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Official Full Name tetratricopeptide repeat domain 8
Background This gene encodes a protein that has been directly linked to Bardet-Biedl syndrome. The primary features of this syndrome include retinal dystrophy, obesity, polydactyly, renal abnormalities and learning disabilities. Experimentation in non-human eukaryotes suggests that this gene is expressed in ciliated cells and that it is involved in the formation of cilia. Alternate transcriptional splice variants have been characterized.
Synonyms TTC8; tetratricopeptide repeat domain 8; tetratricopeptide repeat protein 8; BBS8; Bardet Biedl syndrome 8 protein; Bardet Biedl syndrome type 8; TPR repeat protein 8; TTC 8; OTTHUMP00000244652; OTTHUMP00000244653; OTTHUMP00000244654; OTTHUMP00000244656; OTTHUMP00000244659; Bardet-Biedl syndrome type 8; bardet-Biedl syndrome 8 protein; RP51
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TTC8-1155H Recombinant Human TTC8 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human TTC8-3477H Recombinant Human TTC8, GST-tagged E.coli GST
    Human TTC8-673HCL Recombinant Human TTC8 293 Cell Lysate HEK293 N/A
    Mouse TTC8-17578M Recombinant Mouse TTC8 Protein Mammalian Cell His
    Mouse Ttc8-6715M Recombinant Mouse Ttc8 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rhesus Macaque TTC8-5018R Recombinant Rhesus monkey TTC8 Protein, His-tagged Mammalian Cell His
    Zebrafish TTC8-3748Z Recombinant Zebrafish TTC8 Mammalian Cell His

    TTC8 involved in several pathways and played different roles in them. We selected most pathways TTC8 participated on our site, such as Assembly of the primary cilium, BBSome-mediated cargo-targeting to cilium, Cargo trafficking to the periciliary membrane, which may be useful for your reference. Also, other proteins which involved in the same pathway with TTC8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Assembly of the primary cilium TTC21B; SCLT1; RHOL; DCTN1A; WDR35; IFT27; FBF1; CDK5RAP2; MAPRE1; CKAP5
    BBSome-mediated cargo-targeting to cilium BBS2; CCT4; BBS10; LZTFL1; BBS12; RAB3IP; CCT2; MKKS; BBS7; TCP1
    Cargo trafficking to the periciliary membrane BBS7; UNC119.1; RP2; CYS1; TCP1; CCT3; LZTFL1; UNC119B; TTC8; PKD1
    Organelle biogenesis and maintenance PKD2; GFM2; GADD45GIP1; MRPL37; MRPS30; CHCHD1; MRPS22; BBS1; IFT-20; GABPA

    TTC8 has several biochemical functions, for example, RNA polymerase II repressing transcription factor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TTC8 itself. We selected most functions TTC8 had, and list some proteins which have the same functions with TTC8. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II repressing transcription factor binding PROL1; BBS2; BBS5; BBS4; STAT3; BBS10; TCERG1; CHD4; GSC; RBBP8
    protein binding MRPL9; TMEM8B; LPA; RPS14; DNM1L; TRIM35; CIR1; GNPDA2; PRDM4; PFN2

    TTC8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TTC8 here. Most of them are supplied by our site. Hope this information will be useful for your research of TTC8.

    BBS1; BBS7; BBS4; BBS2; Sstr3; BBS9; BBS5; ARL6

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