Dendritic Cell CD Antigen
Creative BioMart Dendritic Cell CD Antigen Product List
Available Resources for Dendritic Cell CD Antigens Research
Creative BioMart is committed to providing quality products, customized services, and personalized assistance to ensure that you have everything you need to explore the complexities of dendritic cell CD antigens.
Our comprehensive list of dendritic cell CD antigens includes dendritic cell adhesion molecules, dendritic cell co-stimulatory molecules, dendritic cell lineage markers, dendritic cell pathogen recognition/uptake molecules, and other CD antigens.
- We offer a wide range of products to support the study of dendritic cell CD antigens, including recombinant proteins, natural proteins, protein-coupled magnetic beads, cell and tissue lysates, chromatography reagents, GMP proteins, and other assay kits.
- We also provide customized services related to dendritic cell CD antigen research, such as custom antibody development, protein engineering, recombinant antigen production, and assay development services to meet specific research requirements.
- We have a wealth of resources related to dendritic cell CD antigens, such as involved pathways, protein functions, interacting proteins, related articles, research areas, and other relevant topics. These resources are invaluable for gaining insight into the molecular mechanisms and biological importance of dendritic cell CD antigens.
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About Dendritic Cell CD Antigen
Dendritic cells (DCs) are a specialized type of immune cell that plays a crucial role in the initiation and regulation of immune responses. They act as sentinels, capturing and processing antigens from pathogens or other sources, and presenting them to other immune cells, such as T cells, to initiate an immune response. The function of dendritic cells is influenced by various cell surface molecules called CD antigens, which are proteins expressed on their surface. These CD antigens can be categorized into different groups based on their roles in dendritic cell biology. Here's an introduction to each category:
Dendritic Cell Adhesion Molecules
- Dendritic cell adhesion molecules are CD antigens involved in cell adhesion and interactions with other cells or extracellular matrix components. They play a role in dendritic cell migration, tissue localization, and interactions with immune cells. Examples of dendritic cell adhesion molecules include CD11a, CD11b, CD11c, CD54, and CD50.
Dendritic Cell Co-stimulatory Molecules
- Dendritic cell co-stimulatory molecules are CD antigens that provide additional signals to T cells to enhance their activation and effector functions. They play a crucial role in regulating immune responses. Examples include CD80 (B7-1), CD86 (B7-2), and CD40. Interaction between these co-stimulatory molecules on dendritic cells and their corresponding receptors on T cells is essential for effective T cell activation.
Dendritic Cell Lineage Markers
- Dendritic cell lineage markers are CD antigens that are selectively expressed on dendritic cells and can be used to identify and distinguish them from other immune cell types. These markers are useful in characterizing dendritic cell subtypes and studying their development and function. Examples of dendritic cell lineage markers include CD11c, CD123, CD141, and CD1c.
Dendritic Cell Pathogen Recognition and Uptake Molecules
- Dendritic cell pathogen recognition and uptake molecules are CD antigens involved in recognizing and capturing pathogens or their components. These molecules can include pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs) and C-type lectin receptors (CLRs). They allow dendritic cells to detect and respond to microbial infections. Examples include TLR2, TLR4, CD209 (DC-SIGN), and CD206 (Mannose Receptor).
Other Dendritic Cell CD Antigens
- Apart from the above categories, there are numerous other CD antigens expressed on dendritic cells that play diverse roles in their biology. These antigens can have functions related to antigen presentation, immune regulation, cytokine production, and more. Examples of other dendritic cell CD antigens include CD5L, CD163, CD274 (PD-L1), IL1R1, LAMP3 (CD208), and others.
Understanding the roles and functions of these CD antigens on dendritic cells is important for unraveling the complex mechanisms involved in dendritic cell biology, immune responses, and their implications in various diseases.
Fig.1 Dendritic cells initiate anti-tumor immunity. Tumor-infiltrating dendritic cells recognize and capture tumor-associated antigens, then become mature and homing to tumor-draining lymph nodes (TDLNs) or tertiary lymphoid structures (TLS) to activate T-cells and initiate anti-tumor immunity in response to the presence of tumors. (Xiao Z, et al., 2023)
Role of Dendritic Cell CD Antigens in Diseases
Cancer
- These co-stimulatory molecules (CD80 and CD86) on dendritic cells are involved in activating T cells. In cancer, their dysregulation can lead to impaired T cell activation and tumor immune evasion. Examples: Melanoma and lung cancer.
- Expression of PD-L1 on dendritic cells and other immune cells in the tumor microenvironment suppresses T cell activity through interaction with PD-1, enabling tumor immune evasion. Examples: Melanoma, lung cancer, bladder cancer.
Autoimmune and Inflammatory Diseases
- Dysregulation of CD80/CD86 expression can result in excessive T cell activation and contribute to autoimmune diseases. Examples: Rheumatoid arthritis, systemic lupus erythematosus.
- Aberrant PD-L1 expression on dendritic cells can disrupt immune regulation and contribute to autoimmune diseases. Examples: Rheumatoid arthritis, systemic lupus erythematosus.
Infectious Diseases
- CD209 (DC-SIGN) facilitates the recognition and uptake of various pathogens by dendritic cells, influencing immune responses against infections. Examples: HIV, Ebola virus.
- TLRs (e.g., TLR1, TLR2) on dendritic cells recognize microbial components and initiate immune responses against infections. Dysregulation of TLR signaling can impact disease outcomes. Examples: Tuberculosis, sepsis.
Allergic Diseases
- CD274 (PD-L1) expression on dendritic cells can modulate immune responses in allergic diseases, inhibiting T cell activation. Examples: Asthma, allergic rhinitis.
Other Diseases
- CD163, expressed on dendritic cells, is associated with inflammation and immune dysregulation in various diseases. Examples: Systemic lupus erythematosus, rheumatoid arthritis.
- Dysregulation of IL1R1 signaling on dendritic cells contributes to inflammatory diseases. Examples: Inflammatory bowel disease, rheumatoid arthritis.
- LAMP3 (CD208) is involved in antigen presentation on dendritic cells. Altered LAMP3 expression can impact immune responses and disease progression. Examples: Melanoma, infectious diseases.
It's important to note that the roles of dendritic cell CD antigens can vary within disease types and even among different subtypes of the same disease. The examples provided represent a broad overview, and further research is needed to fully understand the specific contributions of these CD antigens in each disease context.
Fig.2 Dendritic cell therapy in cancer treatment; the state-of-the-art. Associated dendritic cell CD antigens are labeled in the figure. (Sadeghzadeh M, et al., 2020)
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Related References
- Xiao Z, Wang R, Wang X, et al. Impaired function of dendritic cells within the tumor microenvironment[J]. Frontiers in Immunology, 2023, 14: 1213629.
- Sadeghzadeh M, Bornehdeli S, Mohahammadrezakhani H, et al. Dendritic cell therapy in cancer treatment; the state-of-the-art. Life Sci. 2020;254:117580.