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Official Full Name transmembrane protein 67
Background The protein encoded by this gene localizes to the primary cilium and to the plasma membrane. The gene functions in centriole migration to the apical membrane and formation of the primary cilium. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Meckel syndrome type 3 (MKS3) and Joubert syndrome type 6 (JBTS6).
Synonyms TMEM67; transmembrane protein 67; Meckel syndrome, type 3 , MKS3; Meckelin; JBTS6; MGC26979; NPHP11; meckel syndrome type 3 protein; MKS3; TNEM67
    • Species :
    • Human
    • Source :
    • E.coli
    • Tag :
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TMEM67-3297H Recombinant Human TMEM67, His-tagged E.coli His

    tmem67 involved in several pathways and played different roles in them. We selected most pathways tmem67 participated on our site, such as Anchoring of the basal body to the plasma membrane, Assembly of the primary cilium, Organelle biogenesis and maintenance, which may be useful for your reference. Also, other proteins which involved in the same pathway with tmem67 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Anchoring of the basal body to the plasma membrane TUBG1; CKAP5; CEP70; SDCCAG8; CLASP1; CCDC123; CLASP1A; CEP290; SSNA1; CEP97
    Assembly of the primary cilium CDK5RAP2; KIF3B; CCDC123; CCT4; TTC30A; TRIP11; IFT88; BBS5; IFT80; IFT43
    Organelle biogenesis and maintenance MRPL41; KIF3CB; CCDC123; BBS7; LZTFL1; ATAT1; IFT122; MKKS; MRPL54; EXOC3

    tmem67 has several biochemical functions, for example, filamin binding, protein binding, unfolded protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by tmem67 itself. We selected most functions tmem67 had, and list some proteins which have the same functions with tmem67. You can find most of the proteins on our site.

    Function Related Protein
    filamin binding HSPB7; PDLIM2; TMEM67; FAM101B; NEBL; MICALL2; FAM101A; FBLIM1; ZNF664-FAM101A
    protein binding SLC7A11; LGALS8; DOK1; TSSK4; HNRNPC; AKAP17A; NPM1; FGFR1; CD209; CACNA1SB
    unfolded protein binding CCT8; CLPXA; PFDN2; APCS; CALR3; CCT5; TTC1; CHAF1A; DNAJA4; DNAJB6

    tmem67 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with tmem67 here. Most of them are supplied by our site. Hope this information will be useful for your research of tmem67.

    Granato, A; Giantin, M; et al. DNA and RNA isolation from canine oncologic formalin-fixed, paraffin-embedded tissues for downstream "-omic" analyses possible or not?. JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION 26:117-124(2014).
    Ao, M; Sarathy, J; et al. Chenodeoxycholic acid stimulates Cl- secretion via cAMP signaling and increases cystic fibrosis transmembrane conductance regulator phosphorylation in T84 cells. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 305:C447-C456(2013).

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