Creative BioMart to Present at Discovery on Target 2023 | Sep. 25-28, 2023 | Booth number #302 Learn More

UGT2B15

Official Full Name

UDP glucuronosyltransferase 2 family, polypeptide B15
Background

This gene encodes a member of the UDP-glycosyltransferase (UDPGT) family. The UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein displays activity towards several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens.
Synonyms

UGT2B15; UDP glucuronosyltransferase 2 family, polypeptide B15; UDP glycosyltransferase 2 family, polypeptide B15; UDP-glucuronosyltransferase 2B15; UGT2B8; EC 2.4.1.17; HLUG4; UDP glucuronosyltransferase 2 family polypeptide B15; UDP glucuronosyltransferase 2 family, member B15; UDP glucuronosyltransferase 2 family, member B8; UDP glucuronosyltransferase 2B15; UDP glucuronosyltransferase UGT2B15; UDP glucuronyltransferase family 2 beta 15; UDP glycosyltransferase 2 family, member B15; UDP glycosyltransferase 2B15; UDPGT 2B15; UDPGT2B15; UDPGTh 3; UDPGTH3; Uridine diphosphate glucuronosyltransferase 2 family, member B8; Uridine diphosphate glycosyltransferase 2 family, member B15; UDPGTh-3; UDP-glucuronosyltransferase 2B8; UDP-glucuronosyltransferase UGT2B15; UDP-glucuronyltransferase, family 2, beta-15; UDPGT 2B8;

Type:
Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species :
Human

Source :
HEK293
HEK293T

Tag :
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	UGT2B15-1880HCL	Recombinant Human UGT2B15 cell lysate		N/A	Inquiry
Human	UGT2B15-1329H	Recombinant Human UGT2B15 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK	Inquiry
Human	UGT2B15-2311H	Recombinant Human UGT2B15 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	$2,998.00 / 50ug
Human	UGT2B15-2311H-B	Recombinant Human UGT2B15 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry

Involved Pathway
Protein Function
Interacting Protein
UGT2B15 Related Articles

UGT2B15 involved in several pathways and played different roles in them. We selected most pathways UGT2B15 participated on our site, such as Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT2B15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Pentose and glucuronate interconversions	GUSB;SORD;CRYL1;UGT2A3;AKR1B8;AKR1B10;XYLB;UGT1A3;AKR1A1B
Ascorbate and aldarate metabolism	RGN;UGT1A6A;ALDH1B1;ALDH9A1;ALDH9A1A.1;UGT2A2;ALDH7A1;UGT1A7;GULO
Steroid hormone biosynthesis	CYP2D26;UGT2B7;AKR1D1;HSD17B7;HSD17B12B;HSD3B4;CYP2B19;CYP2C50;SULT2ST3
Starch and sucrose metabolism	PGM2L1;UGP2;GUSB;PYGM;UGT1A6;UGT2A2;G6PC;UXS1;UGT2A1
Retinol metabolism	RDH12;AOX3;AOX2P;CYP2C50;CYP3A65;UGT2A3;UGT1A3;CYP2C54;AOX4
Porphyrin and chlorophyll metabolism	BLVRB;ALAD;EARS2;HEPH;ALAS2;HMOX1A;HCCS;UGT2B15;HCCSA.1
Metabolism of xenobiotics by cytochrome P	MGST1.2;ALDH3B2;ALDH3B1;DHDH;UGT2A1;MGST2;HSD11B1;UGT1A2;UGT2B7
Drug metabolism - cytochrome P	MAOB;GSTM7;FMO2;ALDH3B1;UGT1A3;ALDH3B2;UGT1A1;GSTM3;GSTT1
Drug metabolism - other enzymes	UGT5G1;UPP2;DPYS;PNAT10;Ces2e;UPB1;Nat3;TYMP;IMPDH1A
Metabolic pathways	MGAT3A;EXTL2;UROS;AGXT;HSD11B1;CYP2A4;NT5C1B-RDH14;PPCS;ASAH1
Chemical carcinogenesis	CYP3A41A;MGST3;GSTA5;UGT1A2;UGT2A1;ADH7;SULT1A3;CYP3A7-CYP3AP1;CYP2C70

UGT2B15 has several biochemical functions, for example, glucuronosyltransferase activity, NOT retinoic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT2B15 itself. We selected most functions UGT2B15 had, and list some proteins which have the same functions with UGT2B15. You can find most of the proteins on our site.

Function	Related Protein
glucuronosyltransferase activity	CSGALNACT1;UGT5B2;UGT1A4;UGT2A4;UGT5A5;UGT5D1;UGT1B3;UGT1B4;EXT2
NOT retinoic acid binding	UGT1A6;UGT2B15;UGT1A4;UGT2B7

UGT2B15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT2B15 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT2B15.

Izukawa, T; Nakajima, M; et al. Quantitative Analysis of UDP-Glucuronosyltransferase (UGT) 1A and UGT2B Expression Levels in Human Livers. DRUG METABOLISM AND DISPOSITION 37:1759-1768(2009).

Chouinard, S; Yueh, MF; et al. Inactivation by UDP-glucuronosyltransferase enzymes: The end of androgen signaling. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 109:247-253(2008).