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TLE1

Official Full Name

transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
Overview

Transducin-like enhancer protein 1 is a protein that in humans is encoded by the TLE1 gene.
Synonyms

TLE1; transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila); transducin like enhancer of split 1, homolog of Drosophila E(sp1); transducin-like enhancer protein 1; enhancer of split groucho 1; ESG; ESG1; GRG1; E(Sp1) homolog; Enhancer of split groucho like protein 1; Enhancer of split groucho-like protein 1; TLE 1; TLE1_HUMAN; Transducin like enhancer of split 1 (E(sp1) homolog Drosophila); Transducin like enhancer of split 1; Transducin like enhancer of split 1 homolog of Drosophila E(sp1); Transducin like enhancer protein 1; transducin-like enhancer of split 1, homolog of Drosophila E(sp1);

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Rhesus Macaque

Source

HEK293
HEK293T
Mammalian Cell
Mammalian cells

Tag

Flag
His
His (Fc)
Avi
Myc
DDK
Myc|DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	TLE1-1051HCL	Recombinant Human TLE1 293 Cell Lysate	HEK293	N/A	Inquiry
Human	TLE1-5906H	Recombinant Human TLE1 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK	Inquiry
Human	TLE1-860HFL	Recombinant Full Length Human TLE1 Protein, C-Flag-tagged	Mammalian cells	Flag	Inquiry
Human	TLE1-22H	Recombinant Human TLE1 Protein, MYC/DDK-tagged	HEK293T	Myc/DDK	Inquiry
Human	TLE1-2201H-B	Recombinant Human TLE1 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Human	TLE1-2201H	Recombinant Human TLE1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Rhesus Macaque	TLE1-4728R	Recombinant Rhesus monkey TLE1 Protein, His-tagged	Mammalian Cell	His	Inquiry
Rhesus Macaque	TLE1-4542R	Recombinant Rhesus Macaque TLE1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Rhesus Macaque	TLE1-4542R-B	Recombinant Rhesus Macaque TLE1 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry

Involved Pathway
Protein Function
Interacting Protein
TLE1 Related Articles

TLE1 involved in several pathways and played different roles in them. We selected most pathways TLE1 participated on our site, such as Deactivation of the beta-catenin transactivating complex, Degradation of beta-catenin by the destruction complex, Delta-Notch Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TLE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Deactivation of the beta-catenin transactivating complex	PYGO1;PYGO2;SOX9B;TLE3;TLE1;SOX9A;TLE2;SOX6;SOX13
Degradation of beta-catenin by the destruction complex	TLE2;TLE1;TLE3;TLE4;CTBP1;FAM123B;TLE3B;AES;CTBP2
Delta-Notch Signaling Pathway	SAP30;JAG2;SMAD3B;TUBB3;TLE1;CNTN1;ASCL1;APPA;TCF3B
Formation of the beta-catenin:TCF transactivating complex	TLE1;PYGO2;BCL9L;TLE4;TLE3;RBBP5;PYGO1;CDC73;TLE3B
NOTCH1 Intracellular Domain Regulates Transcription	TLE4;TLE3;HEY1;TLE2;TLE1;HEY2;HEYL;TUBB3
Notch-mediated HES/HEY network	RCAN1;BGLAP;GATA6;ASCL1;HES6;MYB;YY1;MYOD1;HEY1
Presenilin action in Notch and Wnt signaling	WIF1;KREMEN2;TLE1;AES
Regulation of Wnt-mediated beta catenin signaling and target gene transcription	KRT1;CYR61;TLE1;BCL9;CBY1;MYOG;AES;T;HBP1

TLE1 has several biochemical functions, for example, RNA polymerase II transcription corepressor activity, chromatin binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TLE1 itself. We selected most functions TLE1 had, and list some proteins which have the same functions with TLE1. You can find most of the proteins on our site.

Function	Related Protein
RNA polymerase II transcription corepressor activity	CITED2;CTBP1;SOX3;TLE1;URI1;SIN3B;TBX18;N4BP2L2;RERE
chromatin binding	TADA2A;APBB1;CENPB;CBX4;MEF2A;RELB;NPM2;DHX30;EZH1
identical protein binding	CEACAM16;TPD52L1;LDHA;DCP1A;SMAD4;PCNA;RAF1;STK4;SCHIP1
protein binding	EXOC4;EHHADH;SNX10;PRKACB;DIXDC1;EHD2;FBXO28;TTC8;ERO1LB
transcription factor binding	CRY1;SRY;NKX3;EPN1;PIAS1;NFATC2;PPARGC1A;PARP1;LMO4

TLE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TLE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TLE1.

RUNX1; RUNX3; TK1; DAZAP2; HIPK2; SYT-SSX2

Endo, M; Su, L; et al. Activating transcription factor 2 in mesenchymal tumors. HUMAN PATHOLOGY 45:276-284(2014).

Valente, AL; Tull, J; et al. Specificity of TLE1 Expression in Unclassified High-grade Sarcomas for the Diagnosis of Synovial Sarcoma. APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY 21:408-413(2013).