TGFBR1

  • Official Full Name

    transforming growth factor, beta receptor 1

  • Overview

    The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta,;transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine;protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple;transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    TGFBR1; transforming growth factor, beta receptor 1; transforming growth factor, beta receptor I (activin A receptor type II like kinase, 53kD); TGF-beta receptor type-1; activin A receptor type II like kinase; 53kDa; ACVRLK4; ALK 5; tbetaR-I; TGF-beta re;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Bos taurus (Bovine)
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Human
  • Mouse
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Sf21
  • Sf21 Insect Cell
  • Sf9 Insect Cell
  • C
  • hFc
  • hIgG
  • His
  • Fc
  • Fc Chimera
  • Flag
  • GST
  • Avi
  • mFc
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TGFBR1-1495H Active Recombinant Human TGFBR1, GST-tagged Sf9 Insect Cell GST 80 aa-end
Human TGFBR1-695H Active Recombinant Human TGFBR1, Fc-tagged, Biotinylated Human Cell Fc
Human TGFBR1-696H Active Recombinant Human TGFBR1, Fc-tagged Human Cell Fc
Human TGFBR1-242H Active Recombinant Human TGFBR1(T204D)(200-end) Mutation Protein, N-GST-tagged Sf21 GST 200–end
Human TGFBR1-31137TH Recombinant Human TGFBR1 Sf9 Insect Cell N/A 424 amino acids
Human TGFBR1-2346H Active Recombinant Human TGFBR1 protein, His&hFc-tagged HEK293 His&hFc Met1-Glu125
Human TGFBR1-1543H Recombinant Human TGFBR1, Unactive, GST-tagged Sf9 Insect Cell GST 80 aa-end
Human TGFBR1-39H Recombinant Human TGFBR1 (T204D), GST-tagged Sf9 Insect Cell GST
Human TGFBR1-31138TH Recombinant Human TGFBR1 N/A
Human TGFBR1-716H Recombinant Human TGFBR1, GST-His Sf9 Insect Cell GST
Human TGFBR1-83H Recombinant Human TGFBR1 protein, Flag-tagged, Biotinylated Insect Cell Flag
Human TGFBR1-5523H Recombinant Human Transforming Growth Factor, Beta Receptor 1 Sf9 Insect Cell N/A
Human TGFBR1-1499H Recombinant Human TGFBR1, GST-tagged Sf9 Insect Cell GST
Human TGFBR1-589H Recombinant Human TGFBR1 Protein, His-tagged E.coli His Glu162~Ala403
Human TGFBR1-8656H Recombinant Human TGFBR1, His-GST tagged Insect Cell His
Human TGFBR1-001HCL Recombinant Human TGFBR1 cell lysate Insect Cell N/A
Human TGFBR1-2482HCL Recombinant Human TGFBR1 cell lysate Human Cell N/A
Human TGFBR1-4379H Recombinant Human TGFBR1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TGFBR1-698H Recombinant Human TGFBR1 Protein, mFc-Avi-tagged HEK293 mFc-Avi Leu34-Glu125
Human TGFBR1-697H Recombinant Human TGFBR1 protein, His-Avi-tagged HEK293 His-Avi Leu34-Glu125
Human TGFBR1-02H Active Recombinant Human TGFBR1 Protein (27-126aa), C-hIgG-His tagged Insect Cell C-hIgG-His 27-126aa
Human TGFBR1-6434H Recombinant Human TGFBR1 Protein (Leu34-Glu125), N-His tagged E.coli N-His Leu34-Glu125
Human TGFBR1-1292H Recombinant Human TGFBR1 Protein (T200-M503), His tagged Insect Cell His T200-M503
Human TGFBR1-143H Active Recombinant Human TGFBR1 protein(Thr200-Met503), His&GST-tagged Insect Cells N-His&GST Thr200-Met503
Human TGFBR1-701H Recombinant Human TGFBR1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human TGFBR1-4633H Recombinant Human TGFBR1 protein, His&Myc-tagged E.coli N-His&C-Myc 34-126aa
Human TGFBR1-1293H Recombinant Human TGFBR1 Protein (T200-M503), Tag Free Insect Cell No tag T200-M503
Human TGFBR1-698HB Recombinant Human TGFBR1 protein, mFc-Avi-tagged, Biotinylated HEK293 mFc-Avi Leu34-Glu125
Human TGFBR1-2326H Recombinant Human TGFBR1 protein(Met1-Leu126), hFc-tagged HEK293 C-hFc Met1-Leu126
Mouse Tgfbr1-439M Active Recombinant Mouse Tgfbr1, Fc Chimera Sf21 Insect Cell Fc Chimera
Mouse Tgfbr1-1777M Active Recombinant Mouse Tgfbr1 Protein, Fc-tagged Insect Cell Fc
Mouse Tgfbr1-6392M Recombinant Mouse Tgfbr1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Tgfbr1-175M Recombinant Mouse Tgfbr1(Leu30-Glu125) Protein, C-Fc-tagged HEK293 Fc
Bos taurus (Bovine) RFL6500BF Recombinant Full Length Bovine Tgf-Beta Receptor Type-1(Tgfbr1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (30-499)
Homo sapiens (Human) RFL34739HF Recombinant Full Length Human Tgf-Beta Receptor Type-1(Tgfbr1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (34-503)
Chicken TGFBR1-5819C Recombinant Chicken TGFBR1 Mammalian Cell His
  • Background
  • Quality Guarantee
  • Case Study
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • TGFBR1 Related Signal Pathway
TGFBR1-9.jpg

