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YARS2

  • Official Full Name

    tyrosyl-tRNA synthetase 2, mitochondrial

  • Overview

    This gene encodes a mitochondrial protein that catalyzes the attachment of tyrosine to tRNA(Tyr). Mutations in this gene are associated with myopathy with lactic acidosis and sideroblastic anemia type 2 (MLASA2).
  • Synonyms

    YARS2; tyrosyl-tRNA synthetase 2, mitochondrial; tyrosyl-tRNA synthetase, mitochondrial; CGI 04; FLJ13995; mt TyrRS; tyrosine tRNA ligase 2; mitochondrial; Tyrosine tRNA ligase; Tyrosyl tRNA synthetase 2, mitochondrial; TYRRS; YARS 2; tyrosine tRNA ligase 2, mitochondrial; CGI-04; MLASA2; MT-TYRRS;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human YARS2-3762H Recombinant Human YARS2, GST-tagged E.coli GST 128-477aa
Human YARS2-6783H Recombinant Human Tyrosyl-tRNA Synthetase 2, Mitochondrial, His-tagged E.coli His
Human YARS2-1944HCL Recombinant Human YARS2 cell lysate N/A
Human YARS2-601H Recombinant Human YARS2 Protein, His-tagged E.coli N-His Met1-Phe219
Human YARS2-4094H Recombinant Human YARS2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Yars2-7028M Recombinant Mouse Yars2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Yars2-602M Recombinant Mouse Yars2 Protein, His-tagged E.coli N-His Ala221-Leu472
Rat YARS2-6624R Recombinant Rat YARS2 Protein Mammalian Cell His
Rat YARS2-6280R Recombinant Rat YARS2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat YARS2-6280R-B Recombinant Rat YARS2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish YARS2-7264Z Recombinant Zebrafish YARS2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • YARS2 Related Articles

YARS2 involved in several pathways and played different roles in them. We selected most pathways YARS2 participated on our site, such as Aminoacyl-tRNA biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with YARS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Aminoacyl-tRNA biosynthesisMARS;LARS;HARS;FARSB;NARS2;FARS2;VARS;AARS;YARS2

YARS2 has several biochemical functions, for example, ATP binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by YARS2 itself. We selected most functions YARS2 had, and list some proteins which have the same functions with YARS2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingSTRC;CHD9;CCT3;PRKCB;RTCD1;AK5;CKMA;ATP2A3;ADCY8
poly(A) RNA bindingFYTTD1;SUGP1;EIF4E;FNDC3B;NXF1;RPL30;NOL11;SNW1;NOVA2
protein bindingSLC9A1;UGGT2;C10orf35;MYF5;DCTN3;TRAPPC5;ARL2;TCEB2;WDFY3
protein homodimerization activityGSTM2;MGLL;ATG7;ACCS;OSTA;GSTM1;DNTTIP1;TIGIT;CBX1
tRNA bindingEARS2;AARS;TRMT11;TRMT1L;YARS2;AIMP1;MARS;METTL1;EIF2AK4
tyrosine bindingORA1;GPR143;YARS2
tyrosine-tRNA ligase activityYARS2;MADD;YARS

YARS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with YARS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of YARS2.

FAM9B; Ybx1; CDC20; USP49; pyrK; ssdna_dtdc; ICT1; MRPL50; L1RE1

Nakajima, J; Eminoglu, TF; et al. A novel homozygous YARS2 mutation causes severe myopathy, lactic acidosis, and sideroblastic anemia 2. JOURNAL OF HUMAN GENETICS 59:229-232(2014).
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