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ZNF189

Official Full Name

zinc finger protein 189
Overview

Kruppel-like zinc finger proteins such as ZNF189 contain a conserved stretch of 7 amino acids that connects a variable;number of DNA-binding zinc finger repeats of the cys(2)his(2) (C2H2) type (summarized by Odeberg et al., 1998 (PubMed;9653648)). Approximately 30% of human Kruppel-like zinc finger proteins contain an N-terminal Kruppel-associated box;(KRAB) domain. The KRAB domain consists of approximately 75 amino acids that may be subdivided into an A box, which is;present in every KRAB domain and is essential for transcriptional repression, and a B box, which is not always;present.
Synonyms

ZNF189; zinc finger protein 189; BB131811; C430015I23Rik;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ZNF189-1991HCL	Recombinant Human ZNF189 cell lysate		Non		Inquiry
Human	ZNF189-301189H	Recombinant Human ZNF189 protein, GST-tagged	E.coli	GST	Met1-Ile150	Inquiry
Rhesus Macaque	ZNF189-5308R	Recombinant Rhesus monkey ZNF189 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	ZNF189-5121R	Recombinant Rhesus Macaque ZNF189 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Rhesus Macaque	ZNF189-5121R-B	Recombinant Rhesus Macaque ZNF189 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

ZNF189 involved in several pathways and played different roles in them. We selected most pathways ZNF189 participated on our site, such as Gene Expression, Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ZNF189 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Gene Expression	ZNF692;ZNF548;ZNF157;TSEN2;ZNF263;PRPF8;TSEN54;HENMT1;GM3258
Generic Transcription Pathway	NR5A1;ZNF599;ZNF461;MED13B;ESRRGA;ZNF222;ZNF221;ZNF740;NR0B2A

ZNF189 has several biochemical functions, for example, DNA binding, metal ion binding, transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ZNF189 itself. We selected most functions ZNF189 had, and list some proteins which have the same functions with ZNF189. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	SNAPC1;H1FX;ZBTB16;POU6F2;GATA1;ARID5B;RXRGA;ZFP668;ZNF597
metal ion binding	PLA2G4F;ZNF592;RUNX1T1;YY1A;PRKCBB;GDPD2;DNA2;FTR82;GM9524
transcription factor activity, sequence-specific DNA binding	ZFP746;DMRT3A;GTF2H2;SALL1;REL;SALL1A;HOXB7A;FOXC1;ZNF394

ZNF189 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ZNF189 here. Most of them are supplied by our site. Hope this information will be useful for your research of ZNF189.

AURKA; BUB1; KRAS; ERBB2; SRC; BRAF; MCC; CTNNA1; BMPR1A; PMS2; SMAD4; STK11; DLC1; AXIN2

Research Area

Punwani, D; Simon, K; et al. Transcription Factor Zinc Finger and BTB Domain 1 Is Essential for Lymphocyte Development. JOURNAL OF IMMUNOLOGY 189:1253-1264(2012).

Kolattukudy, PE; Niu, JL; et al. Inflammation, Endoplasmic Reticulum Stress, Autophagy, and the Monocyte Chemoattractant Protein-1/CCR2 Pathway. CIRCULATION RESEARCH 110:174-189(2012).