Fig1. Membrane trafficking of TGFBRs. TGFBRs on the plasma membrane are rapidly turned over through clathrin- or caveolin-mediated endocytosis. (Alexandra Vander Ark, 2018)

What is TGFBR1 protein?

TGFBR1 (transforming growth factor beta receptor 1) gene is a protein coding gene which situated on the long arm of chromosome 9 at locus 9q22. TGFβR1 or transforming growth factor, beta-receptor 1 is a member of the TGFβ receptor subfamily and is a ser/thr protein kinase that forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The TGFBR1 protein is consisted of 503 amino acids and its molecular mass is approximately 56.0 kDa.

What is the function of TGFBR1 protein?

TGFBR1 is a membrane bound serine/threonine kinase receptor. Its main function is to act as a receptor for transforming members of the growth factor-β (TGF-β) superfamily, mediating the transfer of TGF-β signals from the extracellular to the intracellular. TGF-β signaling pathway plays a key role in regulating cell proliferation, differentiation, migration, apoptosis and extracellular matrix synthesis. Normal function of TGFBR1 is essential for maintaining tissue homeostasis.

TGFBR1 Related Signaling Pathway

The TGF-β signaling pathway is the most important signaling pathway. In this pathway, TGF-β ligands first bind to TGF-β type II receptors, leading to phosphorylation of type I receptors such as TGFBR1. Phosphorylated type I receptors in turn activate SMAD proteins, which enter the nucleus and regulate gene expression. This pathway interacts with many other signaling pathways (cross-talk). For example, it interacts with pathways such as WNT, Hippo, Notch, IFN, TNF, and RAS, and this interaction can affect a variety of biological processes such as cell proliferation, differentiation, and apoptosis.

TGFBR1 Related Diseases

Normal function of TGFBR1 is essential for maintaining tissue homeostasis and inhibiting tumorigenesis, but its dysfunction has been associated with a variety of diseases, including cancer, pulmonary fibrosis, and certain genetic disorders such as Loeys-Dietz syndrome and hereditary hemorrhagic telangiectasia (HHT). In addition, there are atherosclerosis, liver cirrhosis, diabetic nephropathy and so on.

Bioapplications of TGFBR1

As a potential drug target, TGFBR1 research may drive the development of new therapeutic strategies. For example, research targeting dual inhibitors of TGF-β/PD-L1 may provide new avenues for tumor treatment.

High Purity

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TGFBR1-2.jpg

Fig2. Activity Data. (TGFBR1-698H)

Case study 1: David A Monteiro, 2021

Bone is a dynamic tissue that constantly adapts to changing mechanical demands. The transforming growth factor beta (TGFβ) signaling pathway plays several important roles in maintaining skeletal homeostasis by both coupling the bone-forming and bone-resorbing activities of osteoblasts and osteoclasts and by playing a causal role in the anabolic response of bone to applied loads. However, the extent to which the TGFβ signaling pathway in osteocytes is directly regulated by fluid shear stress (FSS) is unknown.

To investigate the effects of FSS on TGFβ signaling in osteocytes, the researchers stimulated osteocytic OCY454 cells cultured within a microfluidic platform with FSS. Relative to treatment with TGFβ, FSS induced a larger increase in levels of pSmad2/3 and Serpine1 that persisted even in the presence of a TGFβ receptor type I inhibitor. The results show that FSS stimulation rapidly induces phosphorylation of multiple TGFβ family R-Smads by stimulating multimerization and concurrently activating several TGFβ and BMP type I receptors, in a manner that requires the activity of the corresponding ligand.

