Active Recombinant Mouse Tnfrsf11a, Fc-tagged

• Cat.No.: Tnfrsf11a-472M
• Product Overview: Mouse RANK (aa 31-214) is fused at the C-terminus to the Fc portion of human IgG1.

Specification

• Species: Mouse
• Source: HEK293
• Tag: Fc
• Protein Length: 31-214 a.a.
• Description: RANK (TRANCE-R; CD265) is the receptor for RANKL/TRANCE/OPGL. It is essential for RANKL-mediated osteoclastogenesis and is involved in the regulation of interactions between T cells and dendritic cells.
• Form: Lyophilized. Contains PBS.
• Bio-activity: Inhibits mouse and human RANKL biological functions.
• Molecular Mass: ~55kDa (SDS-PAGE)
• Purity: ≥95% (SDS-PAGE)
• Stability: Stable for at least 6 months after receipt when stored at -20°C.
• Storage: Short Term Storage: +4°C; Long Term Storage: -20°C. After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. PBS containing at least 0.1% BSA should be used for further dilutions.
• Concentration: 1mg/ml after reconstitution.

Gene Information

• Gene Name: Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a [ Mus musculus ]
• Official Symbol: Tnfrsf11a
• Synonyms: TNFRSF11A; tumor necrosis factor receptor superfamily, member 11a; tumor necrosis factor receptor superfamily member 11A; receptor activator of NF-KB; receptor activator of NF-kappaB; osteoclast differentiation factor receptor; OFE; ODFR; Rank; Ly109; mRANK; TRANCE-R
• Gene ID: 21934
• mRNA Refseq: NM_009399
• Protein Refseq: NP_033425
• Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Osteoclast, organism-specific biosystem; Osteoclast differentiation, organism-specific biosystem; Osteoclast differentiation, conserved biosystem; Rheumatoid arthritis, organism-specific biosystem; Rheumatoid arthritis, conserved biosystem
• Function: binding; cytokine binding; metal ion binding; protein binding; receptor activity; transmembrane signaling receptor activity; tumor necrosis factor-activated receptor activity