• Official Full Name

    ubiquitin specific peptidase 46

  • Overview

    Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated;action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP46 belongs to a large family of cysteine;proteases that function as deubiquitinating enzymes (Quesada et al., 2004 (PubMed 14715245)).
  • Synonyms

    USP46; ubiquitin specific peptidase 46; ubiquitin specific protease 46; ubiquitin carboxyl-terminal hydrolase 46; FLJ12552; Deubiquitinating enzyme 46; FLJ11850; FLJ14283; FLJ39393; Ubiquitin carboxyl terminal hydrolase 46; Ubiquitin specific processing protease 46; Ubiquitin thioesterase 46; Ubiquitin thiolesterase 46; Ubiquitin-specific-processing protease 46; UBP46_HUMAN;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Human/Mouse
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • GST
  • GST|His
  • His
  • His (Fc)
  • Avi
  • N/A
  • No tag
  • SUMO
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human USP46-456H Recombinant Human ubiquitin specific peptidase 46, His-tagged E.coli His
Human USP46-3632H Recombinant Human USP46, GST-tagged E.coli GST 1-366aa
Human USP46-5057H Recombinant Human USP46, His-tagged E.coli His
Human USP46-419H Recombinant Human USP46 Protein, GST-His-tagged E.coli GST/His
Human USP46-001HCL Recombinant Human USP46 cell lysate Insect Cell N/A
Human USP46-0383H Recombinant Human USP46 Protein (M1-E366), His/GST tagged E.coli His/GST M1-E366
Human USP46-0384H Recombinant Human USP46 Protein (M1-E366), Tag Free E.coli No tag M1-E366
Mouse USP46-17933M Recombinant Mouse USP46 Protein Mammalian Cell His
Mouse USP46-9970M Recombinant Mouse USP46 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse USP46-9970M-B Recombinant Mouse USP46 Protein Pre-coupled Magnetic Beads HEK293
Human/Mouse USP46-7344H Recombinant Human/Mouse USP46 protein Insect Cells N/A Met1-Glu366
Human/Mouse USP46-7343H Recombinant Human/Mouse USP46 protein(Met1-Glu366), -SUMO-tagged Insect Cells -SUMO Met1-Glu366
Rhesus Macaque USP46-5129R Recombinant Rhesus monkey USP46 Protein, His-tagged Mammalian Cell His
Rhesus Macaque USP46-4942R Recombinant Rhesus Macaque USP46 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque USP46-4942R-B Recombinant Rhesus Macaque USP46 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish USP46-8068Z Recombinant Zebrafish USP46 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

USP46 involved in several pathways and played different roles in them. We selected most pathways USP46 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with USP46 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

USP46 has several biochemical functions, for example, protein binding, ubiquitin-specific protease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by USP46 itself. We selected most functions USP46 had, and list some proteins which have the same functions with USP46. You can find most of the proteins on our site.

Function Related Protein
protein bindingASB13;TMEM100;NR2F2;SLC30A8;ACTG1;PTK6;RPL27A;RAB6A;ASB7
ubiquitin-specific protease activityUFD1L;USP1;USP13;ZRANB1B;FAM105B;OTUB1;USP10;VCPIP1;ATXN3L

USP46 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USP46 here. Most of them are supplied by our site. Hope this information will be useful for your research of USP46.

PJA2; PHLPP1; USP12; MYL6B; IQGAP1; ALDH9A1; SET; YWHAH; DMWD; PHLPP2; WDR48; WDR20; RAD51AP1; PPP1R9B; ERP44; q9p1s2_human; EIF2AK4

Research Area

Related articles

Feng, AP; He, YM; et al. Expression of USP15, T beta R-I and Smad7 in psoriasis. JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES 34:415-419(2014).
Imai, S; Kano, M; et al. Behavioral Characteristics of Ubiquitin-Specific Peptidase 46-Deficient Mice. PLOS ONE 8:-(2013).
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