WNK2

  • Official Full Name

    WNK lysine deficient protein kinase 2
  • Overview

    The protein encoded by this gene is a cytoplasmic serine-threonine kinase that belongs to the protein kinase superfamily. The protein plays an important role in the regulation of electrolyte homeostasis, cell signaling survival, and proliferation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
  • Synonyms

    WNK2;WNK lysine deficient protein kinase 2;PRKWNK2;NY-CO-43;SDCCAG43;P/OKcl.13;serine/threonine-protein kinase WNK2;antigen NY-CO-43;protein kinase with no lysine 2;protein kinase lysine-deficient 2;protein kinase, lysine deficient 2;serologically defined colon cancer antigen 43;mitogen-activated protein kinase kinase kinase
Cat.# Product name Source (Host) Species Tag Protein Length Price
WNK2-18561M Recombinant Mouse WNK2 Protein Mammalian Cells Mouse His
WNK2-10188M Recombinant Mouse WNK2 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
WNK2-10188M-B Recombinant Mouse WNK2 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    WNK2 involved in several pathways and played different roles in them. We selected most pathways WNK2 participated on our site, such as Ion channel transport,Stimuli-sensing channels,Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with WNK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Stimuli-sensing channels SLC17A3,TRPC4,CLIC2,TRPC4A,MCOLN2,BEST4,TRPA1A,TPCN1,TRPM1,TRPC4AP
    Ion channel transport TTYH3B,GABRR2A,CLIC2,ATP1A1A.2,ATP1A1A.4,BEST1,SCNN1D,CLCN4,TCIRG1,SGK2
    Transmembrane transport of small molecules SLC5A2,SLC24A4A,SLC9A3.2,SLC39A10,ANKHB,TRPC4AP,UNC79,FXYD7,CTNS,ATP2B3A

    Protein Function

    WNK2 has several biochemical functions, for example, ATP binding,kinase activity,molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by WNK2 itself. We selected most functions WNK2 had, and list some proteins which have the same functions with WNK2. You can find most of the proteins on our site.

    Function Related Protein
    transferase activity VPRBP,UGT2B6,PTK2AA,ACLYA,CML5,TRMT13,TNIKB,MOCOS,ELOVL7B,CKMA
    protein serine/threonine kinase activity DYRK1A,PSKH2,HIPK4,SIK3,STK32C,TGFBR1,RIPK4,CLK1,STK31,PRKCI
    nucleotide binding REV3L,RHOGC,MVDA,DNM3A,ROCK2A,ACVR1BA,NT5C3B,ORC4,STK24B,PRAC
    molecular_function C21orf2,DDX19A,UBALD2,TIMM8A2,COL5A2,GOLGA7BA,LYSMD3,TMEM51A,OR2A4,FIP1L1B
    protein kinase activity PPP1R9B,FYNA,MAP2K5,CSNK1DA,MINK1,CDC42BPB,RIPK1L,STK25A,IGF1RB,IKBKB
    kinase activity SBK1,NEK1,MAPK12A,SPS2,MARCKSB,PKMB,PSTK,IGF1RB,CSNK1DA,PKM2
    ATP binding SMC5,KIF20B,ABCG1,TOR1B,PRKX,CTPS2,PI4KB,ACVR1BA,FLJ11011L,DCLK2

    Interacting Protein

    WNK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WNK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of WNK2.

    Resources

    References

    • Lai, JG; Tsai, SM; et al. Zebrafish WNK Lysine Deficient Protein Kinase 1 (wnk1) Affects Angiogenesis Associated with VEGF Signaling. PLOS ONE 9:-(2014).
    • de los Heros, P; Alessi, DR; et al. The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters. BIOCHEMICAL JOURNAL 458:559-573(2014).

    Ask a Question for All WNK2 Products

    Required fields are marked with *

    My Review for All WNK2 Products

    Required fields are marked with *