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Official Full Name ubiquitin-like modifier activating enzyme 3
Background The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Synonyms UBA3; ubiquitin-like modifier activating enzyme 3; UBE1C, ubiquitin activating enzyme E1C (homologous to yeast UBA3) , ubiquitin activating enzyme E1C (UBA3 homolog, yeast); NEDD8-activating enzyme E1 catalytic subunit; hUba3; ubiquitin activating enzym
    • Species :
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human UBA3-1938H Recombinant Human Ubiquitin-Like Modifier Activating Enzyme 3, His-tagged His
    Human UBA3-254H Recombinant Human UBA3, GST-tagged Sf9 Insect Cell GST
    Human UBA3-2793H Recombinant Human UBA3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human UBA3-604HCL Recombinant Human UBA3 293 Cell Lysate HEK293 N/A
    Human UBA3-605HCL Recombinant Human UBA3 293 Cell Lysate HEK293 N/A
    Mouse Uba3-6766M Recombinant Mouse Uba3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat UBA3-6386R Recombinant Rat UBA3 Protein Mammalian Cell His
    Cynomolgus Monkey UBA3-1068C Recombinant Cynomolgus UBA3 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque UBA3-5047R Recombinant Rhesus monkey UBA3 Protein, His-tagged Mammalian Cell His
    Zebrafish UBA3-12635Z Recombinant Zebrafish UBA3 Mammalian Cell His

    uba3 involved in several pathways and played different roles in them. We selected most pathways uba3 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with uba3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ubiquitin mediated proteolysis UBE4B; UBE3B; UBE2A; PIAS1; MGRN1B; UBE2I; SOCS3; PML; SIAH1; UBE2U

    uba3 has several biochemical functions, for example, ATP binding, NEDD8 activating enzyme activity, acid-amino acid ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by uba3 itself. We selected most functions uba3 had, and list some proteins which have the same functions with uba3. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding PFKFB2A; CDC34B; TTLL6; CAMK2D1; CDK10; CKMT2B; KATNA1; STK24A; TBK1; NEK11
    NEDD8 activating enzyme activity UBA3
    acid-amino acid ligase activity UBA3; TRIM25; RNF41; RAG1
    ligand-dependent nuclear receptor binding TADA3; NCOR2; SRA1; NCOA2; TRIP4; NCOA3; SLC30A9; SMARCD3; UBA3; ARID1A
    protein binding MED24; CLTB; SCO2; SPA17; CHRAC1; EIF4E2; PTPN9; CD200; SMIM3; MACF1
    protein heterodimerization activity H3F3A; HIST1H47; KCNH5; HNF1A; DRAP1; SOX8; MPP7; NR2C2; HIST3H2A; ADRA2A

    uba3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with uba3 here. Most of them are supplied by our site. Hope this information will be useful for your research of uba3.


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