TRPM6

  • Official Full Name

    transient receptor potential cation channel, subfamily M, member 6
  • Overview

    TRPM6 is a transient receptor potential ion channel associated with hypomagnesemia with secondary hypocalcemia.
  • Synonyms

    TRPM6;transient receptor potential cation channel, subfamily M, member 6;HOMG, HSH, hypomagnesemia, secondary hypocalcemia;transient receptor potential cation channel subfamily M member 6;CHAK2;FLJ22628;channel kinase 2;melastatin-related TRP cati
Cat.# Product name Source (Host) Species Tag Protein Length Price
TRPM6-8098Z Recombinant Zebrafish TRPM6 Mammalian Cells Zebrafish His
TRPM6-824H Recombinant Human TRPM6 Mammalian Cells Human His
TRPM6-1168HFL Recombinant Human TRPM6 protein, His&Flag-tagged HEK293 Human Flag&His 1-2017 aa
TRPM6-4248H Recombinant Human TRPM6 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
TRPM6-4248H-B Recombinant Human TRPM6 Protein Pre-coupled Magnetic Beads HEK293 Human

    Involved Pathway

    TRPM6 involved in several pathways and played different roles in them. We selected most pathways TRPM6 participated on our site, such as Ion channel transport,Mineral absorption,Stimuli-sensing channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRPM6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ion channel transport MCOLN3,CLCNK,TRPC4,TRPA1B,TRPC6A,TRPA1A,CLCN4-2,ATP13A,TRPC4APB,GABRR2A
    TRP channels TRPM4C,TRPC5,TRPC4A,TRPM1B,TRPC4APA,TRPM1,TRPM4A,TRPM1A,MCOLN2,TRPC4AP
    Stimuli-sensing channels CLCN4-2,SLC17A3,TTYH1,ANO4,TRPC4APB,MCOLN2,TTYH3,OSTM1,TRPM1B,TPCN1
    Mineral absorption MT1X,CYBRD1,SLC26A9,MT1A,SLC9A3,ATP2B1,ATP7A,ATOX1,SLC31A1,SLC5A1
    Transmembrane transport of small molecules SLC6A20A,TRPC4A,TRPC4APB,SLC41A1,SGK2,RHAG,SLC2A15B,SLC29A1A,TRPC4,ANKHB

    Protein Function

    TRPM6 has several biochemical functions, for example, ATP binding,calcium channel activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRPM6 itself. We selected most functions TRPM6 had, and list some proteins which have the same functions with TRPM6. You can find most of the proteins on our site.

    Function Related Protein
    metal ion binding CYP2AA9,ZNF446,ZNF771,NUDT11,RPS27.2,KLF2B,NPAS2,ZNF326,POLR3B,ZFP654
    protein serine/threonine kinase activity TBK1,MAP2K7,STK25,STK24,STK3,TSSK1,TLK1B,PIM1,CPNE3,SGK3
    protein binding HSPA8,PHF17,ZNF559,TPD52L3,NOTCH4,RCN1,IL15RA,ZFAND6,CCKBR,CDC40
    ATP binding GRK1B,PTK2AA,NWD1,NLRP2,TRAP1,MYO7A,UBE2C,ABCB5,TLK1B,UBE2B
    calcium channel activity CACNG2A,TRPM8,GRIN3A,CACNA1BA,TRPC6A,TRPC3,TRPV2,AKR1C1,GPM6A,CACNB2

    Interacting Protein

    TRPM6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRPM6 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRPM6.

    MYH9;MYH10;MYH14

    Resources

    References

    • Costa, A; Tejpar, S; et al. Hypomagnesaemia and targeted anti-epidermal growth factor receptor (EGFR) agents. TARGETED ONCOLOGY 6:227-233(2011).
    • Dimke, H; van der Wijst, J; et al. Effects of the EGFR Inhibitor Erlotinib on Magnesium Handling. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 21:1309-1316(2010).

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