Avi
    • mFc-Avi
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Tgfbr1-175M Recombinant Mouse Tgfbr1(Leu30-Glu125) Protein, C-Fc-tagged HEK293 Fc
    Human TGFBR1-001HCL Recombinant Human TGFBR1 cell lysate Insect Cell N/A
    Human TGFBR1-1495H Recombinant Human TGFBR1 (Active), GST-tagged Sf9 Insect Cell GST
    Human TGFBR1-1499H Recombinant Human TGFBR1, GST-tagged Sf9 Insect Cell GST
    Human TGFBR1-1543H Recombinant Human TGFBR1, Unactive, GST-tagged Sf9 Insect Cell GST
    Human TGFBR1-2346H Recombinant Human TGFBR1, Fc-His tagged Human Cell Fc/His
    Human TGFBR1-2482HCL Recombinant Human TGFBR1 cell lysate Human Cell N/A
    Human TGFBR1-31137TH Recombinant Human TGFBR1 Sf9 Insect Cell N/A
    Human TGFBR1-31138TH Recombinant Human TGFBR1 N/A
    Human TGFBR1-39H Recombinant Human TGFBR1 (T204D), GST-tagged Sf9 Insect Cell GST
    Human TGFBR1-4379H Recombinant Human TGFBR1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human TGFBR1-5523H Recombinant Human Transforming Growth Factor, Beta Receptor 1 Sf9 Insect Cell N/A
    Human TGFBR1-589H Recombinant Human TGFBR1 Protein, His-tagged E.coli His
    Human TGFBR1-695H Recombinant Human TGFBR1, Fc-tagged, Biotinylated Human Cell Fc
    Human TGFBR1-696H Recombinant Human TGFBR1, Fc-tagged Human Cell Fc
    Human TGFBR1-697H Recombinant Human TGFBR1 protein, His-Avi-tagged HEK293 His-Avi
    Human TGFBR1-698H Recombinant Human TGFBR1 Protein, mFc-Avi-tagged HEK293 mFc-Avi
    Human TGFBR1-701H Recombinant Human TGFBR1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human TGFBR1-716H Recombinant Human TGFBR1, GST-His Sf9 Insect Cell GST
    Human TGFBR1-83H Recombinant Human TGFBR1 protein, Flag-tagged, Biotinylated Insect Cell Flag
    Human TGFBR1-8656H Recombinant Human TGFBR1, His-GST tagged Insect Cell His
    Mouse Tgfbr1-1777M Recombinant Mouse Tgfbr1 Protein, Fc-tagged Insect Cell Fc
    Mouse Tgfbr1-439M Recombinant Mouse Tgfbr1, Fc Chimera Sf21 Insect Cell Fc Chimera
    Mouse Tgfbr1-6392M Recombinant Mouse Tgfbr1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Chicken TGFBR1-5819C Recombinant Chicken TGFBR1 Mammalian Cell His

