TRPV5
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Official Full Name
transient receptor potential cation channel, subfamily V, member 5
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Overview
This gene is a member of the transient receptor family and the TrpV subfamily. The calcium-selective channel encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level. [provided by RefSeq, Jul 2008] -
Synonyms
TRPV5; transient receptor potential cation channel, subfamily V, member 5; CAT2; ECAC1; OTRPC3; transient receptor potential cation channel subfamily V member 5; ECaC; calcium transporter 2; osm-9-like TRP channel 3; calcium transport protein 2; epithelial calcium channel 1;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Homo sapiens (Human)
- Human
- Mouse
- Oryctolagus cuniculus (Rabbit)
- Rat
- Rattus norvegicus (Rat)
- E. coli
- E.coli
- E.coli expression system
- HEK293
- Mammalian Cell
- His
- His (Fc)
- Avi
- Flag
- N
- Involved Pathway
- Protein Function
- Interacting Protein
TRPV5 involved in several pathways and played different roles in them. We selected most pathways TRPV5 participated on our site, such as Endocrine and other factor-regulated calcium reabsorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRPV5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Endocrine and other factor-regulated calcium reabsorption | TRPV5;PLCB4;PRKACG;KLK2;ATP1B3;KLK1B26;SLC8A1;KL;ATP1A4 |
TRPV5 has several biochemical functions, for example, calcium channel activity, calmodulin binding, ion channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRPV5 itself. We selected most functions TRPV5 had, and list some proteins which have the same functions with TRPV5. You can find most of the proteins on our site.
Function | Related Protein |
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calcium channel activity | PKD1;GRIN3A;TRPV1;ORAI1B;CACFD1;CACNG2B;TRPC1;SLC24A4A;CACNG1A |
calmodulin binding | RYR1;MKNK1;CAMK1D;DDX5;NOS1;INVS;ATP2B1;SLC9A1;CNN1 |
ion channel activity | GJD3;ASIC4;CHRNA1;CHRNB3B;KCNC1A;CACNA1DA;P2RX8;ITPR1;SCN12AB |
protein binding | PVR;EDEM1;NHP2;PPP1R15B;EDARADD;MYL7;TAOK1;SKP2;KCNH2 |
TRPV5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRPV5 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRPV5.
Wnk4; Slc9a3r2
- Q&As
- Reviews
Q&As (7)
Ask a questionTRPV5 coordinates with renal ion channels for calcium handling.
Genetic mutations in TRPV5 can affect bone density and mineral balance.
TRPV5 is key in maintaining calcium balance in the body.
Targeting TRPV5 could treat osteoporosis and prevent kidney stones.
It facilitates calcium reabsorption in the kidneys.
TRPV5 influences calcium availability for bone health.
Altered TRPV5 activity can contribute to kidney stones and renal disorders.
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