UGT1A10
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Official Full Name
UDP glucuronosyltransferase 1 family, polypeptide A10 -
Overview
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5 exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity on mycophenolic acid, coumarins, and quinolines. -
Synonyms
UGT1A10;UDP glucuronosyltransferase 1 family, polypeptide A10;UDP glycosyltransferase 1 family, polypeptide A10;UDP-glucuronosyltransferase 1-10;UGT1J;GNT1;UDP glucuronosyltransferase 1A10;UDP glycosyltransferase;UDPGT;UGT 1J;UGT1;UDPGT 1-10;OTTHUMP00000065196;OTTHUMP00000065197;UDP-glucuronosyltransferase 1-J;UDP-glucuronosyltransferase 1A10;UGT-1J;UGT1-10;UGT1.10
Recombinant Proteins
- Human
- E.coli
- Insect cells
- Mammalian Cells
- HEK293
- GST
- His
- Flag
- Avi
- Fc
- DDK
- Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| UGT1A10-3586H | Recombinant Human UGT1A10, GST-tagged | E.coli | Human | GST | 1-350aa | |
| RFL16034HF | Recombinant Full Length Human Udp-Glucuronosyltransferase 1-10(Ugt1A10) Protein, His-Tagged | E.coli | Human | His | Full L. Full Length of Mature Protein (26-530) |
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| UGT1A10-101H | Active Recombinant Human UGT1A10 Protein | Insect cells | Human |
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| UGT1A10-1394HFL | Recombinant Full Length Human UGT1A10 Protein, C-Flag-tagged | Mammalian Cells | Human | Flag | Full L. |
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| UGT1A10-2309H | Recombinant Human UGT1A10 Protein, His (Fc)-Avi-tagged | HEK293 | Human | Avi&Fc&His |
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| UGT1A10-2309H-B | Recombinant Human UGT1A10 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| UGT1A10-513H | Recombinant Human UGT1A10 Protein, MYC/DDK-tagged | HEK293 | Human | DDK&Myc |
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| UGT1A10-6359H | Recombinant Human UGT1A10 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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Involved Pathway
UGT1A10 involved in several pathways and played different roles in them. We selected most pathways UGT1A10 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT1A10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
UGT1A10 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by UGT1A10 itself. We selected most functions UGT1A10 had, and list some proteins which have the same functions with UGT1A10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
UGT1A10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT1A10 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT1A10.
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References
- Troberg, J; Jarvinen, E; et al. Dog UDP-Glucuronosyltransferase Enzymes of Subfamily 1A: Cloning, Expression, and Activity. DRUG METABOLISM AND DISPOSITION 43:107-118(2015).
- Wang, M; Zhu, JY; et al. Effects of co-treatment with sulforaphane and autophagy modulators on uridine 5 '-diphospho-glucuronosyltransferase 1A isoforms and cytochrome P450 3A4 expression in Caco-2 human colon cancer cells. ONCOLOGY LETTERS 8:2407-2416(2014).
