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WNK2

  • Official Full Name

    WNK lysine deficient protein kinase 2

  • Overview

    The protein encoded by this gene is a cytoplasmic serine-threonine kinase that belongs to the protein kinase superfamily. The protein plays an important role in the regulation of electrolyte homeostasis, cell signaling survival, and proliferation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
  • Synonyms

    WNK2; WNK lysine deficient protein kinase 2; PRKWNK2; NY-CO-43; SDCCAG43; P/OKcl.13; serine/threonine-protein kinase WNK2; antigen NY-CO-43; protein kinase with no lysine 2; protein kinase lysine-deficient 2; protein kinase, lysine deficient 2; serologically defined colon cancer antigen 43; mitogen-activated protein kinase kinase kinase;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human WNK2-259H Active Recombinant Human WNK2(166-489) Protein, N-His-tagged Sf21 His 166-489 aa
Mouse WNK2-18561M Recombinant Mouse WNK2 Protein Mammalian Cell His
Mouse WNK2-10188M Recombinant Mouse WNK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse WNK2-10188M-B Recombinant Mouse WNK2 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • WNK2 Related Articles

WNK2 involved in several pathways and played different roles in them. We selected most pathways WNK2 participated on our site, such as Ion channel transport, Stimuli-sensing channels, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with WNK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ion channel transportCLCN5;CLCN4-2;TRPM4C;TRPC5A;ATP1A1A.5;SGK2;CLCN2;SRI;WNK1
Stimuli-sensing channelsANO8;ANO7;TRPM4C;SLC9B2;ANO10;WNK2;ANO5;OSTM1;TRDN
Transmembrane transport of small moleculesSLC2A8;SLC47A1;SLC38A3;APOD;SLC2A15B;OSTM1;SLC6A1A;SLC39A8;LCN12

WNK2 has several biochemical functions, for example, ATP binding, kinase activity, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by WNK2 itself. We selected most functions WNK2 had, and list some proteins which have the same functions with WNK2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingDMC1;SYN2A;ACSL4;PKLR;PKN1;CBWD2;PKM2;ATP6V1B2;ABCB1A
kinase activityNLK2;SBK1;PRKCBP1L;PI4KAA;PRKAR2AA;DGKAA;MAPK8A;SPS2;ITPK1A
molecular_functionGM1987;IZUMO2;DIP2B;CRISP3;IRF2BPL;MRGPRA7;GM996;SOWAHCB;DPPA2
nucleotide bindingAKAP7;RBPMS2;TYMS;EEF2A.1;HNRNPA1B;RALYL;RBM12B;VPRBP;ADSSL
protein kinase activityCSNK1DA;AURKC;FGFR1A;PRKAB1;KITB;MAP3K10;NIM1;EGFRA;MKNK2B
protein serine/threonine kinase activityCSNK1G2B;TNIK;ERN1;ARAF;TESK2;TSSK6;GAK;DSTYK;PLK4
transferase activityGLT8D1;ALPK2;CSNK1G2B;GTDC2;WBP7;NTMT1;CKBB;PRDM9;UGT5E1

WNK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WNK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of WNK2.

Lai, JG; Tsai, SM; et al. Zebrafish WNK Lysine Deficient Protein Kinase 1 (wnk1) Affects Angiogenesis Associated with VEGF Signaling. PLOS ONE 9:-(2014).
de los Heros, P; Alessi, DR; et al. The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters. BIOCHEMICAL JOURNAL 458:559-573(2014).
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