TGFBR1-3.jpg

Fig1. Representative images of Smad2/3 nuclear localization in control cells or following 30-minute treatments with FSS (0.1 Pa) or TGFβ (5 ng/mL).

TGFBR1-4.jpg
Fig2. Representative western analysis of Smad phosphorylation in control cells and cells pretreated (60 minutes) with vehicle or an inhibitor of a subset of TGFβ type I receptors (SB-431542, ALK4/5/7 inhibitor.

Case study 2: Seong Ji Park, 2016

Transforming growth factor-β1 (TGF-β1) promotes tumor metastasis by inducing an epithelial-to-mesenchymal transition (EMT) in cancer cells. In this study, the researchers investigated the effects of BIX02189 and XMD8-92, pharmacologic inhibitors of the MEK5 [mitogen-activated protein kinase/extracellular-signal-regulated kinase (ERK)5] signaling pathway, on the EMT and migration of cancer cells induced by TGF-β1. In human A549 lung cancer cells, TGF-β1-induced EMT, cell motility, and expression of matrix metalloproteinase-2 were completely inhibited by BIX02189, but not by XMD8-92 or small interference RNAs specific to MEK5 and ERK5. Molecular docking simulation and kinase assays revealed that BIX02189 binds directly to the ATP-binding site of the TGF-β receptor type I (TβRI) and suppresses its kinase activity. Finally, the anti-metastatic effect of BIX02189 was validated in a TβRI-derived A549 xenograft mouse model.

TGFBR1-5.jpg

Fig3. A549 cells were pretreated with BIX02189 (upper panel) or XMD8-92 (lower panel) at the indicated concentrations for 30 min and then stimulated with TGF-β1 (5 ng/ml) for 36 h in serum-free medium.

TGFBR1-6.jpg
Fig4. A549 cells were pretreated with BIX02189 (5 μM) for 30 min and then stimulated with TGF-β1 (5 ng/ml) for an additional 30 min.
TGFBR1-7.jpg

Fig1. G–CSF–PK2-STAT3 signaling circuit in neutrophils. (Hong-Lian Wang, 2022)

TGFBR1-8.jpg

Fig2. TGF-β signaling pathway. In the Smad signaling pathway, the latent TGF-β is activated by integrins and becomes active TGF-β. (Junmin Wang, 2021)

TGFBR1 involved in several pathways and played different roles in them. We selected most pathways TGFBR1 participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TGFBR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayPRKACAB;MAPK6;CACNA1C;RPS6KA2;PPP3CA;FGF10A;RAP1A;MAPK13;TGFBR2
Cytokine-cytokine receptor interactionKDR;IFNAR2;Pdgfa&Pdgfb;IFNAR1;CXCR4B;INHBC;CCL4L2;GM13304;IL6
FoxO signaling pathwayCDKN2D;PLK2B;BRAF;PRKAB1;KLF2;TGFB1;PIK3R3B;FOXO3B;PRKAG3
EndocytosisKIF5AA;PLD1;BC2;IGF1RA;GRK4;STAMBPB;CHMP2BB;AMPH;GRK7A
TGF-beta signaling pathwayID2;ACVR2B;BMP4;TGFB2;SMURF2;BMP5;SMURF1;SMAD7;PITX2
Osteoclast differentiationTGFB1;FYN;LILRA2;FOS;RELB;IFNGR2;MAPK1;GRB2;TEC
Hippo signaling pathwayAXIN1;TCF7L2;BMP5;SNAI2;PPP1CA;SMAD7;PARD6B;CRB2;WNT3
Adherens junctionERBB2;MAPK1;ACTN3;SMAD4;FARP2;SNAI1;WASF2;ACTN2;CDC42L
Chagas disease (American trypanosomiasis)CASP8;TLR2;C3;IFNG;IL-8;RELA;CD247;TLR4;CCL5
Hepatitis BTLR2;EGR2;RELA;SRC;MAP2K2;FADD;IFNA2;TBK1;PIK3CB
HTLV-I infectionICAM1;HLA-DRB1;SLC25A5;CREM;TP53INP1;HLA-DQB1;PPP3CC;IL1R2;MAP3K3
Pathways in cancerPRKACB;PIK3CD;PDGFB;PIK3R1;WNT1;PIK3R2;PDGFRA;GNA12;HSP90AB1
Colorectal cancerRALGDS;MAPK8;MSH2;TP53;RHOA;CCND1;BAX;MAPK3;RAF1
Pancreatic cancerRAD51;PIK3CG;STAT1;RAC2;MAP2K1;TP53;SMAD2;PIK3CD;PIK3CB
Chronic myeloid leukemiaBCR;PIK3CG;SHC3;PIK3R5;RB1;MDM2;RUNX1;MAP2K1;NFKB1

