The Cooperation between BaroFold and Lonza for PreEMT Protein Refolding Technology
On Jan. 16, 2013, Lonza, a biological development company, and BaroFold, Inc., an innovative protein technology developer, announced a non-exclusive technology and license agreement. The technology will offer them a comprehensive toolbox for microbial recombinant protein production
In line with the agreement, Lonza will evaluate BaroFold’s PreEMT™ high pressure refolding technology for use in biological development refolding processes. Lonza’s evaluation will focus on refolding difficult to express microbial products expressed as inclusion bodies. The PreEMT™ unit will be installed for evaluation at Lonza’s microbial development and manufacturing plant in Visp, Switzerland. The agreement includes an option for Lonza to extend the platform evaluation to cGMP production analysis.
PreEMT™ is a patented technology that employs high pressure for the disaggregation and controlled refolding of recombinant proteins to their native structures at yields and efficiencies not achievable using existing technologies. PreEMT is transformative and practical for manufacturing processes and can substantially reduce the cost of manufacturing due to its increased yield and throughput at high protein concentrations. PreEMT is readily scalable and has been utilized for the cGMP production of phase 1 through phase 3 clinical material.