UGT2B15 Protein


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Official Full Name UDP glucuronosyltransferase 2 family, polypeptide B15
Background This gene encodes a member of the UDP-glycosyltransferase (UDPGT) family. The UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein displays activity towards several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens.
Synonyms UGT2B15; UDP glucuronosyltransferase 2 family, polypeptide B15; UDP glycosyltransferase 2 family, polypeptide B15; UDP-glucuronosyltransferase 2B15; UGT2B8; EC; HLUG4; UDP glucuronosyltransferase 2 family polypeptide B15; UDP glucuronosyltransferase 2 family, member B15; UDP glucuronosyltransferase 2 family, member B8; UDP glucuronosyltransferase 2B15; UDP glucuronosyltransferase UGT2B15; UDP glucuronyltransferase family 2 beta 15; UDP glycosyltransferase 2 family, member B15; UDP glycosyltransferase 2B15; UDPGT 2B15; UDPGT2B15; UDPGTh 3; UDPGTH3; Uridine diphosphate glucuronosyltransferase 2 family, member B8; Uridine diphosphate glycosyltransferase 2 family, member B15; UDPGTh-3; UDP-glucuronosyltransferase 2B8; UDP-glucuronosyltransferase UGT2B15; UDP-glucuronyltransferase, family 2, beta-15; UDPGT 2B8
    • Species :
    • Human
    • Source :
    • HEK293T
    • Tag :
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human UGT2B15-1329H Recombinant Human UGT2B15 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human UGT2B15-1880HCL Recombinant Human UGT2B15 cell lysate N/A

    UGT2B15 involved in several pathways and played different roles in them. We selected most pathways UGT2B15 participated on our site, such as Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT2B15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Pentose and glucuronate interconversions UGT2B15; AKR1B10; UGP2B; GUSB; OXSR1; UGP2; Akr1b3; UGT1A2; AKR1A1B; AKR1B7
    Ascorbate and aldarate metabolism ALDH9A1A.1; ALDH2.1; UGT1A6B; UGT2B15; ALDH2; UGT1A9; UGT1A6A; UGT2A2; UGT1AB; ALDH3A2
    Steroid hormone biosynthesis HSD3B2; COMTB; CYP2C45; HSD17B8; CYP3A25; UGT1A7C; UGT2B15; CYP21A1; CYP2C55; UGT1A7
    Starch and sucrose metabolism GYS2; GPIA; AMY2A2; G6PCA.2; AMY2A; HK1; G6PC; UGT1AB; HKDC1; UGT1A4
    Retinol metabolism UGT1A2; RDH5; CYP3A25; CYP3A7-CYP3AP1; LRATA; CYP2C37; ADH1; CYP2C55; BCO1; ALDH1A1
    Porphyrin and chlorophyll metabolism UGT1A9; ALAS1; HMBSB; ALAD; UGT1A6B; HMOX2; UGT2A3; HCCS; P22; PPOX
    Metabolism of xenobiotics by cytochrome P GSTA5; GSTM; ALDH3A1; UGT2B15; UGT2A2; GSTA2; GSTM5; GSTT1; MGST1; UGT2A3
    Drug metabolism - cytochrome P UGT1A6B; GSTM6; GSTP2; GSTA5; UGT2B15; UGT1AB; UGT1A3; AOX2P; GSTT1B; GSTA
    Drug metabolism - other enzymes TPMT; UGT2A2; DPYDB; UGT2A3; UGT1A4; UGT1A7C; GMPS; GUSB; UGT2B7; UGT2B15
    Metabolic pathways RRM2B; AKR1A1B; ATP6V1F; UAP1L1; POLA1; aLA; HMBSB; KLF15; GCH2; PDHA1B
    Chemical carcinogenesis GSTA5; UGT1A4; Nat3; UGT1A7C; ARNT; CYP2C9; ALDH3B1; CYP2C50; AKR1C2; ADH1C

    UGT2B15 has several biochemical functions, for example, glucuronosyltransferase activity, NOT retinoic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT2B15 itself. We selected most functions UGT2B15 had, and list some proteins which have the same functions with UGT2B15. You can find most of the proteins on our site.

    Function Related Protein
    glucuronosyltransferase activity UGT2B3; UGT1B4; UGT5A2; UGT2A5; UGT2A6; UGT5C3; UGT1AB; UGT3A1; UGT2A3; EXT1
    NOT retinoic acid binding UGT2B7; UGT2B15; UGT1A4; UGT1A6

    UGT2B15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT2B15 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT2B15.

    Izukawa, T; Nakajima, M; et al. Quantitative Analysis of UDP-Glucuronosyltransferase (UGT) 1A and UGT2B Expression Levels in Human Livers. DRUG METABOLISM AND DISPOSITION 37:1759-1768(2009).
    Chouinard, S; Yueh, MF; et al. Inactivation by UDP-glucuronosyltransferase enzymes: The end of androgen signaling. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 109:247-253(2008).

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