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UGT2B15

Official Full Name

UDP glucuronosyltransferase 2 family, polypeptide B15
Overview

This gene encodes a member of the UDP-glycosyltransferase (UDPGT) family. The UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein displays activity towards several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens.
Synonyms

UGT2B15; UDP glucuronosyltransferase 2 family, polypeptide B15; UDP glycosyltransferase 2 family, polypeptide B15; UDP-glucuronosyltransferase 2B15; UGT2B8; EC 2.4.1.17; HLUG4; UDP glucuronosyltransferase 2 family polypeptide B15; UDP glucuronosyltransferase 2 family, member B15; UDP glucuronosyltransferase 2 family, member B8; UDP glucuronosyltransferase 2B15; UDP glucuronosyltransferase UGT2B15; UDP glucuronyltransferase family 2 beta 15; UDP glycosyltransferase 2 family, member B15; UDP glycosyltransferase 2B15; UDPGT 2B15; UDPGT2B15; UDPGTh 3; UDPGTH3; Uridine diphosphate glucuronosyltransferase 2 family, member B8; Uridine diphosphate glycosyltransferase 2 family, member B15; UDPGTh-3; UDP-glucuronosyltransferase 2B8; UDP-glucuronosyltransferase UGT2B15; UDP-glucuronyltransferase, family 2, beta-15; UDPGT 2B8;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Rattus norvegicus (Rat)

Source

E.coli expression system
HEK293
HEK293T
Mammalian cells

Tag

Flag
His
Fc
Avi
Myc
DDK
Non

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	UGT2B15-1880HCL	Recombinant Human UGT2B15 cell lysate		Non		Inquiry
Human	UGT2B15-1329H	Recombinant Human UGT2B15 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc&DDK		Inquiry
Human	UGT2B15-996HFL	Recombinant Full Length Human UGT2B15 Protein, C-Flag-tagged	Mammalian cells	Flag		Inquiry
Human	UGT2B15-2311H	Recombinant Human UGT2B15 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Human	UGT2B15-2311H-B	Recombinant Human UGT2B15 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rattus norvegicus (Rat)	RFL4264RF	Recombinant Full Length Rat Udp-Glucuronosyltransferase 2B15(Ugt2B15) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (24-530)	Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

UGT2B15 involved in several pathways and played different roles in them. We selected most pathways UGT2B15 participated on our site, such as Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT2B15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Pentose and glucuronate interconversions	DCXR;ALDH2.2;OXSR1;ALDH1B1;SORD;UGT1A4;GUSB;UGT1A7C;UGT1A7
Ascorbate and aldarate metabolism	UGT1A3;ALDH9A1;UGT1A7;UGT1AB;GULO;UGT1A1;UGT1A6B;UGT2B15;GKUP
Steroid hormone biosynthesis	UGT1A6;UGT1A7C;CYP2D26;H2-KE6;CYP2C45;HSD3B4;CYP2C55;SRD5A2;HSD17B12A
Starch and sucrose metabolism	UGT2A2;GANC;HK2;UGT1A6;SI;UGT1A6B;GAA;ENPP1;AGLA
Retinol metabolism	CYP2A12;CYP2C37;DHRS4L2;CYP1A;AOX1;RDH10;RPE65C;CYP2C55;RDH8B
Porphyrin and chlorophyll metabolism	UROS;UGT2B15;UGT2A1;UGT2A3;EARS2;UGT1AB;HMOX1A;UGT2A2;FECH
Metabolism of xenobiotics by cytochrome P	DHDHL;GSTM2;CBR2;GSTA4;UGT1AB;UGT5G1;UGT1A4;UGT1A3;ALDH3A1
Drug metabolism - cytochrome P	GSTM3;AOX2P;GSTA5;AOX1;GSTT1;FMO3;MGST1.1;UGT5G1;GSTA3
Drug metabolism - other enzymes	UGT2A2;PNAT10;IMPDH1A;Ces2e;UGT1A6A;UGT2A3;UCK2;TK2;CES1
Metabolic pathways	HPSE;UMPS;SPRA;HMGCS2;G6PCA.1;UQCR10;POLR3H;ACSBG1;HSD17B1
Chemical carcinogenesis	ADH4;ALDH3B1;CBR1;CYP2C8;GSTA5;GSTT1;ALDH3B2;MGST3;NAT1

UGT2B15 has several biochemical functions, for example, glucuronosyltransferase activity, NOT retinoic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT2B15 itself. We selected most functions UGT2B15 had, and list some proteins which have the same functions with UGT2B15. You can find most of the proteins on our site.

Function	Related Protein
glucuronosyltransferase activity	EXT2;UGT5B4;LARGE;B3GAT3;UGT5G2;UGT1A4;UGT3A2;UGT5C2;UGT2A3
NOT retinoic acid binding	UGT1A6;UGT2B7;UGT2B15;UGT1A4

UGT2B15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT2B15 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT2B15.

Research Area

Izukawa, T; Nakajima, M; et al. Quantitative Analysis of UDP-Glucuronosyltransferase (UGT) 1A and UGT2B Expression Levels in Human Livers. DRUG METABOLISM AND DISPOSITION 37:1759-1768(2009).

Chouinard, S; Yueh, MF; et al. Inactivation by UDP-glucuronosyltransferase enzymes: The end of androgen signaling. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 109:247-253(2008).