Virus-Like Particles (VLPs) Technology Platform

Virus-like particles (VLPs) are large particles assembled from one or several structural proteins of multiple viruses. VLPs are missing viral nucleic acids and cannot replicate autonomously. Depending on their origin and structural characteristics, VLPs can be classified into several types, including RNA viruses, DNA viruses, and chimeric viruses. VLPs have the advantages of high biosafety, structural similarity to viral particles, and stimulation of effective immune system response through the same pathway as viral particles.

VLPs have been approved for use in human vaccination techniques. A number of the more contemporarily licensed vaccines, including the human papillomavirus (HPV) and hepatitis Β (HepΒ) vaccines employ this approach. In recent years, VLPs have been used in a wide range of therapeutic, immunological, and diagnostic applications.

The VLP technology platform can be produced by a variety of host cell systems, such as insect cells, plant cells, and mammalian cells. In particular, the insect cell system has the advantage of high production efficiency and easy scale-up. The plant cell system has the advantages of green, environmentally friendly production, low cost, and rapid response to epidemics.

The mammalian cell expression system is closer to the physiological environment of human cells and has higher fidelity in protein translation, modification, and folding compared to the insect cell and plant cell systems. Therefore, VLP expressed in mammalian cells has immunogenicity and biological activity closer to that of natural viruses.

Figure 1. VLPs technology platform for the preparation of membrane proteins

Creative Biomart has accumulated extensive experience in membrane protein isolation and purification. Membrane proteins prepared by our VLPs demonstrate the correct spatial structure and complete biological activity. Our experienced scientists, well-validated VLP technology platform and state-of-the-art facilities guarantee our high-quality services. Our competitive prices and rich expertise have earned us the trust of our collaborators. If you have any questions, please contact us.

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