USP25 Protein


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Official Full Name ubiquitin specific peptidase 25
Background Ubiquitin (MIM 191339) is a highly conserved 76-amino acid protein involved in regulation of intracellular protein;breakdown, cell cycle regulation, and stress response. Ubiquitin is released from degraded proteins by disassembly of;the polyubiquitin chains, which is mediated by ubiquitin-specific proteases (USPs), such as USP25 (Valero et al., 1999;(PubMed 10644437)).
Synonyms USP25; ubiquitin specific peptidase 25; ubiquitin specific protease 25; ubiquitin carboxyl-terminal hydrolase 25; USP21; USP on chromosome 21; ubiquitin thioesterase 25; deubiquitinating enzyme 25; ubiquitin thiolesterase 25; ubiquitin-specific processing
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human USP25-187H Active Recombinant Human USP25, GST-tagged E.coli GST Inquiry
    Human USP25-3623H Recombinant Human USP25, GST-tagged E.coli GST Inquiry
    Mouse USP25-17914M Recombinant Mouse USP25 Protein Mammalian Cell His Inquiry
    Zebrafish USP25-259Z Recombinant Zebrafish USP25 Mammalian Cell His Inquiry
    Human USP25-463HCL Recombinant Human USP25 293 Cell Lysate HEK293 N/A Inquiry
    Human USP25-1051H Recombinant Human USP25 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK Inquiry
    Mouse Usp25-6872M Recombinant Mouse Usp25 Protein, Myc/DDK-tagged HEK293T Myc/DDK Inquiry

    USP25 involved in several pathways and played different roles in them. We selected most pathways USP25 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with USP25 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    USP25 has several biochemical functions, for example, ATPase binding, SUMO binding, cysteine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by USP25 itself. We selected most functions USP25 had, and list some proteins which have the same functions with USP25. You can find most of the proteins on our site.

    Function Related Protein
    ATPase binding ANK2; DRD1A; ATP6V0A1A; TCIRG1; TOR1AIP2; NOP58; UBXN1; ATXN3; FXYD1; SDF2L1
    SUMO binding PML; CBX4; TOLLIP; HERC2; USP25; TDG; USPL1; RPS3
    cysteine-type endopeptidase activity USP27X; USP44; USP6; CTSO; ATG4D; USP47; CTSLA; USP28; ATG4B; USP34
    peptidase activity TMPRSS5; Shh; PRSS52; C3orf37; LGMN; CAPN11; CTSH; PPPDE2; PRSS42; METAP2
    protein binding EHHADH; CKS1B; SERP2; KCNN4; TPRGL; VIP; ITM2C; RAD23B; TRP63; AKAP12
    ubiquitin binding VPS28; UBAP1; FAF1; FAF2; RBCK1; TSG101; TOP2A; CRY2; TOM1L1; TNFAIP3
    ubiquitin protein ligase binding ABI2; TRIM28; YWHAZ; BAG5; NPLOC4; CUL1A; GPR37; UBE2V1; CUL4B; TRAF2
    ubiquitin-specific protease activity USP17L2; USP19; USP49; OTUB1; FMNL3; USP50; USP7; YOD1; OTUD1; USP4
    ubiquitin-specific protease activity involved in negative regulation of ERAD pathway USP25

    USP25 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USP25 here. Most of them are supplied by our site. Hope this information will be useful for your research of USP25.


    Wang, L; Huang, JX; et al. Adenosylmethionine Decarboxylase 1 (AMD1)-Mediated mRNA Processing and Cell Adhesion Activated & Inhibited Transition Mechanisms by Different Comparisons Between Chimpanzee and Human Left Hemisphere. CELL BIOCHEMISTRY AND BIOPHYSICS 70:279-288(2014).
    Li, J; Tan, Q; et al. miRNA-200c inhibits invasion and metastasis of human non-small cell lung cancer by directly targeting ubiquitin specific peptidase 25. MOLECULAR CANCER 13:-(2014).

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