TRPC4
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Official Full Name
transient receptor potential cation channel, subfamily C, member 4 -
Overview
This gene encodes a member of the canonical subfamily of transient receptor potential cation channels. The encoded;protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine;kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter;release and cell proliferation. Single nucleotide polymorphisms in this gene may be associated with generalized;epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been;observed for this gene. -
Synonyms
Trpc4;transient receptor potential cation channel, subfamily C, member 4;Trp4;Trrp4;HTRP4;Trp-related protein 4;hTrp-4;CCE1;capacitative calcium entry channel 1;transient receptor potential channel 4;transient receptor potential protein 4;short transient receptor potential channel 4;MGC119570;MGC119571;MGC119572;MGC119573;OTTHUMP00000018272;OTTHUMP00000018273;OTTHUMP00000018274;OTTHUMP00000018275;OTTHUMP00000018277
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TRPC4-744HCL | Recombinant Human TRPC4 293 Cell Lysate | HEK293 | Human | Non |
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| TRPC4-1160HFL | Recombinant Human TRPC4 protein, His&Flag-tagged | HEK293 | Human | Flag&His | 1-893 aa |
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Involved Pathway
TRPC4 involved in several pathways and played different roles in them. We selected most pathways TRPC4 participated on our site, such as Axon guidance,Developmental Biology,Ion channel transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRPC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Developmental Biology | NRTN,NRG4,STX1B,SMAD3B,PHB,SPAG9,CNTN1,DNM2,LGI3,LGI2A |
| Stimuli-sensing channels | ANO7,TRPC4B,TSC22D3,NHEDC1,OSTM1,GSDMA2,TRPC4APA,CLCNKA,BSND,SGK2 |
| Transmembrane transport of small molecules | SLC5A11,SLC5A3A,ATP11C,CLCN1A,SLC30A1A,SLC13A4,SLC35D1A,CLIC2,SLC2A15B,ANO8 |
| TRP channels | TRPM4A,TRPC4APB,TRPC4AP,MCOLN3,MCOLN2,TRPM4C,TRPM1,TRPC4B,TRPC4APA,TRPV3 |
| Axon guidance | DLG3,ARPC4,JAK2,SEMA4C,GSK3B,RAC2,CHL1,CSF2,Sema3f,AKAP9 |
| Role of second messengers in netrin-1 signaling | TRPC5,PITPNA |
| Netrin-1 signaling | TRPC5,UNC5D,RGMA,NTN1A,NTN1B,PITPNA,RGMB,HFE2,EZRA,SIAH2 |
| Ion channel transport | FXYD6-FXYD2,WNK1,ATP2B1B,CUTC,CLIC2,BSND,TTYH2,NHEDC1,FXYD7,WWP1 |
Protein Function
TRPC4 has several biochemical functions, for example, beta-catenin binding,cadherin binding,inositol 1,4,5 trisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRPC4 itself. We selected most functions TRPC4 had, and list some proteins which have the same functions with TRPC4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| store-operated calcium channel activity | TRPC2,TRPC5,TRPC6,STIM2,ZP3,TRPC3,TRPC2B,TRPC7,ORAI3,ORAI1 |
| inositol 1,4,5 trisphosphate binding | RPH3A,TRPC6A,CYTH2,AKR1C1,TRPC5A,TRPC7,ITPR3,TRPC2,PLCL1,TRPC1 |
| protein binding | KRTAP19-5,CD24,NUP62,RHO,RALGDS,EID1,EMG1,RAB33A,MAD1L1,PODXL |
| cadherin binding | PTPRM,Fert2,CDH13,GNA13A,P2RX4,FER,CD46,AKAP5,CD2AP,MMP24 |
| beta-catenin binding | SMAD7,CTNNBIP1,KDM6B,LZIC,RORA,CDH24,SMAD3,FAM123B,APC,SLC9A3R2 |
Interacting Protein
TRPC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRPC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRPC4.
ITPR2;MX1
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References
- Jiang, HN; Zeng, B; et al. Involvement of TRPC Channels in Lung Cancer Cell Differentiation and the Correlation Analysis in Human Non-Small Cell Lung Cancer. PLOS ONE 8:-(2013).
- Zeng, B; Yuan, CZ; et al. TRPC Channels and Their Splice Variants are Essential for Promoting Human Ovarian Cancer Cell Proliferation and Tumorigenesis. CURRENT CANCER DRUG TARGETS 13:103-116(2013).
