TGFBR3

  • Official Full Name

    transforming growth factor, beta receptor III

  • Overview

    This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
  • Synonyms

    TGFBR3; transforming growth factor, beta receptor III; transforming growth factor, beta receptor III (betaglycan, 300kDa); transforming growth factor beta receptor type 3; betaglycan; betaglycan proteoglycan; BGCAN; TGFR-3; TGF-beta receptor type 3; TGF-b;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Human Cell
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • His
  • His (Fc)
  • Avi
  • His|GST
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TGFBR3-193H Active Recombinant Human TGFBR3 Mammalian cells N/A
Human TGFBR3-698H Active Recombinant Human TGFBR3, His-tagged, Biotinylated Human Cell His
Human TGFBR3-699H Active Recombinant Human TGFBR3, His-tagged Human Cell His
Human TGFBR3-340H Recombinant Human TGFBR3, His tagged Insect Cell His
Human TGFBR3-1685H Recombinant Human Transforming Growth Factor, Beta Receptor III Mammalian cells N/A
Human TGFBR3-001HCL Recombinant Human TGFBR3 cell lysate Insect Cell N/A
Human TGFBR3-4488H Recombinant Human TGFBR3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TGFBR3-4488H-B Recombinant Human TGFBR3 Protein Pre-coupled Magnetic Beads HEK293
Mouse Tgfbr3-658M Active Recombinant Mouse Tgfbr3 Protein, His-tagged Mammalian cells His
Mouse Tgfbr3-7042M Recombinant Mouse Tgfbr3, His tagged Human Cell His
Mouse TGFBR3-1847MCL Recombinant Mouse TGFBR3 cell lysate Human Cell N/A
Mouse Tgfbr3-297M Recombinant Mouse Tgfbr3 Protein, His/GST-tagged E.coli His/GST
Mouse Tgfbr3-9163M Recombinant Mouse Tgfbr3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Tgfbr3-705M Recombinant Mouse Tgfbr3(Gly23-Thr785) Protein, C-6*His-tagged HEK293 His
Mouse Tgfbr3-9163M-B Recombinant Mouse Tgfbr3 Protein Pre-coupled Magnetic Beads HEK293
Mouse TGFBR3-0231M Recombinant Mouse TGFBR3 protein, His-tagged HEK293 His
Rat TGFBR3-6040R Recombinant Rat TGFBR3 Protein Mammalian Cell His
Rat TGFBR3-5697R Recombinant Rat TGFBR3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat TGFBR3-5697R-B Recombinant Rat TGFBR3 Protein Pre-coupled Magnetic Beads HEK293
Rat Tgfbr3-298R Recombinant Rat Tgfbr3 Protein, His-tagged E.coli His
Chicken TGFBR3-5911C Recombinant Chicken TGFBR3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TGFBR3 Related Gene Family
  • TGFBR3 Related Research Area
  • TGFBR3 Related Signal Pathway

TGFBR3 involved in several pathways and played different roles in them. We selected most pathways TGFBR3 participated on our site, such as TGF Beta Signaling Pathway, TGF-beta Receptor Signaling Pathway, TGF-beta receptor signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with TGFBR3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
TGF Beta Signaling PathwayLEFTY1;ZFP423;ZNF423;FST;NOG;RUNX3;ENG;FOXH1;TGFBR3
TGF-beta Receptor Signaling PathwayRUNX2A;FOXH1;CTCF;JUNBA;SNIP1;NFYBB;TRAP1;ACVRL1;STAMBPL1
TGF-beta receptor signalingDAB2;EIF2A;TGFBR3;STRAP

TGFBR3 has several biochemical functions, for example, PDZ domain binding, SMAD binding, activin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TGFBR3 itself. We selected most functions TGFBR3 had, and list some proteins which have the same functions with TGFBR3. You can find most of the proteins on our site.

Function Related Protein
PDZ domain bindingPTENA;CADM1;GRIA1;GNG12;CCDC88C;LIN7C;SRR;SLC9A3R1;ACVR2A
SMAD bindingSTUB1;TGFBR3;EP300;COL5A2;BMPR1B;SMURF2;RNF111;PML;SNW1
activin bindingFKBP1A;SMURF1;ACVRL1;ENG;TGFBR3;ACVR2B;SMAD7;ACVR1;FST
coreceptor activityTGFBR3;CD86;CXCR7B;CD4;CD8B;RGMB;CXCR4;CD28;ACVR2A
fibroblast growth factor bindingPTPRZ1;FIBP;GLG1B;FGFRL1;FGFR3;FIBPA;GLG1;SCN5A;RPS19
glycosaminoglycan bindingPODXL2;ENG;EPYC;HABP2;SERPINA5;TGFBR2;CCDC80;NDNF;EGFLAM
heparin bindingRPL22;FGF2;PF4V1;C6orf25;CCDC80;SERPINA10;WISP1;MSTN;LTF
protein bindingSH2D1A;SEC14L4;RBM4;KLF3;AP2B1;SLC30A2;LACTB2;PARVG;NR1H4
contributes_to protein bindingMSH6;CPSF3L;PAK1;MEF2A;TGFBR3;ACVR2A;INHA;CRY1A;TAF10
transforming growth factor beta bindingCD109;HYAL2;TGFBR2;VASN;LTBP4;TGFBR3;THBS1;TGFB3;ACVR1
contributes_to transforming growth factor beta bindingENG;TGFBR3;TGFBR2;TGFBR1
transforming growth factor beta receptor activity, type III
transforming growth factor beta receptor bindingINHBAB;GDF6;FKBP1A;GDF11;MSTNB;LRG1;USP15;MSTN;TGFB2
transforming growth factor beta-activated receptor activityTGFBR3;ACVRL1;LTBP1;TGFBR1;ENG;BMPR2B;TGFBR2;BMPR2A
type II transforming growth factor beta receptor bindingTGFBR3;BAMBI;TGFB2;TGFB3;ENG;TGFB1;TGFBR1;TGFB1A

TGFBR3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TGFBR3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TGFBR3.

GIPC1; TGFB1; TGFB3; cutF

TGF
  • Q&As
  • Reviews

Q&As (5)

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What are the implications of TGFBR3 mutations in the context of hereditary connective tissue disorders? 03/05/2022

TGFBR3 mutations are associated with hereditary connective tissue disorders, impacting extracellular matrix homeostasis and contributing to conditions like Loeys-Dietz syndrome.

How does TGFBR3 influence embryonic development, and what are the consequences of its dysregulation during development? 04/26/2021

TGFBR3 plays a role in embryonic development, and dysregulation may lead to developmental abnormalities due to disrupted TGF-beta signaling.

Can you explain the role of TGFBR3 in mediating interactions between cells and extracellular matrix components? 07/15/2019

TGFBR3 facilitates cell-ECM interactions by modulating TGF-beta signaling, influencing processes like cell adhesion and migration.

How does TGFBR3 contribute to the modulation of TGF-beta signaling pathways? 05/24/2018

TGFBR3 acts as a co-receptor, enhancing the binding of TGF-beta ligands to TGF-beta receptors, and modulates downstream signaling events.

What are the functional consequences of TGFBR3 mutations in the context of cardiovascular diseases? 02/11/2018

TGFBR3 mutations are implicated in cardiovascular diseases, affecting TGF-beta-mediated processes in vascular smooth muscle cells and cardiac tissues.

Customer Reviews (3)

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Reviews
05/10/2022

    Great product !

    02/18/2020

      Seamless delivery process—ordered, received, and ready for experiments.

      08/31/2018

        Timely delivery is key, and this product arrived on schedule.

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