    TGFBR1 involved in several pathways and played different roles in them. We selected most pathways TGFBR1 participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TGFBR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway PPM1AA; MAPK10; FGF6; TP53; PTPN7; IKBKG; KCNA3; RAC2; CACNB1; ARRB2
    Cytokine-cytokine receptor interaction CCL25B; IL-8; CXCR3.1; PDGFRB; IFNA7; XCL1; CXCL13; CCR6A; CCL19; IFNB1
    FoxO signaling pathway NRAS; IRS4; GADD45G; MAP2K2A; PTENA; TGFBR1A; TGFB2; MAPK9; IRS2; SMAD4
    Endocytosis WASH1; RNF41; CHMP7; IGF1R; RAB5AB; IQSEC1; CDC42L; ERBB3; SRC; AP2M1B
    TGF-beta signaling pathway ID2B; LTBP1; NOG2; TGFBR1; BMPR1BA; TGIF2; CUL1A; INHBA; BMP7; LFT2
    Osteoclast differentiation FCGR4; TGFB2; CALCR; MAP3K7; MAPK13; FCGR3A; SIRPA; LILRB1; NOX1; LCP2
    Hippo signaling pathway TGFBR2; SMAD4; WNT3A; BMPR1A; BIRC2; WNT5B; Fzd4; YWHAZ; WNT8A; TEAD1
    Adherens junction ERBB2; SMAD3; TGFBR1; PTPN1; ACTN3B; AASS; CREBBP; EGFR; CSNK2A2A; PVRL1
    Chagas disease (American trypanosomiasis) MAP2K4; IKBKG; PIK3R3; PIK3R1; IKBKB; PIK3CA; AKT2; NFKB1; CCL2; CASP8
    HTLV-I infection ANAPC7; SLC2A1; NFATC1; POLE3; Fzd4; H2-AB1; HLA-DQA2; HLA-B; SLC25A6; TGFB3
    Pathways in cancer PPARD; STAT5A; MAPK9; GNG8; RUNX1; BCR; WNT6; NTRK1; CDH1; CCNA1
    Colorectal cancer TCF7L2; PIK3R3; TGFB2; PIK3CG; TGFB3; LEF1; AKT1; BIRC5; PIK3R1; RHOA
    Pancreatic cancer VEGFA; TGFBR1; PLD1; ARAF; RAC3; PIK3CB; MAPK1; BAD; STAT1; TGFBR2
    Chronic myeloid leukemia MAPK3; BRAF; BCL2L1; CBLC; RUNX1; IKBKB; SMAD3; MAPK1; CRK; SMAD4

    TGFBR1 has several biochemical functions, for example, ATP binding, I-SMAD binding, SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TGFBR1 itself. We selected most functions TGFBR1 had, and list some proteins which have the same functions with TGFBR1. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to growth factor binding ERBB2; TGFBR1; ACVR1B; IL6ST
    metal ion binding RPS6KAL; ZNF395A; ARAF; CNOT7; FEZF2; CYP2K16; HDHD1A; OTUD7A; ARG2; ZNF143B
    protein binding FAAH; ZFP57; HSP90AA1; DRAXIN; LDHB; PRKAR1A; TTPA; ZNF239; PTK7; FAM96B
    protein kinase activity TAOK1; NRBP1; CAMK2B1; CDK14; SRC; TGFBR1; EPHB4A; MMD; TEX14; CDK8
    protein serine/threonine kinase activity EIF2AK3; PKN1B; TTK; CSNK2A1; MAP4K2; BMPR1B; CAMK2D1; BMPR1A; PRKCBB; MAP2K2
    receptor signaling protein activity TIAM2; RAF1B; IL1RL1; CD19; PLCG1; TRAIP; PDCL; KLK1B3; RGS14A; KLK1B4
    receptor signaling protein serine/threonine kinase activity ACVR1B; TGFB2; TGFBR1B; OXSR1B; ACVR1; ACVR1BA; OXSR1A; BMPR1BB; TGFBR2; SLKA
    transforming growth factor beta binding TGFBR3; ITGAV; TGFBR1; ACVR1; HYAL2; TGFB3; LTBP1; LTBP4; VASN; ACVRL1
    contributes_to transforming growth factor beta binding TGFBR1; TGFBR2; ENG; TGFBR3
    transforming growth factor beta receptor activity, type I TGFBR1; BMPR1B; ACVR1
    transforming growth factor beta-activated receptor activity TGFBR1; BMPR2B; ENG; ACVRL1; LTBP1; BMPR2A; TGFBR3; TGFBR2
    contributes_to transforming growth factor beta-activated receptor activity TGFBR1
    type II transforming growth factor beta receptor binding TGFB1; TGFBR1; BAMBI; TGFB3; ENG; TGFB2; TGFBR3; TGFB1A

    TGFBR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TGFBR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TGFBR1.

    q99ib8-pro_0000045599; TGFB3; FKBP1A; YWHAZ; TGFB1; Rnf5


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