tgfbr3
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  • Official Full Name
  • transforming growth factor, beta receptor III
  • Background
  • This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
  • Synonyms
  • TGFBR3; transforming growth factor, beta receptor III; transforming growth factor, beta receptor III (betaglycan, 300kDa); transforming growth factor beta receptor type 3; betaglycan; betaglycan proteoglycan; BGCAN; TGFR-3; TGF-beta receptor type 3; TGF-b
Cat.#:Tgfbr3-297MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tgfbr3 Protein, His/GST-tagged
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Cat.#:Tgfbr3-298RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Tgfbr3 Protein, His-tagged
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Cat.#:TGFBR3-1685HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human Transforming Growth Factor, Beta Receptor III
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Cat.#:TGFBR3-193HTag:
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human TGFBR3
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Cat.#:TGFBR3-340HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human TGFBR3, His tagged
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Cat.#:TGFBR3-698HTag:His
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human TGFBR3, His-tagged, Biotinylated
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Cat.#:TGFBR3-699HTag:His
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human TGFBR3, His-tagged
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Cat.#:Tgfbr3-658MTag:His
Source (Host):NSO CellsSpecies:Mouse
Product nameRecombinant Mouse Tgfbr3 Protein, His-tagged
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Cat.#:Tgfbr3-7042MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Tgfbr3, His tagged
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Cat.#:TGFBR3-6040RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TGFBR3 Protein
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Cat.#:TGFBR3-5911CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TGFBR3
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Cat.#:TGFBR3-001HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human TGFBR3 cell lysate
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Cat.#:TGFBR3-1847MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse TGFBR3 cell lysate
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Involved Pathway

TGFBR3 involved in several pathways and played different roles in them. We selected most pathways TGFBR3 participated on our site, such as TGF Beta Signaling Pathway, TGF-beta Receptor Signaling Pathway, TGF-beta receptor signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with TGFBR3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
TGF Beta Signaling Pathway
NOG; ZFP423; FST; LEFTY1; ZNF423; RUNX3; ENG; FOXH1; TGFBR3
TGF-beta Receptor Signaling Pathway
DAB2; ACVRL1; STAMBPL1; COPS5; STRAP; STK11IP; CITED1; ENG; NFYBB; SKIA
TGF-beta receptor signaling
EIF2A; TGFBR3; STRAP; DAB2

Protein Function

TGFBR3 has several biochemical functions, for example, PDZ domain binding, SMAD binding, activin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TGFBR3 itself. We selected most functions TGFBR3 had, and list some proteins which have the same functions with TGFBR3. You can find most of the proteins on our site.
Function
Related Protein
Function PDZ domain binding
Related Protein KIF14; CXADR; NKD1; GNG12; DTNA; ATP2B1A; LPAR1; CADM1; GIPC1; DOCK4
Function SMAD binding
Related Protein SKOR1A; USP15; PURB; SKOR1; ACVRL1; HIPK2; YY1; CTNNB1; TGFBR3; BMPR1B
Function activin binding
Related Protein ACVRL1; ACVR2B; FST; ENG; SMURF1; SMAD7; FSTL3; ACVR1; TGFBR3; FKBP1A
Function coreceptor activity
Related Protein LRP5; RGMA; CXCR7B; RGMD; TMIGD2; RAMP3; RAMP1; CD86; ACVR2A; RAMP2
Function fibroblast growth factor binding
Related Protein RPS2; S100A13; FGFR3; SCN5A; GPC1; KLB; FGFR1A; CEP57; TGFBR3; FGFR4
Function glycosaminoglycan binding
Related Protein SERPINE2; CCDC80; EGFLAM; SERPINA5; BGN; TGFBR3; ENG; Shh; HABP2; SPOCK3
Function heparin binding
Related Protein FGF12; THBS4; PGF; APLP1; FGF10; CFH; CHRD; Epy; ZNF207; GM4980
Function protein binding
Related Protein TDRD7; RBFOX1; DDX17; EXOC3L; EPB41L1; TMEM100; PRAM1; TSR2; CAML; FHL5
Function contributes_to protein binding
Related Protein TGFBR3; INTS10; TAF10; MEF2A; MSH6; POLR2A; INHA; MSH2; MLH1; PAK1
Function transforming growth factor beta binding
Related Protein TGFBR2; CD109; VASN; TGFBR3; ACVRL1; THBS1; HYAL2; ITGAV; LTBP4; TGFB3
Function contributes_to transforming growth factor beta binding
Related Protein TGFBR2; TGFBR3; TGFBR1; ENG
Function transforming growth factor beta receptor activity, type III
Related Protein TGFBR3
Function transforming growth factor beta receptor binding
Related Protein INHBE; GDF7; MSTNA; BMP4; SMAD3; GDF6B; BMP6; BMP2B; SMAD2; INHBA
Function transforming growth factor beta-activated receptor activity
Related Protein TGFBR1; TGFBR3; BMPR2A; ENG; ACVRL1; LTBP1; BMPR2B; TGFBR2
Function type II transforming growth factor beta receptor binding
Related Protein TGFB1; TGFB3; ENG; TGFBR3; TGFB1A; BAMBI; TGFB2; TGFBR1

Interacting Protein

TGFBR3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TGFBR3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TGFBR3.
GIPC1; TGFB1; TGFB3; cutF

TGFBR3 Related Gene Family

TGF