UFL1

  • Official Full Name

    UFM1-specific ligase 1
  • Synonyms

    UFL1;UFM1-specific ligase 1;KIAA0776;E3 UFM1-protein ligase 1;Maxer;NLBP;novel LZAP binding protein;RCAD;Regulator of CDK5RAP3 and DDRGK1;LZAP-binding protein;novel LZAP-binding protein;RP3-393D12.1

Recombinant Proteins

  • Cynomolgus
  • Zebrafish
  • Mouse
  • Chicken
  • Rhesus macaque
  • Rat
  • Human
  • Mammalian Cells
  • HEK293
  • His
  • Non
  • Avi
  • Fc

    Involved Pathway

    UFL1 involved in several pathways and played different roles in them. We selected most pathways UFL1 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &amp,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with UFL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    presentation TRIM63,UBA5,TRIM9,FCGR1B,RNF41,RNF182,ASB2,ASB7,RNF19B,CYBA
    Adaptive Immune System CREB1B,RNF220,ASB18,CLEC2G,NA,IGLC2,NRG4,ASB14,TREM1,HUWE1
    Antigen processing: Ubiquitination &amp KLHL20,ASB18,LRR1,TRIM50,UBE2L6,TRIM63,GAN,TRIM39,UBA5,UBR1
    Class I MHC mediated antigen processing &amp ARIH2,RNF14,RNF138,CTSL2,ASB13,FBXO17,CMTM2A,RNF19B,STUB1,RNF41
    Proteasome degradation RNF144B,UBE2E3,ASB9,SPSB2,TRAF7,SH3RF1,ASB6,ASB13,CMTM2A,RNF4
    Immune System DYNC1H1,ADAR,CTSO,IgG3,LRRC41,ASB3,PRLRB,IFI16,IL1RN,WSB1

    Protein Function

    UFL1 has several biochemical functions, for example, UFM1 transferase activity,ligase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UFL1 itself. We selected most functions UFL1 had, and list some proteins which have the same functions with UFL1. You can find most of the proteins on our site.

    Function Related Protein
    protein binding GALNT2,ADD1,EIF2S1,NAGK,GPM6A,ACLY,EIF5A2,ENPP1,YWHAZ,LBR
    ligase activity UBR7,TTLL4,RNF31,ACSL1,NAPRT1,DTX3L,RC3H2,TRAF2,MARCH10,UBR2
    UFM1 transferase activity UFC1

    Interacting Protein

    UFL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UFL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of UFL1.

    PTP4A3;CASP4;CDK5RAP3;GSTK1;PHLDA3;UBE2D1;UBE2E1;UBE2D3;UBE2D2;rpoB;UBE2E3;UBE2W;UBE2D4;ssrna_ug;P

    Resources

    References

    • Tatsumi, K; Sou, YS; et al. A Novel Type of E3 Ligase for the Ufm1 Conjugation System. JOURNAL OF BIOLOGICAL CHEMISTRY 285:5417-5427(2010).
    • Zhang, YH; Zhang, MS; et al. Transcriptional Regulation of the Ufm1 Conjugation System in Response to Disturbance of the Endoplasmic Reticulum Homeostasis and Inhibition of Vesicle Trafficking. PLOS ONE 7:-(2012).

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