UGT2B15 Protein


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Official Full Name UDP glucuronosyltransferase 2 family, polypeptide B15
Background This gene encodes a member of the UDP-glycosyltransferase (UDPGT) family. The UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein displays activity towards several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens.
Synonyms UGT2B15; UDP glucuronosyltransferase 2 family, polypeptide B15; UDP glycosyltransferase 2 family, polypeptide B15; UDP-glucuronosyltransferase 2B15; UGT2B8; EC; HLUG4; UDP glucuronosyltransferase 2 family polypeptide B15; UDP glucuronosyltransferase 2 family, member B15; UDP glucuronosyltransferase 2 family, member B8; UDP glucuronosyltransferase 2B15; UDP glucuronosyltransferase UGT2B15; UDP glucuronyltransferase family 2 beta 15; UDP glycosyltransferase 2 family, member B15; UDP glycosyltransferase 2B15; UDPGT 2B15; UDPGT2B15; UDPGTh 3; UDPGTH3; Uridine diphosphate glucuronosyltransferase 2 family, member B8; Uridine diphosphate glycosyltransferase 2 family, member B15; UDPGTh-3; UDP-glucuronosyltransferase 2B8; UDP-glucuronosyltransferase UGT2B15; UDP-glucuronyltransferase, family 2, beta-15; UDPGT 2B8
    • Species :
    • Human
    • Rattus norvegicus (Rat)
    • Source :
    • E.coli expression system
    • HEK293T
    • Tag :
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human UGT2B15-1880HCL Recombinant Human UGT2B15 cell lysate N/A
    Rattus norvegicus (Rat) RFL4264RF Recombinant Full Length Rat Udp-Glucuronosyltransferase 2B15(Ugt2B15) Protein, His-Tagged E.coli expression system His
    Human UGT2B15-1329H Recombinant Human UGT2B15 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK

    UGT2B15 involved in several pathways and played different roles in them. We selected most pathways UGT2B15 participated on our site, such as Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT2B15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Pentose and glucuronate interconversions ALDH3A2A; GKUP; ALDH2; CRYL1; UGP2A; UGT1AB; UGP2; Akr1b3; UGT1A4; RPE
    Ascorbate and aldarate metabolism UGT1A4; GULO; ALDH9A1A.1; ALDH2.2; UGT1A6A; UGT1A1; MIOX; ALDH2.1; UGT2A2; UGDH
    Steroid hormone biosynthesis CYP2C37; HSD17B7; CYP3A65; CYP3A41B; AKR1C2; CYP19A1A; CYP3A41A; HSD17B1; AKR1D1; UGT1A6B
    Starch and sucrose metabolism UGT1A7; UGT1A2; PYGB; AMY2B; PGM1; KL; G6PCA.1; GPIA; AMY2A5; GBE1
    Retinol metabolism DHRS4L2; HSD17B6; CYP2A4; UGT1A7; ADH2-1; BCMO1; RDH12; RDH5; LRAT; CYP2C70
    Porphyrin and chlorophyll metabolism ALAD; EPRS; HMOX1; UGT2B15; BLVRB; UGT5G1; UGT1A9; ALAS1; BLVRA; GUSB
    Metabolism of xenobiotics by cytochrome P UGT1A6B; GSTA; UGT2A1; UGT1A6; UGT1A7; AKR7A3; UGT2B7; AKR7A5; GSTA1; CBR1
    Drug metabolism - cytochrome P UGT2A1; GSTM1; GSTA3; FMO4; AOX1; ALDH3B1; GSTM2; GSTA4; MGST1.2; UGT2A3
    Drug metabolism - other enzymes UGT1A7C; UGT2A3; PNAT3; CES1C; DPYDB; TPMT.1; UCK2; UGT1AB; HPRT1; UGT1A3
    Metabolic pathways KLF15; AZIN2; MTMR7B; MINPP1A; CBSB; PTGES; MTMR7A; AOX2P; PPT1; FBP1A
    Chemical carcinogenesis UGT1A1; CYP3A4; UGT1A6B; CYP2C50; GSTO1; AKR1C2; PTGS2; CYP2C37; SULT1A3; CYP2C54

    UGT2B15 has several biochemical functions, for example, glucuronosyltransferase activity, NOT retinoic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT2B15 itself. We selected most functions UGT2B15 had, and list some proteins which have the same functions with UGT2B15. You can find most of the proteins on our site.

    Function Related Protein
    glucuronosyltransferase activity UGT1A5; UGT2A5; UGT5G2; UGT1A4; UGT5A5; UGT2B7; UGT2A3; UGT1AB; UGT1B3; UGT5F1
    NOT retinoic acid binding UGT1A4; UGT2B15; UGT1A6; UGT2B7

    UGT2B15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT2B15 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT2B15.

    Izukawa, T; Nakajima, M; et al. Quantitative Analysis of UDP-Glucuronosyltransferase (UGT) 1A and UGT2B Expression Levels in Human Livers. DRUG METABOLISM AND DISPOSITION 37:1759-1768(2009).
    Chouinard, S; Yueh, MF; et al. Inactivation by UDP-glucuronosyltransferase enzymes: The end of androgen signaling. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 109:247-253(2008).

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