wwp1 Protein, WW domain containing E3 ubiquitin protein ligase 1


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Official Full Name WW domain containing E3 ubiquitin protein ligase 1
Background WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. [provided by RefSeq, Jul 2008]
Synonyms WWP1; WW domain containing E3 ubiquitin protein ligase 1; AIP5; Tiul1; hSDRP1; NEDD4-like E3 ubiquitin-protein ligase WWP1; WW domain-containing protein 1; atrophin-1 interacting protein 5; atrophin-1-interacting protein 5; TGIF-interacting ubiquitin ligase 1; Nedd-4-like ubiquitin-protein ligase;
    • Species :
    • Chicken
    • Human
    • Rhesus Macaque
    • Source :
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • Flag
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human WWP1-273HCL Recombinant Human WWP1 293 Cell Lysate HEK293 N/A
    Human WWP1-31531TH Recombinant Human WWP1, FLAG-tagged Insect Cell Flag
    Human WWP1-477H Recombinant Human WWP1, GST-tagged Sf9 Insect Cell Flag
    Human WWP1-75H Recombinant Human WWP1, GST-tagged Sf9 Insect Cell GST
    Rhesus Macaque WWP1-5224R Recombinant Rhesus monkey WWP1 Protein, His-tagged Mammalian Cell His
    Chicken WWP1-1926C Recombinant Chicken WWP1 Mammalian Cell His

    wwp1 involved in several pathways and played different roles in them. We selected most pathways wwp1 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &amp, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with wwp1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adaptive Immune System CTSS; CREB1B; IGKC; STIM1B; KIF26A; PVRL2L; RAPGEF4; Siglece; MGC174152; CLTA
    Antigen processing: Ubiquitination &amp LRR1; FBXO17; TRIM9; UBE2E3; TPP2; MKRN1; FBXO3; RNF41; ARIH2; ASB17
    Proteasome degradation UBE2U; LRRC41; LRR1; TRIM39; HECTD3; ASB2; TRIM11; ASB17; IWS1; UBR2
    Class I MHC mediated antigen processing &amp HECTD3; ATG7; LRSAM1; RNF220; LTN1; RNF6; RNF25; STUB1; RNF111; CTSL2
    presentation CTSL1; RNF6; ASB13; RNF4; TRIM69; RNF25; RNF220; TRIM63; RNF19B; ATG7
    Downregulation of ERBB4 signaling WWP1
    Endocytosis MVB12B; VPS25; RHOAC; CAPZA3; GIT2A; PML; ZFP652; WIPF2B; PRKCZ; SH3GLB2B
    ErbB4 signaling events WWOX; YAP1; CBFA2T3; WWP1
    Immune System BST2; AMICA1; ASB10; ASB9; UBE2J2; RBCK1; ASB7; SIGLEC15; WASF3; TRIM29
    Ion channel transport CLCNK; TTYH3B; Ano3; SLC17A3; CLIC2; ATP2C2; ATP13A1; SLC9B2; ATP2C1; ANO7

    wwp1 has several biochemical functions, for example, ligase activity, protein binding, ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by wwp1 itself. We selected most functions wwp1 had, and list some proteins which have the same functions with wwp1. You can find most of the proteins on our site.

    Function Related Protein
    ligase activity E4F1; DTX3; TRIM23; SYVN1; TRIM27; UBR4; HECTD1; MARCH10; PARK2; RCHY1
    protein binding PPP1R2P9; SRI; ABL1; GLI1; ETL4; PRDM7; RAB11FIP2; SLX1B; CARD8; MAPK14
    ubiquitin protein ligase activity PDZRN4; FANCL; PJA1; HECW1B; RABGEF1; LTN1; TRIP12; RNF144AA; TRIM71; HECTD2
    ubiquitin-protein transferase activity FBXO11; UBE2H; TRIM13; RNF217; HECTD3; LNX2B; CNOT4B; RBBP6; FBXO2; BIRC2

    wwp1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with wwp1 here. Most of them are supplied by our site. Hope this information will be useful for your research of wwp1.

    CPSF6; SMAD3; q8wu02_human; FBXL18; TRAF4; HSP90AB1; FBXL15; PHF20L1; WASL

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