TGFBR1 has several biochemical functions, for example, ATP binding, I-SMAD binding, SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TGFBR1 itself. We selected most functions TGFBR1 had, and list some proteins which have the same functions with TGFBR1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingMCM3L;TWF1;MYH1E;UPF1;KTI12;PAPSS2;UBE2M;MAPKAPK2;UBE2E2
I-SMAD bindingCTNNB1;TGFBR1;TGFB1I1;AXIN1;SMAD7;SMAD1;AXIN2;SMURF1;SMAD6
SMAD bindingFOXH1;FLNA;TGFBR1;SKIB;ACVRL1;COL1A2;SKIA;ACVR1;SMURF2
contributes_to growth factor bindingIL6ST;TGFBR1;ERBB2;ACVR1B
metal ion bindingZNF317;ZFP609;POLR2A;LEPREL1;NT5M;ZNF576;FTR72;PPP6C;CYP51
protein bindingEVL;ZBTB44;SRSF10;PLAU;ZNF543;NCLN;SERBP1;SOCS4;ERLEC1
protein kinase activityPRKAG1;MAP3K12;HIPK3B;RAF1A;CAMK1GB;CDKL2;MAP2K4A;PDPK1B;CLK4B
protein serine/threonine kinase activityTNNI3K;RPS6KA4;ATM;TTBK2;KALRN;MAST2;ARAF;RPS6KA3;TGFBR1
receptor signaling protein activitycgr2b;FLRT3;RAF1A;PLCE1;TIAM2;GNAZ;NCR1;CD19;ARF1
receptor signaling protein serine/threonine kinase activitySTK24A;TGFBR2;STK26;ACVR1C;STK25B;TGFBR1;TGFBR1B;BMPR1B;ACVR2B
transforming growth factor beta bindingHYAL2;ACVR1;VASN;ACVRL1;TGFB3;TGFBR3;CD109;THBS1;LTBP4
contributes_to transforming growth factor beta bindingTGFBR2;TGFBR1;ENG;TGFBR3
transforming growth factor beta receptor activity, type ITGFBR1;BMPR1B;ACVR1
transforming growth factor beta-activated receptor activityBMPR2A;LTBP1;ACVRL1;TGFBR2;ENG;TGFBR3;TGFBR1;BMPR2B
contributes_to transforming growth factor beta-activated receptor activity
type II transforming growth factor beta receptor bindingTGFB1;TGFBR3;BAMBI;TGFB2;TGFBR1;TGFB3;ENG;TGFB1A

TGFBR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TGFBR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TGFBR1.

q99ib8-pro_0000045599; TGFB3; FKBP1A; YWHAZ; TGFB1; Rnf5

  • Q&As
  • Reviews

Q&As (6)

Ask a question
How can the information of TGFBR1 be used for the development of therapeutic strategies? 04/12/2022

In-depth study of the signaling pathways and regulatory mechanisms of TGFBR1 can provide important clues for the development of therapeutic strategies for related diseases.

Are gene polymorphisms in TGFBR1 associated with disease susceptibility? 09/11/2021

Gene polymorphisms in TGFBR1 may be associated with susceptibility to some diseases, such as heart disease and diabetes.

Is TGFBR1 associated with diseases of the skeletal system? 04/13/2021

Yes, TGFBR1 regulates the proliferation and differentiation of osteocytes in the skeletal system and has been implicated in diseases of the skeletal system.

What is the role of the TGFBR1 pathway in liver disease? 12/12/2020

The TGFBR1 pathway is involved in a variety of pathological processes in liver diseases, such as fibrosis and the occurrence of liver cancer.

What are the inhibitors of TGFBR1? 08/01/2020

Some inhibitors of TGFBR1 have been developed, such as LY2157299 and SD-208.

What is the relationship between TGFBR1 and kidney disease? 05/29/2020

TGFBR1 may play a role in regulating glomerular injury, fibrosis and renal failure in kidney disease.

Customer Reviews (3)

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Reviews
07/19/2021

    Easy to purify and high purity in production.

    04/22/2021

      The protein has strong reducibility.

      02/17/2021

        He did well in the ELISA test.

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