TH1L
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Official Full Name
TH1-like -
Overview
Negative Elongation Factor (NELF) consists of four subunits: WHSC2 (NELF-A), COBRA-1 (NELF-B), TH1L (NELF-C/D), and NELF-E. NELF, together with DRB-sensitivity inducing factor (DSIF), inhibits RNA Polymerase II (RNAPII) elongation resulting in RNAPII prom -
Synonyms
TH1L;TH1-like (Drosophila);TH1 like (Drosophila homolog);negative elongation factor C/D;HSPC130;NELF C;NELF D;TH1;trihydrophobin 1;NELF-C/D;TH1-like protein;TH1 drosophila homolog;negative elongation factor proteins C and D;NELF-C;NELF-D
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TH1L-3212H | Recombinant Human TH1L, GST-tagged | E.coli | Human | GST | C-term-350aa | |
| TH1L-16726M | Recombinant Mouse TH1L Protein | Mammalian Cells | Mouse | His |
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| TH1L-1769HCL | Recombinant Human TH1L cell lysate | Human | Non |
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| TH1L-9174M | Recombinant Mouse TH1L Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| TH1L-9174M-B | Recombinant Mouse TH1L Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
TH1L involved in several pathways and played different roles in them. We selected most pathways TH1L participated on our site, such as Abortive elongation of HIV-1 transcript in the absence of Tat,Disease,Formation of HIV elongation complex in the absence of HIV Tat, which may be useful for your reference. Also, other proteins which involved in the same pathway with TH1L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Formation of HIV-1 elongation complex containing HIV-1 Tat | TCEB3,COBRA1,WHSC2,CDK9,SUPT4H1,CTDP1,TCEA1,ELL,RDBP,SSRP1 |
| Formation of HIV elongation complex in the absence of HIV Tat | PSTPIP2,SUPT4H1,SUPT5H,SSRP1,TCEA1,ELL,TCEB3,CTDP1,RDBP,WHSC2 |
| Abortive elongation of HIV-1 transcript in the absence of Tat | RDBP,CTDP1,COBRA1,SUPT5H,WHSC2,SUPT4H1 |
| Formation of the Early Elongation Complex | WHSC2,SUPT4H1,RDBP,CTDP1,COBRA1,SUPT5H,GM3258,NELFE |
| Disease | NMT1,IPO5,NUPL2,SFTPC,GCKR,OPN1SW,AMN,CHMP4C,KPNA5,HEY1 |
| Formation of the HIV-1 Early Elongation Complex | COBRA1,SUPT4H1,RDBP,CTDP1,WHSC2,SUPT5H |
| Formation of RNA Pol II elongation complex | CDK9,SSRP1A,NELFE,CCNT2A,SSRP1,TCEB3,COBRA1,GM3258,CCNT2B,TCEA1 |
| Gene Expression | PRMT5,ZNF189,ADARB1A,IGF2BP2,FAM36A,ZNF606,GTF3C5,TET3,ESR2B,ZNF461 |
Protein Function
TH1L has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TH1L itself. We selected most functions TH1L had, and list some proteins which have the same functions with TH1L. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ZNF167,ARHGEF38,SGTA,ANGPT1,XRN1,HIST1H2AG,HAGH,PRKACA,NTRK3,EIF3M |
Interacting Protein
TH1L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TH1L here. Most of them are supplied by our site. Hope this information will be useful for your research of TH1L.
NELFA;ARAF;CACNA1A;PRMT5;EPRS;DNAJA1;ARPC4;SERF2;GSTM4;UBE3A;MTA1;SMAD4;AAMP;ZNF638
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References
- Loo, LWM; Tiirikainen, M; et al. Integrated analysis of genome-wide copy number alterations and gene expression in microsatellite stable, CpG island methylator phenotype-negative colon cancer. GENES CHROMOSOMES & CANCER 52:450-466(2013).
- Antunes, AA; Leite, KR; et al. The Role of Prostate Specific Membrane Antigen and Pepsinogen C Tissue Expression as an Adjunctive Method to Prostate Cancer Diagnosis. JOURNAL OF UROLOGY 181:594-600(2009).
