USP46
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Official Full Name
ubiquitin specific peptidase 46 -
Overview
Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated;action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP46 belongs to a large family of cysteine;proteases that function as deubiquitinating enzymes (Quesada et al., 2004 (PubMed 14715245)). -
Synonyms
USP46;ubiquitin specific peptidase 46;ubiquitin specific protease 46;ubiquitin carboxyl-terminal hydrolase 46;FLJ12552;Deubiquitinating enzyme 46;FLJ11850;FLJ14283;FLJ39393;Ubiquitin carboxyl terminal hydrolase 46;Ubiquitin specific processing protease 46;Ubiquitin thioesterase 46;Ubiquitin thiolesterase 46;Ubiquitin-specific-processing protease 46;UBP46_HUMAN
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Human/Mouse
- Zebrafish
- E.coli
- Mammalian Cells
- Insect Cells
- HEK293
- GST
- His
- SUMO
- Non
- Avi
- Fc
Involved Pathway
USP46 involved in several pathways and played different roles in them. We selected most pathways USP46 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with USP46 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
USP46 has several biochemical functions, for example, protein binding,ubiquitin-specific protease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by USP46 itself. We selected most functions USP46 had, and list some proteins which have the same functions with USP46. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin-specific protease activity | USP45,USP43,EIF3F,USP12A,USP7,ZRANB1B,USP33,USP9,OTULIN,USP9X |
| protein binding | PFDN5,COPB1,XRN1,RCC1,NRBF2,OAS1,PRR16,PRLR,ZKSCAN17,UBQLN1 |
Interacting Protein
USP46 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USP46 here. Most of them are supplied by our site. Hope this information will be useful for your research of USP46.
PJA2;PHLPP1;USP12;MYL6B;IQGAP1;ALDH9A1;SET;YWHAH;DMWD;PHLPP2;WDR48;WDR20;RAD51AP1;PPP1R9B;ERP44;q9p1s2_human;EIF2AK4
Resources
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References
- Feng, AP; He, YM; et al. Expression of USP15, T beta R-I and Smad7 in psoriasis. JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES 34:415-419(2014).
- Imai, S; Kano, M; et al. Behavioral Characteristics of Ubiquitin-Specific Peptidase 46-Deficient Mice. PLOS ONE 8:-(2013).
