THOC4

  • Official Full Name

    THO complex 4

  • Overview

    The protein encoded by this gene is a heat stable, nuclear protein and functions as a molecular chaperone. It is thought to regulate dimerization, DNA binding, and transcriptional activity of basic region-leucine zipper (bZIP) proteins.

  • Synonyms

    THOC4;THO complex 4;THO complex subunit 4;ALY;ALY/REF;BEF;REF;Ally of AML1 and LEF1;bZIP enhancing factor;THOC 4;THOC-4;Transcriptional coactivator;tho4;OTTHUMP00000218275;ally of AML-1 and LEF-1;bZIP-enhancing factor BEF;transcriptional coactivator Aly/REF
Cat.# Product name Source (Host) Species Tag Protein Length Price
THOC4-4704R Recombinant Rhesus monkey THOC4 Protein, His-tagged Mammalian Cells Rhesus macaque His
THOC4-1093HCL Recombinant Human THOC4 293 Cell Lysate HEK293 Human Non
THOC4-4518R Recombinant Rhesus Macaque THOC4 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
THOC4-4518R-B Recombinant Rhesus Macaque THOC4 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque

    Involved Pathway

    THOC4 involved in several pathways and played different roles in them. We selected most pathways THOC4 participated on our site, such as Cleavage of Growing Transcript in the Termination Region,Gene Expression,Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with THOC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Spliceosome THOC1,HNRNPC,HSPA8,HNRPKL,SRSF10,SNRNP27,LSM4,SF3B3,HNRPK,SNRPA1
    RNA Polymerase II Transcription SLBP,NELFE,CCNT2B,CLP1,SSRP1A,SUPT16H,U2AF2,CSTF3,LSM10,RNPS1
    Cleavage of Growing Transcript in the Termination Region SLBP,CSTF3,NUDT21,CSTF2,LSM11,CSTF1,PAPOLA,SRSF11,ZNF473,ZFP473
    Gene Expression ZNF215,ZNF234,HNRNPH1L,ZNF43,TRIM33,LSM10,ZCRB1,VDRB,SMG8,ZNF205
    RNA Polymerase II Transcription Termination LSM10,SRSF11,RNPS1,LSM11,SLBP,CSTF2,CSTF1,ZNF473,CLP1,PAPOLA
    Herpes simplex infection MHC2DAB,SRSF2B,MHC1UXA2,CDC34A,IFNA10,TNF,IFNAR1,PPP1CC,NFKBIA,SRSF7A
    Processing of Capped Intron-Containing Pre-mRNA METTL14,NUDT21,HNRNPH1L,PTBP1B,HNRNPF,CCAR1,HNRNPA0L,METTL3,SF3B4,PDCD7
    RNA transport SUMO2,TACC3,RBM8A,UPF3A,FXR2,POP5,THOC5,EIF3F,NUP153,EIF4E1B

    Protein Function

    THOC4 has several biochemical functions, for example, nucleotide binding,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by THOC4 itself. We selected most functions THOC4 had, and list some proteins which have the same functions with THOC4. You can find most of the proteins on our site.

    Function Related Protein
    nucleotide binding NUBP2,ATP8B1,SETX,ACTA1B,KITB,GDPGP1,PABPC3,CSNK2A2A,RBPMS2,CHD8
    protein binding WT1,ROPN1L,ADORA1,ETL4,NAA16,HAX1,ZFP64,MEIOB,GAK,SPRR1A
    poly(A) RNA binding RTN4,NUDT16L1,NSA2,PATL1,AATF,ZFP36L1,PRR3,CCAR1,EIF4G1,HLTF

    Interacting Protein

    THOC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with THOC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of THOC4.

    DDX39B;THOC1;NXF1;THOC5;EIF4A3

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