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TYW1

Official Full Name

tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)
Overview

Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW1 is the human homolog of a yeast gene essential for yW synthesis (Noma and Suzuki, 2006).
Synonyms

TYW1; tRNA-yW synthesizing protein 1 homolog (S. cerevisiae); radical S adenosyl methionine and flavodoxin domains 1 , RSAFD1; tRNA wybutosine-synthesizing protein 1 homolog; FLJ10900; MGC23001; MGC60291; tRNA yW synthesizing protein 1 homolog A (S. cerevisiae); TYW1A; YPL207W; GC23001; Radical S-adenosyl methionine and flavodoxin domain-containing protein 1; RSAFD1; tRNA-yW-synthesizing protein; TYW1_HUMAN; OTTHUMP00000160137; tRNA-yW synthesizing protein 1 homolog A; radical S-adenosyl methionine and flavodoxin domains 1;

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	TYW1-612HCL	Recombinant Human TYW1 293 Cell Lysate	HEK293	N/A	Inquiry
Mouse	TYW1-17678M	Recombinant Mouse TYW1 Protein	Mammalian Cell	His	Inquiry
Mouse	TYW1-9803M	Recombinant Mouse TYW1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	TYW1-9803M-B	Recombinant Mouse TYW1 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Zebrafish	TYW1-4615Z	Recombinant Zebrafish TYW1	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
TYW1 Related Articles

TYW1 involved in several pathways and played different roles in them. We selected most pathways TYW1 participated on our site, such as 7-(3-amino-3-carboxypropyl)-wyosine biosynthesis, Gene Expression, Synthesis of wybutosine at G37 of tRNA(Phe), which may be useful for your reference. Also, other proteins which involved in the same pathway with TYW1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
7-(3-amino-3-carboxypropyl)-wyosine biosynthesis	TYW1;TYW3
Gene Expression	ZNF184;ZNF254;ZNF596;ZNF670;LSM11;ZNF331;RRAGA;EEF2;UHRF1
Synthesis of wybutosine at G37 of tRNA(Phe)	TYW5;TYW3;TRMT5;TRMT12;TYW1;LCMT2
tRNA modification in the nucleus and cytosol	TRDMT1;METTL1;ADAT3;LAGE3;MANEA;WDR4;TP53RK;TRMT44;NSUN2
tRNA processing	TYW5;TPRKB;C2orf49;TRMT112;RPP14;THG1L;ALKBH8;TRMT12;POP4
wybutosine biosynthesis	LCMT2;TYW1;TYW3

TYW1 has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding, FMN binding, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TYW1 itself. We selected most functions TYW1 had, and list some proteins which have the same functions with TYW1. You can find most of the proteins on our site.

Function	Related Protein
4 iron, 4 sulfur cluster binding	DPYD;DPYDB;POLA1;MOCS1;ISCA1;TYW1;POLD1;ISCA2;RSAD1
FMN binding	POR;NOS2A;TYW1;NDOR1;NOS3;NOS1;HAO2;PNPO;MTRR
iron ion binding	HBAA;CYP51A1;CYP17A2;HBBE3;SC4MOL;FAXDC2;ALOX12;CYP2X10.2;CYP2A12
lyase activity	CAR3;CAR5A;HMGB1;ADCY1B;GUCY2E;THNSL2;Car12;POLL;AGXT2L2

TYW1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TYW1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TYW1.

htpX4

Molle, T; Kathirvelu, V; et al. Radical-SAM enzymes with two FeS clusters, RimO and TYW1: Using spectroscopy to assign the interactions and function of each cluster. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY 19:S837-S838(2014).

Young, AP; Bandarian, V; et al. Radical mediated ring formation in the biosynthesis of the hypermodified tRNA base wybutosine. CURRENT OPINION IN CHEMICAL BIOLOGY 17:613-618(2013).