TP63
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Official Full Name
tumor protein p63
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Overview
This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined. [provided by RefSeq, Jul 2008] -
Synonyms
TP63; tumor protein p63; AIS; KET; LMS; NBP; RHS; p40; p51; p63; EEC3; OFC8; p73H; p73L; SHFM4; TP53L; TP73L; p53CP; TP53CP; B(p51A); B(p51B); tumor protein 63; CUSP; transformation-related protein 63; tumor protein p53-competing protein; amplified in squamous cell carcinoma; chronic ulcerative stomatitis protein; keratinocyte transcription factor KET; tumor protein p63 deltaN isoform delta;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Rat
- Zebrafish
- E.coli
- HEK293
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Sf9 Insect Cell
- Flag
- GST
- His
- Fc
- Avi
- Myc
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
TP63 involved in several pathways and played different roles in them. We selected most pathways TP63 participated on our site, such as MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with TP63 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MicroRNAs in cancer | ABCB1A;IRS2;ST14;Casp3;RPS6KA5;FSCN1;PLAU;PLCG1;NFKB1 |
TP63 has several biochemical functions, for example, DNA binding, WW domain binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TP63 itself. We selected most functions TP63 had, and list some proteins which have the same functions with TP63. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | ZNF572;TBX5;HIST1H4B;HIST1H3D;RCAN1;FOXC1B;HIST1H3H;HOXA13;AKNA |
| WW domain binding | WBP1;TRAF4;TCEAL3;NDFIP2;WBP11;TMEM128;SCNN1G;DAZAP2;CDC25C |
| chromatin binding | EZH1;HMGB3;HMGB3B;CDC45;KDM6B;SMC3;CEBPB;FLI1;CDCA5 |
| damaged DNA binding | NEIL2;RAD23AB;RPS3;FEN1;TP73;TRP53;EP300;RPA3;OGG1 |
| double-stranded DNA binding | AFF3;HNRPDL;USF1;APTX;NTHL1;FBXO18;TRP63;TP53;ZNF638 |
| identical protein binding | TRIM5;ALDOA;VAMP2;DYNLT1F;S100A2;DIAP1;ETNPPL;SID4;SCHIP1 |
| metal ion binding | ZBTB11;TSHZ3;TRIM3B;MB;NKD2B;NR2F5;PRPSAP2;CYP2AA4;ZNF221 |
| p53 binding | SMARCB1;TP63;AAAS;TAF3;TRIM29;PLK3;BLM;RCHY1;ZNF385B |
| protein binding | KCNQ4;CCNK;FAF2;UGP2;CLPB;C11orf65;CHID1;LBR;TRAF7 |
| sequence-specific DNA binding | VSX1;DMBX1B;FOXN2B;HOXA10B;E2F1;USF1;MYOG;ZNF323;NR2E1 |
| transcription factor activity, sequence-specific DNA binding | HMGB2;ETV5;BCL6;IRF3;E2F1;ZNF302;SIM1;ZNF480;TCF7L2 |
| transcription factor activity, transcription factor binding | CRY2;TRP63;ASCL1;PER2;ASCL1A;LDB2B;LDB1A;HIF1A;MTA2 |
| transcription regulatory region DNA binding | GLI1;HNF1A;YAP1;NR1H3;HOXA13;SOX17;ZNF821;WNT5A;SALL3B |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | MYB;PHOX2B;NFATC3;SP1;EPAS1;TXK;EBF1;MYOG;TCF12 |
TP63 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TP63 here. Most of them are supplied by our site. Hope this information will be useful for your research of TP63.
TP53; SMAD2; PPP1R13B; NIPSNAP3A; SATB2; SYNCRIP; FUS; YAP1; HNRNPK
Research Area
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