• Official Full Name

    UDP glucuronosyltransferase 1 family, polypeptide A10

  • Background

    This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5 exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity on mycophenolic acid, coumarins, and quinolines.
  • Synonyms

    UGT1A10; UDP glucuronosyltransferase 1 family, polypeptide A10; UDP glycosyltransferase 1 family, polypeptide A10; UDP-glucuronosyltransferase 1-10; UGT1J; GNT1; UDP glucuronosyltransferase 1A10; UDP glycosyltransferase; UDPGT; UGT 1J; UGT1; UDPGT 1-10; OTTHUMP00000065196; OTTHUMP00000065197; UDP-glucuronosyltransferase 1-J; UDP-glucuronosyltransferase 1A10; UGT-1J; UGT1-10; UGT1.10;
    • Type:
    • Recombinant Proteins
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Human
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect cells
    • Tag :
    • GST
    • His (Fc)
    • Avi
    • Myc
    • DDK
    • Myc|DDK
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human UGT1A10-513H Recombinant Human UGT1A10 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human UGT1A10-6359H Recombinant Human UGT1A10 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human UGT1A10-101H Recombinant Human UGT1A10 Protein Insect cells
    Human UGT1A10-3586H Recombinant Human UGT1A10, GST-tagged E.coli GST
    Human UGT1A10-2309H-B Recombinant Human UGT1A10 Protein Pre-coupled Magnetic Beads HEK293
    Human UGT1A10-2309H Recombinant Human UGT1A10 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    • UGT1A10 Related Articles
    Troberg, J; Jarvinen, E; et al. Dog UDP-Glucuronosyltransferase Enzymes of Subfamily 1A: Cloning, Expression, and Activity. DRUG METABOLISM AND DISPOSITION 43:107-118(2015).
    Wang, M; Zhu, JY; et al. Effects of co-treatment with sulforaphane and autophagy modulators on uridine 5 '-diphospho-glucuronosyltransferase 1A isoforms and cytochrome P450 3A4 expression in Caco-2 human colon cancer cells. ONCOLOGY LETTERS 8:2407-2416(2014).
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