Recombinant Human TNFSF14, FLAG-tagged

Cat.No. : TNFSF14-392H
Product Overview : Human LIGHT (aa 89-240) is fused at the N-terminus to a FLAG-tag.
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Description : LIGHT (HVEML; CD258) is a cytokine that binds to TNFRSF3/LTBR. It activates NF-kappa;B, stimulates the proliferation of T cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.
Source : CHO Cells
Species : Human
Tag : FLAG
Form : Lyophilized. Contains PBS.
Molecular Mass : ~25kDa (SDS-PAGE)
Purity : ≥95% (SDS-PAGE)
Stability : Stable for at least 6 months after receipt when stored at -20°C.
Storage : Short Term Storage: +4°C; Long Term Storage: -20°C. After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. PBS containing at least 0.1% BSA should be used for further dilutions.
Concentration : 0.1mg/ml after reconstitution.
Protein length : 89-240
Gene Name : TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 [ Homo sapiens ]
Official Symbol : TNFSF14
Synonyms : TNFSF14; tumor necrosis factor (ligand) superfamily, member 14; tumor necrosis factor ligand superfamily member 14; CD258; HVEM L; LIGHT; LTg; delta transmembrane LIGHT; herpesvirus entry mediator A; herpesvirus entry mediator ligand; herpesvirus entry mediator-ligand; herpes virus entry mediator ligand; ligand for herpesvirus entry mediator; tumor necrosis factor receptor-like 2; tumor necrosis factor superfamily member LIGHT; TR2; HVEML;
Gene ID : 8740
mRNA Refseq : NM_003807
Protein Refseq : NP_003798
MIM : 604520
UniProt ID : O43557
Chromosome Location : 19p13.3
Pathway : Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Herpes simplex infection, organism-specific biosystem; Herpes simplex infection, conserved biosystem;
Function : cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytokine activity; protein binding; receptor binding; tumor necrosis factor receptor binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Customer Reviews (3)

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Reviews
07/28/2020

    The extended longevity of results gave us the confidence to delve deeper into complex biological processes.

    08/01/2018

      It was reassuring to know that the product's effects persisted, allowing for thorough and comprehensive research.

      06/19/2016

        The ability to obtain enduring results positively influenced the depth of our investigations.

        Q&As (7)

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        What are the primary changes induced by TNFSF14 in the tumor microenvironment? 05/19/2022

        TNFSF14, when delivered to or expressed within tumors, causes significant changes primarily through vascular normalization and generation of tertiary lymphoid structures.

        What challenges remain in utilizing TNFSF14 for cancer immunotherapy? 07/02/2021

        While investigators have used multiple vectors to deliver TNFSF14 to tumor tissues, there are still improvements needed, and components within the human tumor microenvironment may impede translational efforts.

        What does TNFSF14 stand for? 02/05/2021

        TNFSF14 stands for Tumor Necrosis Factor Superfamily Member 14.

        How can TNFSF14 synergize with other immunotherapy modalities? 02/22/2020

        TNFSF14's changes in the tumor microenvironment can synergize with methods inducing anti-tumor immune responses, such as checkpoint inhibitors and tumor vaccines, improving immunotherapeutic strategies against cancer.

        In what context has TNFSF14 been utilized to combat cancer? 02/06/2018

        TNFSF14 has been used in multiple tumor models, where it can be combined with other immunotherapy modalities to clear established solid tumors and treat metastatic events.

        How long has TNFSF14 been in pre-clinical development? 06/11/2017

        TNFSF14 has been in pre-clinical development for over a decade.

        What is the primary promise of TNFSF14 in the field of cancer immunotherapy? 08/15/2016

        TNFSF14 shows promise in enhancing treatment approaches in cancer immunotherapy.

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