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WDR11

Official Full Name

WD repeat domain 11
Overview

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus.
Synonyms

WDR11; WD repeat domain 11; bromodomain and WD repeat domain containing 2 , BRWD2; WD repeat-containing protein 11; FLJ10506; KIAA1351; Bromodomain and WD repeat containing protein 2; Bromodomain and WD repeat domain containing 2; BRWD2; DR11; WD repeat containing protein 11; WD repeat containing protein 15; WD repeat domain 15; WDR 11; WDR15; WD repeat-containing protein 15; bromodomain and WD repeat-containing protein 2;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Rhesus Macaque

Source

HEK293
Mammalian Cell

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	WDR11-789H	Recombinant Human WDR11	Mammalian Cell	His	Inquiry
Human	WDR11-356HCL	Recombinant Human WDR11 293 Cell Lysate	HEK293	Non	Inquiry
Human	WDR11-4301H	Recombinant Human WDR11 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi	Inquiry
Human	WDR11-4301H-B	Recombinant Human WDR11 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Rhesus Macaque	WDR11-5192R	Recombinant Rhesus monkey WDR11 Protein, His-tagged	Mammalian Cell	His	Inquiry
Rhesus Macaque	WDR11-5005R	Recombinant Rhesus Macaque WDR11 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi	Inquiry
Rhesus Macaque	WDR11-5005R-B	Recombinant Rhesus Macaque WDR11 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

WDR11 involved in several pathways and played different roles in them. We selected most pathways WDR11 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with WDR11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

WDR11 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WDR11 itself. We selected most functions WDR11 had, and list some proteins which have the same functions with WDR11. You can find most of the proteins on our site.

Function	Related Protein
protein binding	UBC;SIRT7;GLP1R;NUP107;GTF2H1;VEGFA;PDCD10;PDZD11;PCSK2

WDR11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WDR11 here. Most of them are supplied by our site. Hope this information will be useful for your research of WDR11.

GABARAPL1; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; UBXN7; GABARAPL1

Research Area

Yue, MM; Lv, K; et al. Novel RNA-binding Protein P311 Binds Eukaryotic Translation Initiation Factor 3 Subunit b (eIF3b) to Promote Translation of Transforming Growth Factor beta 1-3 (TGF-beta 1-3). JOURNAL OF BIOLOGICAL CHEMISTRY 289:33971-33983(2014).

Huber, C; Wu, SL; et al. WDR34 Mutations that Cause Short-Rib Polydactyly Syndrome Type III/Severe Asphyxiating Thoracic Dysplasia Reveal a Role for the NF-kappa B Pathway in Cilia. AMERICAN JOURNAL OF HUMAN GENETICS 93:926-931(2013).