Recombinant Human Transforming Growth Factor, Beta Receptor III
| Cat.No. : | TGFBR3-1685H |
| Product Overview : | Recombinant Human TGFBR3 encoding the amino terminal 781 amino acid residue extracellular domain of human TGF-β receptor type III was inserted into a suitable mammalian expression vector and expressed in a mouse myeloma cell line,NSO. |
- Specification
- Gene Information
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| Cat. No. : | TGFBR3-1685H |
| Description : | Transforming growth factor-beta (TGF-beta) signals through three highly conserved cell surface receptors, the type III TGF-beta receptor (T beta RIII), the type II TGF-beta receptor (T beta RII), and the type I TGF-beta receptor (T beta RI) to regulate diverse cellular processes including cell proliferation, differentiation, migration, and apoptosis. T beta RIII is a heparan sulfate proteoglycan with a short cytoplasmic tail that functions as a TGF-beta superfamily co-receptor, contributing to TGF-beta signaling. T-beta-RIII might provide a mechanism for the distinct effects of TGF-beta at the different stages of breast cancer. |
| Molecular Weight : | The predicted molecular weight of Recombinant Human TGF-β soluble Receptor III is Mr 84 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 100 kDa. |
| Source : | Mammalian cells |
| State Of Matter : | Lyophilized. |
| Purity : | >90% by SDS Page and analyzed by silver stain. |
| Endotoxin : | <1.0 EU/µg as determined by the LAL method. |
| Biological Activity : | The biological activity of Human TGF-β soluble Receptor III was determined by its ability to inhibit the TGF-β2 mediated response of a mouse T cell line, HT-2 (Tsang, M. et al., 1995, Cytokine 7:389). The expected ED50 is approximately 20 - 50 ng/mL to inhibit 50% of the biological response due to 0.4 ng/mL of TGF-β2. |
| Storage And Stability : | This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions. |
| Gene Name : | TGFBR3 transforming growth factor, beta receptor III [ Homo sapiens ] |
| Synonyms : | TGFBR3; transforming growth factor, beta receptor III; BGCAN; betaglycan; betaglycan proteoglycan; transforming growth factor, beta receptor III (betaglycan, 300kDa); TGF-beta receptor type III; TGFR-3 |
| Gene ID : | 7049 |
| mRNA Refseq : | NM_003243 |
| Protein Refseq : | NP_003234 |
| MIM : | 600742 |
| UniProt ID : | Q03167 |
| Chromosome Location : | 1p33-p32 |
| Function : | PDZ domain binding; SMAD binding; coreceptor activity; heparin binding; transforming growth factor beta binding; transforming growth factor beta receptor activity, type III; type II transforming growth factor beta receptor binding |
Products Types
| ◆ Recombinant Protein | ||
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| TGFBR3-4488H | Recombinant Human TGFBR3 Protein, His (Fc)-Avi-tagged | +Inquiry |
| Tgfbr3-9163M | Recombinant Mouse Tgfbr3 Protein, His (Fc)-Avi-tagged | +Inquiry |
| Tgfbr3-297M | Recombinant Mouse Tgfbr3 Protein, His/GST-tagged | +Inquiry |
| Tgfbr3-298R | Recombinant Rat Tgfbr3 Protein, His-tagged | +Inquiry |
| ◆ Lysates | ||
| TGFBR3-1847MCL | Recombinant Mouse TGFBR3 cell lysate | +Inquiry |
| TGFBR3-001HCL | Recombinant Human TGFBR3 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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