TRPC4

  • Official Full Name

    transient receptor potential cation channel, subfamily C, member 4
  • Overview

    This gene encodes a member of the canonical subfamily of transient receptor potential cation channels. The encoded;protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine;kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter;release and cell proliferation. Single nucleotide polymorphisms in this gene may be associated with generalized;epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been;observed for this gene.
  • Synonyms

    Trpc4;transient receptor potential cation channel, subfamily C, member 4;Trp4;Trrp4;HTRP4;Trp-related protein 4;hTrp-4;CCE1;capacitative calcium entry channel 1;transient receptor potential channel 4;transient receptor potential protein 4;short transient receptor potential channel 4;MGC119570;MGC119571;MGC119572;MGC119573;OTTHUMP00000018272;OTTHUMP00000018273;OTTHUMP00000018274;OTTHUMP00000018275;OTTHUMP00000018277
Cat.# Product name Source (Host) Species Tag Protein Length Price
TRPC4-744HCL Recombinant Human TRPC4 293 Cell Lysate HEK293 Human Non
TRPC4-1160HFL Recombinant Human TRPC4 protein, His&Flag-tagged HEK293 Human Flag&His 1-893 aa

    Involved Pathway

    TRPC4 involved in several pathways and played different roles in them. We selected most pathways TRPC4 participated on our site, such as Axon guidance,Developmental Biology,Ion channel transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRPC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Stimuli-sensing channels BEST3,CLCN4-2,CLCN1,MCOLN2,WNK2,TRPC5A,ANO5B,TRPC4A,ANO1,TRPM4C
    Netrin-1 signaling NTN1B,UNC5D,TRPC5,RNF8,EZRA,PITPNA,NTN1A,SIAH2,HFE2,RGMB
    Transmembrane transport of small molecules CLCN1,SLC7A6,ASPH,SLC2A8,PDZD11,SLC8A2A,SLCO3A1,ADD3,SLC9B2,SLC39A3
    Developmental Biology DPYSL3,POU5F3,PAK4,RGMB,SPRED2,AP2A1,CTNNA2,CD24,HFE2,SPTA1
    Ion channel transport BEST4,CLCN6,CLCN2,ATP1A1A.2,CLCN7,FXYD6-FXYD2,CUTC,FXYD7,ANO1,TRPM1B
    Axon guidance FES,PTPRA,RHOD,EFNB1,RHOA,CSF2,FRS3,NTN1A,NRP2,CDC42
    Role of second messengers in netrin-1 signaling TRPC5,PITPNA
    TRP channels MCOLN3,TRPC5,TRPC4APA,TRPM4A,TRPC4APB,TRPC4AP,TRPA1A,TRPM1A,TRPC4A,TRPM4C

    Protein Function

    TRPC4 has several biochemical functions, for example, beta-catenin binding,cadherin binding,inositol 1,4,5 trisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRPC4 itself. We selected most functions TRPC4 had, and list some proteins which have the same functions with TRPC4. You can find most of the proteins on our site.

    Function Related Protein
    store-operated calcium channel activity ZP3,TRPC2,TRPC5A,TRPC6,TRPC3,ORAI1B,TRPC5,TRPC2B,ORAI1,TRPC6A
    protein binding PRDM16,KIAA1524,EAF2,PADI4,GLP1R,PI4KB,ATG13,ANKFY1,SLC30A8,SHC1
    cadherin binding CTNNA1,Fert2,PROM1,CD2AP,NUMB,FXYD5,P2RX4,JUPA,NEO1,AKAP5
    beta-catenin binding PROP1,AXIN1,SLC9A3R2,GLI3,CD2AP,CBY1,CARM1,MED12,CDH5,GRIP1
    inositol 1,4,5 trisphosphate binding PLCL1,TRPC5,AKR1C1,ITPR3,TRPC7A,CYTH2,TRPC7,TRPC3,TRPC2B,TRPC6

    Interacting Protein

    TRPC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRPC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRPC4.

    ITPR2;MX1

    Resources

    References

    • Jiang, HN; Zeng, B; et al. Involvement of TRPC Channels in Lung Cancer Cell Differentiation and the Correlation Analysis in Human Non-Small Cell Lung Cancer. PLOS ONE 8:-(2013).
    • Zeng, B; Yuan, CZ; et al. TRPC Channels and Their Splice Variants are Essential for Promoting Human Ovarian Cancer Cell Proliferation and Tumorigenesis. CURRENT CANCER DRUG TARGETS 13:103-116(2013).

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