Recombinant Mouse Tgfbr3 Protein, His/GST-tagged

• Cat.No.: Tgfbr3-297M
• Product Overview: Recombinant Mouse Tgfbr3(Phe469~Pro724) fused with His/GST tag at N-terminal was expressed in E. coli.

Specification

• Source: E. coli
• Species: Mouse
• Tag: His&GST
• Form: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Molecular Mass: 60.7kDa
• Protein length: Phe469~Pro724
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: > 95%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
  If bio-activity of the protein is needed, please check active protein
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Reconstitution: Reconstitute in PBS or others

Gene Information

• Gene Name: Tgfbr3 transforming growth factor, beta receptor III [ Mus musculus ]
• Official Symbol: Tgfbr3
• Synonyms: TGFBR3; transforming growth factor, beta receptor III; transforming growth factor beta receptor type 3; TGFR-3; betaglycan; TGF-beta receptor type 3; TGF-beta receptor type III; TBRIII; AU015626; AW215636; 1110036H20Rik
• Gene ID: 21814
• mRNA Refseq: NM_011578
• Protein Refseq: NP_035708
• UniProt ID: O88393

Reviews

05/10/2022

Great product !

02/18/2020

Seamless delivery process—ordered, received, and ready for experiments.

08/31/2018

Timely delivery is key, and this product arrived on schedule.

Q&As

What are the implications of TGFBR3 mutations in the context of hereditary connective tissue disorders?

TGFBR3 mutations are associated with hereditary connective tissue disorders, impacting extracellular matrix homeostasis and contributing to conditions like Loeys-Dietz syndrome.

How does TGFBR3 influence embryonic development, and what are the consequences of its dysregulation during development?

TGFBR3 plays a role in embryonic development, and dysregulation may lead to developmental abnormalities due to disrupted TGF-beta signaling.

Can you explain the role of TGFBR3 in mediating interactions between cells and extracellular matrix components?

TGFBR3 facilitates cell-ECM interactions by modulating TGF-beta signaling, influencing processes like cell adhesion and migration.

How does TGFBR3 contribute to the modulation of TGF-beta signaling pathways?

TGFBR3 acts as a co-receptor, enhancing the binding of TGF-beta ligands to TGF-beta receptors, and modulates downstream signaling events.

What are the functional consequences of TGFBR3 mutations in the context of cardiovascular diseases?

TGFBR3 mutations are implicated in cardiovascular diseases, affecting TGF-beta-mediated processes in vascular smooth muscle cells and cardiac tissues.