TINF2

  • Official Full Name

    TERF1 (TRF1)-interacting nuclear factor 2
  • Overview

    This gene encodes one of the proteins of the shelterin, or telosome, complex which protects telomeres by allowing the cell to distinguish between telomeres and regions of DNA damage. The protein encoded by this gene is a critical part of shelterin; it interacts with the three DNA-binding proteins of the shelterin complex, and it is important for assembly of the complex. Mutations in this gene cause dyskeratosis congenita (DKC), an inherited bone marrow failure syndrome. [provided by RefSeq, Mar 2010]
  • Synonyms

    TINF2;TERF1 (TRF1)-interacting nuclear factor 2;TIN2;DKCA3;TERF1-interacting nuclear factor 2;TRF1-interacting nuclear protein 2
Cat.# Product name Source (Host) Species Tag Protein Length Price
TINF2-4976Z Recombinant Zebrafish TINF2 Mammalian Cells Zebrafish His
TINF2-1060HCL Recombinant Human TINF2 293 Cell Lysate HEK293 Human Non

    Involved Pathway

    TINF2 involved in several pathways and played different roles in them. We selected most pathways TINF2 participated on our site, such as Cell Cycle,Cellular Senescence,Cellular responses to stress, which may be useful for your reference. Also, other proteins which involved in the same pathway with TINF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Meiosis SYNE1,SYCE1,MSH5,SPO11,MSH4,TERF1,TERF2IP,STAG1,DMC1,MND1
    Cell cycle PMF1,ODF2,SMAD4,HIST4H4,NEDD1,SMC1AL,ORC4,POLD3,YWHAE2,MCM9
    Cellular responses to stress MAP1LC3C,ST13,CBX6,HMGA1,CHMP4C,CBX6A,CHMP4B,EPAS1B,ATG9A,DNAJB6
    Cellular Senescence RING1,POT1,BMI1B,RBBP7,E2F3,BMI1A,CABIN1,HIST1H1E,CBX8B,H3F3B.1
    Packaging Of Telomere Ends ACD,POT1A,TERF1,TERF2,POT1
    Meiotic synapsis TERF2,DIDO1,FKBP6,SYCE1,POT1A,POT1,SYNE2,TEX12,SYCE2,SYCP1
    Chromosome Maintenance SMARCA5,TERF2IP,DKC1,CENPK,CENPI,RBBP4,POLD3,CENPQ,POT1,APITD1
    DNA Damage/Telomere Stress Induced Senescence TERF2IP,TERF2,HIST1H1E,POT1A,HMGA1-RS1,RAD50,HIST1H1B,HIST1H1C,TERF1,HTATIP

    Protein Function

    TINF2 has several biochemical functions, for example, NOT DNA binding,protein binding,telomeric DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TINF2 itself. We selected most functions TINF2 had, and list some proteins which have the same functions with TINF2. You can find most of the proteins on our site.

    Function Related Protein
    NOT DNA binding SKIL,MBD5,HIPK2,NFIB,XRCC4
    telomeric DNA binding OBFC1,XRCC5,CDAN1,POT1A,NCL,CTC1,TERT,TP53BP1,PIF1,TERF2
    protein binding INHBB,LXN,ZNF550,SF3A1,QARS,ADAM1B,SUFU,IPO4,COMP,NUDT1

    Interacting Protein

    TINF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TINF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TINF2.

    TERF1;ACD;TERF2

    Resources

    References

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