| Official Full Name | transforming growth factor, beta receptor III |
| Background | This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. |
| Synonyms | TGFBR3; transforming growth factor, beta receptor III; transforming growth factor, beta receptor III (betaglycan, 300kDa); transforming growth factor beta receptor type 3; betaglycan; betaglycan proteoglycan; BGCAN; TGFR-3; TGF-beta receptor type 3; TGF-b |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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TGFBR3 involved in several pathways and played different roles in them. We selected most pathways TGFBR3 participated on our site, such as TGF Beta Signaling Pathway, TGF-beta Receptor Signaling Pathway, TGF-beta receptor signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with TGFBR3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| TGF Beta Signaling Pathway | FOXH1; TGFBR3; FST; RUNX3; ZFP423; ENG; ZNF423; LEFTY1; NOG |
| TGF-beta Receptor Signaling Pathway | NFYBB; RUNX2A; VDRB; CITED1; FOXH1; EID2; DAB2; STAMBPL1; COPS5; SNIP1 |
| TGF-beta receptor signaling | STRAP; DAB2; TGFBR3; EIF2A |
TGFBR3 has several biochemical functions, for example, PDZ domain binding, SMAD binding, activin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TGFBR3 itself. We selected most functions TGFBR3 had, and list some proteins which have the same functions with TGFBR3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| PDZ domain binding | ERC1; KIDINS220B; ARHGEF16; ATP2B1A; ATP2B1B; LNX1; GRIK5; LIN7B; GRIA1; ARHGAP29 |
| SMAD binding | TGFBRAP1; ACVR1; BMP2; PURA; RNF111; TGFBR3; PRDM16; SKOR1B; MEF2A; BMPR1B |
| activin binding | FSTL3; ACVR1; SMURF1; ENG; TGFBR3; FST; ACVR2B; FKBP1A; ACVRL1; SMAD7 |
| coreceptor activity | LRP5; RAMP3; LY96; CD80; PVRL1; NRP1; CD8B; CCR8; ACKR3B; HFE2 |
| fibroblast growth factor binding | FIBPB; GPC1; FGFR3; FGFRL1; RPS19; CXCL13; S100A13; FIBPA; FIBP; FGFR4 |
| glycosaminoglycan binding | PODXL2; ENG; VCAN; SPOCK3; HABP2; SERPINE2; TGFBR3; BGN; NDNF; SPOCK2 |
| heparin binding | SAA1; RSPO4; LIPG; RPL22; WISP1; FGFR1; NOV; FMOD; NRP1; ELANE |
| protein binding | PVRL3; MYOD1; CD151; ZNF224; FBXO45; FYCO1; USHBP1; SCAF8; AKAP7; TES |
| contributes_to protein binding | INTS10; MLH1; MSH2; TGFBR3; ACVR2A; POLR2A; PAK1; MEF2A; TAF10; CRY1A |
| transforming growth factor beta binding | TGFB3; TGFBR2; LTBP1; ITGAV; THBS1; ACVR1; LTBP4; HYAL2; TGFBR3; ACVRL1 |
| contributes_to transforming growth factor beta binding | TGFBR2; TGFBR3; ENG; TGFBR1 |
| transforming growth factor beta receptor activity, type III | TGFBR3 |
| transforming growth factor beta receptor binding | GDF6B; GDF10; TGFB2; GDF2; SPAW; NODAL; SMURF2; LRG1; BMP8A; BMP2 |
| transforming growth factor beta-activated receptor activity | ENG; TGFBR1; LTBP1; BMPR2B; ACVRL1; TGFBR3; TGFBR2; BMPR2A |
| type II transforming growth factor beta receptor binding | TGFB1A; TGFB2; TGFB1; TGFBR1; TGFB3; ENG; TGFBR3; BAMBI |
TGFBR3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TGFBR3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TGFBR3.
GIPC1; TGFB1; TGFB3; cutF
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