TRPM6
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Official Full Name
transient receptor potential cation channel, subfamily M, member 6 -
Overview
TRPM6 is a transient receptor potential ion channel associated with hypomagnesemia with secondary hypocalcemia. -
Synonyms
TRPM6;transient receptor potential cation channel, subfamily M, member 6;HOMG, HSH, hypomagnesemia, secondary hypocalcemia;transient receptor potential cation channel subfamily M member 6;CHAK2;FLJ22628;channel kinase 2;melastatin-related TRP cati
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TRPM6-8098Z | Recombinant Zebrafish TRPM6 | Mammalian Cells | Zebrafish | His |
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| TRPM6-824H | Recombinant Human TRPM6 | Mammalian Cells | Human | His |
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| TRPM6-1168HFL | Recombinant Human TRPM6 protein, His&Flag-tagged | HEK293 | Human | Flag&His | 1-2017 aa |
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| TRPM6-4248H | Recombinant Human TRPM6 Protein, His (Fc)-Avi-tagged | HEK293 | Human | Avi&Fc&His |
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| TRPM6-4248H-B | Recombinant Human TRPM6 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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Involved Pathway
TRPM6 involved in several pathways and played different roles in them. We selected most pathways TRPM6 participated on our site, such as Ion channel transport,Mineral absorption,Stimuli-sensing channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRPM6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Mineral absorption | FTH1,MT1G,SLC26A9,SLC30A1,S100G,CYBRD1,TF,HMOX1,MT1X,ATP1B3 |
| Transmembrane transport of small molecules | SLC9A3.2,SLC1A2A,AQP6,SLC5A11,ATP10A,ABCF1,ANO7,CLCA1,SLCO4C1,SLC15A2 |
| TRP channels | TRPM4C,MCOLN2,TRPC4APA,TRPM1,TRPV3,TRPC5A,TRPC5,TRPM1B,MCOLN3,TRPC4APB |
| Ion channel transport | TRPC4B,TRPC4A,SLC9A10,ANO5,GLRBA,SCNN1D,CUTC,TRPC4,BEST1,ANO10 |
| Stimuli-sensing channels | ANO4,CLCN5,CLCNKA,TTYH3B,ANO5,TRPC5A,TRPM1A,TTYH3,ASIC1A,ASPH |
Protein Function
TRPM6 has several biochemical functions, for example, ATP binding,calcium channel activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRPM6 itself. We selected most functions TRPM6 had, and list some proteins which have the same functions with TRPM6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein serine/threonine kinase activity | PAK4,STK31,ERN1,STK38,DAPK1,CDK1,CAMK1DB,MAP3K9,GRK5,MARK4 |
| metal ion binding | AARS2,PMELA,FYNA,MMP1A,NRXN1,CYB5R4,SDHC,ISG20,SMYD1A,GNAQ |
| ATP binding | CDKL3,ACSS2,CDC6,HSPA13,NEK9,MTHFD1B,INSRB,KDR,CAMK2G1,PAK1 |
| protein binding | CREB5,KCNJ5,RPP25,C17orf28,ECM1,MDM2,CD163,VIP,C1QTNF2,FAM96A |
| calcium channel activity | RYR2,TRPV5,SLC24A1,CACNA1SB,TRPN1,UBXN6,TRPC4A,PDE2A,PSEN1,SLC24A4A |
Interacting Protein
TRPM6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRPM6 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRPM6.
MYH9;MYH10;MYH14
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References
- Costa, A; Tejpar, S; et al. Hypomagnesaemia and targeted anti-epidermal growth factor receptor (EGFR) agents. TARGETED ONCOLOGY 6:227-233(2011).
- Dimke, H; van der Wijst, J; et al. Effects of the EGFR Inhibitor Erlotinib on Magnesium Handling. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 21:1309-1316(2010).
