UGT2B15

  • Official Full Name

    UDP glucuronosyltransferase 2 family, polypeptide B15

  • Overview

    This gene encodes a member of the UDP-glycosyltransferase (UDPGT) family. The UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein displays activity towards several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens.
  • Synonyms

    UGT2B15; UDP glucuronosyltransferase 2 family, polypeptide B15; UDP glycosyltransferase 2 family, polypeptide B15; UDP-glucuronosyltransferase 2B15; UGT2B8; EC 2.4.1.17; HLUG4; UDP glucuronosyltransferase 2 family polypeptide B15; UDP glucuronosyltransferase 2 family, member B15; UDP glucuronosyltransferase 2 family, member B8; UDP glucuronosyltransferase 2B15; UDP glucuronosyltransferase UGT2B15; UDP glucuronyltransferase family 2 beta 15; UDP glycosyltransferase 2 family, member B15; UDP glycosyltransferase 2B15; UDPGT 2B15; UDPGT2B15; UDPGTh 3; UDPGTH3; Uridine diphosphate glucuronosyltransferase 2 family, member B8; Uridine diphosphate glycosyltransferase 2 family, member B15; UDPGTh-3; UDP-glucuronosyltransferase 2B8; UDP-glucuronosyltransferase UGT2B15; UDP-glucuronyltransferase, family 2, beta-15; UDPGT 2B8;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rattus norvegicus (Rat)
  • E.coli expression system
  • HEK293
  • HEK293T
  • Mammalian cells
  • Flag
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human UGT2B15-1880HCL Recombinant Human UGT2B15 cell lysate N/A
Human UGT2B15-1329H Recombinant Human UGT2B15 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human UGT2B15-996HFL Recombinant Full Length Human UGT2B15 Protein, C-Flag-tagged Mammalian cells Flag
Human UGT2B15-2311H Recombinant Human UGT2B15 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human UGT2B15-2311H-B Recombinant Human UGT2B15 Protein Pre-coupled Magnetic Beads HEK293
Rattus norvegicus (Rat) RFL4264RF Recombinant Full Length Rat Udp-Glucuronosyltransferase 2B15(Ugt2B15) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (24-530)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

UGT2B15 involved in several pathways and played different roles in them. We selected most pathways UGT2B15 participated on our site, such as Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT2B15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Pentose and glucuronate interconversionsUGT1A6B;UGT2A3;AKR1B8;UGT1A6;UGT2B7;UGT1A3;DCXR;UGT1A7C;UGT1A7
Ascorbate and aldarate metabolismALDH9A1B;UGT1AB;UGT1A7;ALDH9A1A.1;UGT1A6;GKUP;UGT1A2;UGT1A9;RGN
Steroid hormone biosynthesisUGT5G1;CYP2D26;CYP3A25;SULT2B1;UGT1A7C;CYP2C38;UGT1A6;CYP3A65;HSD3B4
Starch and sucrose metabolismGPI;G6PCA.1;HK3;UGT2B15;UGT1A1;UGT1AB;UGT2B7;PYGB;GANC
Retinol metabolismCYP2C70;CYP2B19;RDH10;AOX2P;DGAT1;CYP2A4;UGT1A6B;RDH10A;CYP26B1
Porphyrin and chlorophyll metabolismUROD;UGT2B15;CP;EARS2;UGT1A6;HMOX2;UGT5G1;MMAB;GUSB
Metabolism of xenobiotics by cytochrome PUGT2B15;CBR3;GSTO1;CBR2;GSTT2;GSTM;UGT1A4;GSTM4;GSTM5
Drug metabolism - cytochrome PGSTP2;GSTA4;FMO6P;GSTM;UGT1A2;UGT5G1;UGT1A6A;GSTAL;UGT1AB
Drug metabolism - other enzymesUGT2A2;Ces2c;IMPDH1B;UCK2A;TYMP;XDH;DPYD;DPYS;CDA
Metabolic pathwaysFUT8A;SPAM1;PTGDS;POLR3F;ASL2;MTHFS;DTYMK;P4HA3;GALNTL5
Chemical carcinogenesisUGT1A1;UGT2A2;UGT1A4;CYP2C19;CYP2C55;GSTM6;UGT2B15;ARNT;GSTM3

UGT2B15 has several biochemical functions, for example, glucuronosyltransferase activity, NOT retinoic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT2B15 itself. We selected most functions UGT2B15 had, and list some proteins which have the same functions with UGT2B15. You can find most of the proteins on our site.

Function Related Protein
glucuronosyltransferase activityUGT5F1;UGT8;UGT1A3;B3GNT1;LARGE;UGT1B5;B3GAT3;UGT2B1;UGT1AB
NOT retinoic acid bindingUGT1A6;UGT2B7;UGT1A4;UGT2B15

UGT2B15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT2B15 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT2B15.

Research Area

Related articles

Izukawa, T; Nakajima, M; et al. Quantitative Analysis of UDP-Glucuronosyltransferase (UGT) 1A and UGT2B Expression Levels in Human Livers. DRUG METABOLISM AND DISPOSITION 37:1759-1768(2009).
Chouinard, S; Yueh, MF; et al. Inactivation by UDP-glucuronosyltransferase enzymes: The end of androgen signaling. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 109:247-253(2008).
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