UGT1A10
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Official Full Name
UDP glucuronosyltransferase 1 family, polypeptide A10
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Background
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5 exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity on mycophenolic acid, coumarins, and quinolines. -
Synonyms
UGT1A10; UDP glucuronosyltransferase 1 family, polypeptide A10; UDP glycosyltransferase 1 family, polypeptide A10; UDP-glucuronosyltransferase 1-10; UGT1J; GNT1; UDP glucuronosyltransferase 1A10; UDP glycosyltransferase; UDPGT; UGT 1J; UGT1; UDPGT 1-10; OTTHUMP00000065196; OTTHUMP00000065197; UDP-glucuronosyltransferase 1-J; UDP-glucuronosyltransferase 1A10; UGT-1J; UGT1-10; UGT1.10;
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | UGT1A10-513H | Recombinant Human UGT1A10 Protein, MYC/DDK-tagged | HEK293 | Myc/DDK |
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Human | UGT1A10-6359H | Recombinant Human UGT1A10 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK |
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Human | UGT1A10-101H | Recombinant Human UGT1A10 Protein | Insect cells |
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Human | UGT1A10-3586H | Recombinant Human UGT1A10, GST-tagged | E.coli | GST |
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Human | UGT1A10-2309H-B | Recombinant Human UGT1A10 Protein Pre-coupled Magnetic Beads | HEK293 |
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Human | UGT1A10-2309H | Recombinant Human UGT1A10 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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- UGT1A10 Related Articles
Troberg, J; Jarvinen, E; et al. Dog UDP-Glucuronosyltransferase Enzymes of Subfamily 1A: Cloning, Expression, and Activity. DRUG METABOLISM AND DISPOSITION 43:107-118(2015).
Wang, M; Zhu, JY; et al. Effects of co-treatment with sulforaphane and autophagy modulators on uridine 5 '-diphospho-glucuronosyltransferase 1A isoforms and cytochrome P450 3A4 expression in Caco-2 human colon cancer cells. ONCOLOGY LETTERS 8:2407-2416(2014).
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