USP50 involved in several pathways and played different roles in them. We selected most pathways USP50 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with USP50 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name |
Pathway Related Protein |
USP50 has several biochemical functions, for example, cysteine-type endopeptidase activity, ubiquitin-specific protease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by USP50 itself. We selected most functions USP50 had, and list some proteins which have the same functions with USP50. You can find most of the proteins on our site.
| Function |
Related Protein |
| cysteine-type endopeptidase activity |
CASP3A; USP51; CTSL1; USP22; MALT1; SFRP1; CASP3B; USP30; PSD; CASP6L1 |
| ubiquitin-specific protease activity |
OTUD3; USP47; USP5; USP12A; USP22; USP14; ATXN3L; USP17L5; ZRANB1; USP13 |
USP50 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USP50 here. Most of them are supplied by our site. Hope this information will be useful for your research of USP50.
IPO5; UMPS; ACADM; IGF2R; ABCD3; BSG; ALDH3A2; ABCE1; GNB2; CKAP4; SLC1A5; MTHFD1L; TUBA1A; HUWE1; DYNC2H1; NUP205; AMBRA1; LUC7L; SLC25A13; AFG3L2
Armando, I; Villar, VM; et al. Dopamine D3 receptor inhibits the ubiquitin-specific peptidase 48 to promote NHE3 degradation. FASEB JOURNAL 28:1422-1434(2014).
Bermejo, JL; Kabisch, M; et al. Exploring the association between genetic variation in the SUMO isopeptidase gene USPL1 and breast cancer through integration of data from the population-based GENICA study and external genetic databases. INTERNATIONAL JOURNAL OF CANCER 133:362-372(2013).
