USP25

  • Official Full Name

    ubiquitin specific peptidase 25

  • Overview

    Ubiquitin (MIM 191339) is a highly conserved 76-amino acid protein involved in regulation of intracellular protein;breakdown, cell cycle regulation, and stress response. Ubiquitin is released from degraded proteins by disassembly of;the polyubiquitin chains, which is mediated by ubiquitin-specific proteases (USPs), such as USP25 (Valero et al., 1999;(PubMed 10644437)).
  • Synonyms

    USP25; ubiquitin specific peptidase 25; ubiquitin specific protease 25; ubiquitin carboxyl-terminal hydrolase 25; USP21; USP on chromosome 21; ubiquitin thioesterase 25; deubiquitinating enzyme 25; ubiquitin thiolesterase 25; ubiquitin-specific processing;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human USP25-187H Active Recombinant Human USP25, GST-tagged E.coli GST
Human USP25-3623H Recombinant Human USP25, GST-tagged E.coli GST C-term-280aa
Human USP25-463HCL Recombinant Human USP25 293 Cell Lysate HEK293 N/A
Human USP25-0380H Recombinant Human USP25 Protein (T2-R1055), His tagged E.coli His T2-R1055
Human USP25-1051H Recombinant Human USP25 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human USP25-0358H Recombinant Human USP25 Protein (P2-L565), GST tagged E.coli GST P2-L565
Human USP25-0357H Recombinant Human USP25 Protein (P2-L565), Tag Free E.coli No tag P2-L565
Human USP25-3499H Recombinant Human USP25 Protein (Leu171-Arg451), His tagged E.coli His Leu171-Arg451
Human USP25-5835H Recombinant Human USP25 Protein (Leu195-Arg474), N-His tagged E.coli N-His Leu195-Arg474
Human USP25-0379H Recombinant Human USP25 Protein (T2-R1055), Tag Free E.coli No tag T2-R1055
Mouse USP25-17914M Recombinant Mouse USP25 Protein Mammalian Cell His
Mouse Usp25-6872M Recombinant Mouse Usp25 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse USP25-9955M Recombinant Mouse USP25 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse USP25-9955M-B Recombinant Mouse USP25 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish USP25-259Z Recombinant Zebrafish USP25 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

USP25 involved in several pathways and played different roles in them. We selected most pathways USP25 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with USP25 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

USP25 has several biochemical functions, for example, ATPase binding, SUMO binding, cysteine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by USP25 itself. We selected most functions USP25 had, and list some proteins which have the same functions with USP25. You can find most of the proteins on our site.

Function Related Protein
ATPase bindingSLN;FXYD4;DRD1A;ANK1;PLN;ALDOB;NUFIP1;ATP6V0A1;DNAJB1
SUMO bindingRPS3;TDG;USP25;CBX4;PML;HERC2;TOLLIP;USPL1
cysteine-type endopeptidase activityUSP30;LGMN;CTSSA;PSD;CASP6;Ctsl;USP17L2;USP8;PDIA3
peptidase activityPGCP;GM5136;TMPRSS11D;MCPT2;MMP1A;CASPBL;TMPRSS13A;DHH;LTA4H
protein bindingIWS1;TMEM100;GTF2H2C_2;BIRC7;NR1H2;MAGEA6;HIST1H3H;ZFYVE27;TMEM119
ubiquitin bindingUBXN2B;SIRT2;UCHL1;KCNS1;RBCK1;HSPB1;BRAP;OTUB1B;TSG101
ubiquitin protein ligase bindingFHIT;PRDX6;MAGEA2B;PARK2;YWHAZ;SCAMP3;PIAS4;CUL3B;CBS
ubiquitin-specific protease activityOTUD1;OTUD7B;ATXN3;USP48;USP43;UFD1L;USP3;USP5;OTUD5B
ubiquitin-specific protease activity involved in negative regulation of ERAD pathway

USP25 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USP25 here. Most of them are supplied by our site. Hope this information will be useful for your research of USP25.

SYK; MAGEB4; RAD23A; SUMO2; ZNF426; TNKS2; TRAF5

Research Area

Related articles

Wang, L; Huang, JX; et al. Adenosylmethionine Decarboxylase 1 (AMD1)-Mediated mRNA Processing and Cell Adhesion Activated & Inhibited Transition Mechanisms by Different Comparisons Between Chimpanzee and Human Left Hemisphere. CELL BIOCHEMISTRY AND BIOPHYSICS 70:279-288(2014).
Li, J; Tan, Q; et al. miRNA-200c inhibits invasion and metastasis of human non-small cell lung cancer by directly targeting ubiquitin specific peptidase 25. MOLECULAR CANCER 13:-(2014).
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