USP4

  • Official Full Name

    ubiquitin specific peptidase 4 (proto-oncogene)

  • Overview

    Ubiquitinating enzymes (UBEs) catalyze protein ubiquitination, a reversible process countered by deubiquitinating enzyme (DUB) action. Five DUB subfamilies are recognized, including the USP, UCH, OTU, MJD, and JAMM enzymes. USP4 was originally identified

  • Synonyms

    USP4;ubiquitin specific peptidase 4 (proto-oncogene);ubiquitin specific protease 4 (proto oncogene) , UNP;ubiquitin carboxyl-terminal hydrolase 4;Unph;ubiquitin thioesterase 4;deubiquitinating enzyme 4;ubiquitin thiolesterase 4;ubiquitous nuclear

Recombinant Proteins

  • Human
  • Chicken
  • Mouse
  • Rat
  • E.coli
  • Insect Cells
  • Mammalian Cells
  • HEK293
  • His
  • Non
  • GST
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    USP4 involved in several pathways and played different roles in them. We selected most pathways USP4 participated on our site, such as Death Receptor Signalling,Regulation of TNFR1 signaling,Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with USP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    TNFR1-induced NFkappaB signaling pathway SHARPIN,RNF31,OTUD7B,USP2,SHRPRBCK1R
    TNFR1-induced proapoptotic signaling USP2,OTUD7B
    Death Receptor Signalling GNB2L1,TAB1,SHARPIN,USP2,TAX1BP1B,RNF31,SHRPRBCK1R,TAX1BP1,OTULINB,RBCK1
    Signal Transduction LPAR2A,CDC42EP1B,ARHGEF1A,ARHGAP24,RHOJ,KLHL12,LIN7B,NTS,DHRS4,RTKN
    TNF signaling OTULIN,SHARPIN,USP2,FAM105B,RBCK1,CLIP3,TAX1BP1B,SHRPRBCK1R,OTULINB,OTUD7B
    Regulation of TNFR1 signaling SHARPIN,OTUD7B,RBCK1,TAX1BP1,OTULIN,FAM105B,CLIP3,OTULINB,USP2,RNF31

    Protein Function

    USP4 has several biochemical functions, for example, adenosine receptor binding,cysteine-type endopeptidase activity,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by USP4 itself. We selected most functions USP4 had, and list some proteins which have the same functions with USP4. You can find most of the proteins on our site.

    Function Related Protein
    adenosine receptor binding CECR1,CECR1A
    cysteine-type endopeptidase activity USP1,CTS7,CASPBL,CASP9,USP2A,USP2,CASPB,USP6,USP27X,CASP3A
    protein binding ZMAT3,PCID2,PTPRZ1,PVRL1,PRSS3,ARPIN,RNF170,NRG1,PNMA2,PPP1R7
    metal ion binding ROR2,ETFDH,MAP3K3,GTSF1L,ATP2B1A,ZDHHC18B,ZBTB18,KLF5,ZNF157,ANTXRL
    ubiquitin-specific protease activity USP37,OTUD3,BAP1,OTUD5A,TNFAIP3,USP18,USP12A,USP34,USP33,USP5
    identical protein binding HACL1,CLDN7,HTT,KHDC1B,KCNH2,SMAD6,UGP2,PCBD1,L1CAM,BNIP2

    Interacting Protein

    USP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of USP4.

    ADORA2A;RIPK1;USP8;USP39;PRPF4;PRPF3;PPIH;EIF4E2;USP1;LSM8;ADSL

    USP4 Related Signal Pathway

    Resources

    Research Area

    Regulator of NFkB
    p53 Pathway

    References

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