VAV2
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Official Full Name
vav 2 guanine nucleotide exchange factor -
Overview
Vav proteins belong to the Dbl family of guanine nucleotide exchange factors (GEFs) for Rho/Rac small GTPases. The three identified mammalian Vav proteins (Vav1, Vav2 and Vav3) differ in their expression. Vav1 is expressed only in hematopoietic cells and -
Synonyms
VAV2;vav 2 guanine nucleotide exchange factor;vav 2 oncogene;guanine nucleotide exchange factor VAV2;VAV-2
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Chicken
- E.coli
- Mammalian Cells
- HEK293
- HEK293T
- GST
- His
- Non
- Avi
- Fc
- Flag
- DDK
- Myc
Involved Pathway
VAV2 involved in several pathways and played different roles in them. We selected most pathways VAV2 participated on our site, such as Rap signaling pathway,cAMP signaling pathway,Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with VAV2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Rap signaling pathway | SKAP1,FGF3,FGF9,ITGB2,RASGRP3,FGF2,FGF8,MAGI1,PIK3CA,FLT4 |
| Natural killer cell mediated cytotoxicity | TNFSF10,IFNA12,RAET1G,PIK3R5,PTPN11,IFNA7,IFNA4,KLRK1,RAET1D,NCR2 |
| Focal adhesion | PDGFRA,GSK3B,MYL12.1,RAPGEF1,PAK6B,ITGB5,ROCK2A,ITGA3,DIAP1,RHOAB |
| Proteoglycans in cancer | MAPK13,BRAF,CBL,HOXD10,PTPN11,PLCE1,HSPB2,ROCK2,COL21A1,MMP2 |
| B Cell Receptor Signaling Pathway | STAP1,RAP2A,NRAS,PIK3R1,CD19,GRB2,VAV3,PRKCB,PIK3CA,DOK1 |
| T cell receptor signaling pathway | PRKCQ,CD8A,NCK1,CBLC,NCK2,NFATC2,PAK6,PAK7,CD247,CD3E |
| Fc epsilon RI signaling pathway | FCER1A,RAC2,VAV1,PIK3CA,LYN,MAP2K3,RAF1,RAC3,FCER1G,PLA2G4D |
| Regulation of Actin Cytoskeleton | F2R,FGF4,PPP1CA,FGFR3,FGF20B,ACTN1,WASL,PPP1CB,RAC3,WAS |
| Fc gamma R-mediated phagocytosis | PIK3CG,FCGR3A,PIK3R1,SCIN,FCGR2B,PLCG2,PLA2G4A,ASAP1,GSN,NCF1 |
Protein Function
VAV2 has several biochemical functions, for example, Rho guanyl-nucleotide exchange factor activity,epidermal growth factor receptor binding,guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by VAV2 itself. We selected most functions VAV2 had, and list some proteins which have the same functions with VAV2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| guanyl-nucleotide exchange factor activity | DOCK7,PCP2,VAV1,RAPGEF4,DOCK4,FFAR1,RASGRP1,SBF1,RASGRP3,RIC8 |
| Rho guanyl-nucleotide exchange factor activity | PLEKHG5,ARHGEF3,C9orf100,FARP1,MCF2L,OBSCN,RASGRF2B,ARHGEF10,ITSN2,AKAP13 |
| metal ion binding | TRIM71,ITGA2,LNPB,ATP1A4,DNTT,BTR22,CYP2AA3,RNF216,DEM1,ZNF217 |
| protein binding | CAND1,RAB27A,RAD9B,PDZK1,HIST1H2BI,HIST1H2AK,MARCH10,HIP1R,NLRP12,LRPAP1 |
| epidermal growth factor receptor binding | BTC,LINGO1B,SOCS5,AREG,ARF4,CBLC,MS4A1,SNX1,HBEGFA,TNK2 |
Interacting Protein
VAV2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VAV2 here. Most of them are supplied by our site. Hope this information will be useful for your research of VAV2.
SH3BP2;TTN;TOM1L1;ERBB2;MET;AR;ERBB3;GAB1;ABI1;Mbp;PRLR
VAV2 Related Signal Pathway
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References
- Birukova, AA; Tian, YF; et al. VE-cadherin trans-interactions modulate Rac activation and enhancement of lung endothelial barrier by iloprost. JOURNAL OF CELLULAR PHYSIOLOGY 227:3405-3416(2012).
- Molli, PR; Adam, L; et al. Therapeutic IMC-C225 Antibody Inhibits Breast Cancer Cell Invasiveness via Vav2-Dependent Activation of RhoA GTPase. CLINICAL CANCER RESEARCH 14:6161-6170(2008).
