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Official Full Name ubiquitin-conjugating enzyme E2G 2
Background The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Synonyms UBE2G2; ubiquitin-conjugating enzyme E2G 2; ubiquitin conjugating enzyme E2G 2 (homologous to yeast UBC7) , ubiquitin conjugating enzyme E2G 2 (UBC7 homolog, yeast); ubiquitin-conjugating enzyme E2 G2; UBC7; ubiquitin-protein ligase G2; ubiquitin carrier
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • SUMO
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human UBE2G2-126H Recombinant Human UBE2G2 E.coli N/A
    Human UBE2G2-127H Recombinant Human UBE2G2, His6-SUMO-tagged E.coli His/SUMO
    Human UBE2G2-532H Recombinant Human UBE2G2 Protein, His-tagged E.coli His
    Human UBE2G2-577HCL Recombinant Human UBE2G2 293 Cell Lysate HEK293 N/A
    Human UBE2G2-578HCL Recombinant Human UBE2G2 293 Cell Lysate HEK293 N/A
    Human UBE2G2-7946H Recombinant Human UBE2G2, GST-tagged E.coli GST
    Human UBE2G2-99H Recombinant Human UBE2G2, His-tagged E.coli His
    Mouse UBE2G2-17717M Recombinant Mouse UBE2G2 Protein Mammalian Cell His
    Mouse Ube2g2-6788M Recombinant Mouse Ube2g2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rhesus Macaque UBE2G2-5060R Recombinant Rhesus monkey UBE2G2 Protein, His-tagged Mammalian Cell His
    Chicken UBE2G2-4823C Recombinant Chicken UBE2G2 Mammalian Cell His
    Zebrafish UBE2G2-2514Z Recombinant Zebrafish UBE2G2 Mammalian Cell His

    ube2g2 involved in several pathways and played different roles in them. We selected most pathways ube2g2 participated on our site, such as Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum, Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with ube2g2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ubiquitin mediated proteolysis UBE2G1; SYVN1; TCEB2; UBE2J1; UBE2G1A; CDC26; UBE2I; MID1; PRPF19; UBE2D1
    Protein processing in endoplasmic reticulum DNAJB1B; DNAJB1; NPLOC4; SEC61AL2; MAN1A; MAN1C1; BCAP31; HSPA2; MAP3K5; BAK1
    Parkinsons disease UBE2G2; SLC18A2; SLC25A4; SLC25A6; SLC6A3; NDUFA8; PRKACG; NDUFA11; GNAI2; UBA1

    ube2g2 has several biochemical functions, for example, ATP binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ube2g2 itself. We selected most functions ube2g2 had, and list some proteins which have the same functions with ube2g2. You can find most of the proteins on our site.

    Function Related Protein
    identical protein binding APLP1; CSK; ATXN10; FBLN1; TRADD; CALHM1; SUN2; MDM2; CXADR; NUP153
    protein binding RNH1; FXR2; PTPLAD1; TNFSF10; PNOC; CREBBP; P2RX4; DNM1; ZBTB16; PRPSAP1
    ubiquitin conjugating enzyme activity UBE2D2; UBE2D2A; UBE2J1; UBE2D4; UBE2V1; UBE2R2; UBE2B; UBE2N; UBE2A; UBE2E1
    ubiquitin protein ligase activity RNF220; LRSAM1; MYLIP; BRAP; SYVN1; UBR2; BTRC; UBE2N; G2E3; TRIM72
    ubiquitin protein ligase binding UBE2G1B; NFKBIA; EGFR; ANKRD32; TCEB2; HM13; CCDC50; MFN2; GPR19; CHEK2
    ubiquitin-protein transferase activity NLRC4; RNF5; UBE2O; TRAF4A; TRIM13; FBXW11; MIB1; TRIM36; ANKIB1; FBXO25

    ube2g2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ube2g2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ube2g2.


    Ambivero, CT; Cilenti, L; et al. Mulan E3 ubiquitin ligase interacts with multiple E2 conjugating enzymes and participates in mitophagy by recruiting GABARAP. CELLULAR SIGNALLING 26:2921-2929(2014).
    Liu, WX; Shang, YL; et al. gp78 elongates of polyubiquitin chains from the distal end through the cooperation of its G2BR and CUE domains. SCIENTIFIC REPORTS 4:-(2014).

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