xpo1
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  • Official Full Name
  • exportin 1
  • Background
  • The protein encoded by this gene mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jul 2008]
  • Synonyms
  • XPO1; exportin 1; emb; CRM1; exp1; exportin-1; CRM1, yeast, homolog; exportin 1 (CRM1 homolog, yeast); chromosome region maintenance 1 homolog; chromosome region maintenance 1 protein homolog; exportin-1 (required for chromosome region maintenance);
Cat.#:XPO1-460HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human XPO1 Protein, His-tagged
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Cat.#:XPO1-3753HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human XPO1, GST-tagged
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Cat.#:XPO1-3754HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human XPO1, GST-tagged
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Cat.#:XPO1-6619RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat XPO1 Protein
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Cat.#:XPO1-5230RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey XPO1 Protein, His-tagged
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Cat.#:XPO1-2087CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken XPO1
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Cat.#:XPO1-5491CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken XPO1
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Cat.#:XPO1-259HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human XPO1 293 Cell Lysate
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Involved Pathway

XPO1 involved in several pathways and played different roles in them. We selected most pathways XPO1 participated on our site, such as Ribosome biogenesis in eukaryotes, RNA transport, Influenza A, which may be useful for your reference. Also, other proteins which involved in the same pathway with XPO1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ribosome biogenesis in eukaryotes
RRP7A; NXF3; GAR1; REX1; MPHOSPH10; EMG1; POP5; UTP14C; POP4; NOB1
RNA transport
EIF1AXB; EIF2S2; NUP54; KPNB1; EIF3F; PAIP1; NUP62L; TRNT1; POP4; NUP214
Influenza A
IFNA8; TLR3; MAPK13; PIK3CA; IFNA7; PIK3R1; IFNA2; OAS1; RSAD2; SOCS3
HTLV-I infection
CCND1; NFKB2; IL15; HLA-B; TLN1; VDAC3; IL2RG; PPP3R2; HLA-DMA; PRKACG
Epstein-Barr virus infection
MAP2K6; YWHAH; HSPA1B; HLA-DRB3; SPN; MAP2K4; EIF2AK1; RB1; POLR2C; HDAC5

Protein Function

XPO1 has several biochemical functions, for example, RNA binding, Ran GTPase binding, nucleocytoplasmic transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by XPO1 itself. We selected most functions XPO1 had, and list some proteins which have the same functions with XPO1. You can find most of the proteins on our site.
Function
Related Protein
Function RNA binding
Related Protein ZNF385C; NOL3; BARHL1; U2AF2A; ADARB2; AGFG1; TRNAU1APA; RBM27; ADAD1; RBM17
Function Ran GTPase binding
Related Protein NUTF2; RANBP10; IPO4; RANGRF; RANBP3; BIRC5; XPO5; XPO1; TNPO1; IPO9
Function nucleocytoplasmic transporter activity
Related Protein NUP153; NUP35; TPRB; NUP107; NUP54; TPR; NUP214; NUP160; NUP133; NUPL1
Function protein binding
Related Protein CAMK2G; CHMP6; ABI1; GIMAP5; TOR1AIP2; IFT43; ING1; RNF182; SLAMF7; APEH
Function protein domain specific binding
Related Protein HIST1H4N; RXRA; GSN; NR0B2; RUNX2; PPP3R1; HIST1H4D; STX18; RQCD1; TBL1X
Function protein transporter activity
Related Protein KPNA2; KPNB1; IPO4; AP1G2; RANBP6; RAMP3; PPIAL4A; TNPO2; KPNA5; AP2A2
Function transporter activity
Related Protein RLBP1; SLC37A4; LCN9; SLCO2B1; TTPAL; SLC25A13; SLC15A4; TAP2; HIAT1B; RBP7

Interacting Protein

XPO1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with XPO1 here. Most of them are supplied by our site. Hope this information will be useful for your research of XPO1.
YWHAZ; VCAM1; BIRC5; vpu; TGS1; HAX1; ERBB2; TP53; RCC1