What is HSPB3 Protein

HSPB3, officially known as Heat Shock Protein Family B (Small) Member 3, goes by various synonyms such as CRYAC, CRYAB2, and CTPP2. This molecular entity belongs to the intriguing Heat Shock Protein (HSP) family, specifically the small HSPs. With its roots in cellular stress response, HSPB3 is a multifaceted protein with unique structural characteristics and classifications.

HSPB3 Protein Structural Characteristics and Classification

Structurally, HSPB3 stands out with its alpha-crystallin domain, a defining feature of small HSPs. This domain plays a pivotal role in chaperoning cellular proteins during stress conditions, ensuring cellular homeostasis. Recent research advances have shed light on the dynamic nature of HSPB3, highlighting its role in cellular protection and adaptation.

HSPB3 Biological Functions and Molecular Mechanisms

Delving into the biological functions of HSPB3 unveils a complex interplay within cellular machinery. This small HSP acts as a molecular chaperone, aiding in the correct folding of proteins and preventing their aggregation under stress. Its presence is particularly notable in tissues with high metabolic activity, emphasizing its crucial role in maintaining cellular integrity.

Molecular mechanisms associated with HSPB3 function include its ability to form oligomeric complexes with other proteins, thereby stabilizing cellular structures. Additionally, HSPB3 exhibits a unique anti-apoptotic function, protecting cells from programmed cell death during stress conditions. The intricate dance of molecular interactions orchestrated by HSPB3 showcases its significance in cellular survival mechanisms.

Figure 1. Schematic model showing how HSPB3 participates to myoblast differentiation. (Tiago T, et al., 2021)

HSPB3 Related Signaling Pathway

The involvement of HSPB3 in cellular signaling pathways adds another layer to its intricate role. Emerging evidence suggests its participation in the mitogen-activated protein kinase (MAPK) pathway, modulating cell proliferation and survival. Understanding the signaling intricacies of HSPB3 opens avenues for targeted therapeutic interventions in diseases where these pathways are dysregulated.

HSPB3 Related Diseases

As research progresses, the link between HSPB3 and various diseases becomes increasingly evident. Dysregulation of HSPB3 expression has been implicated in neurodegenerative disorders, cardiovascular diseases, and certain cancers. The delicate balance maintained by HSPB3 in cellular homeostasis is disrupted in these pathological conditions, underscoring its potential as a diagnostic marker and therapeutic target.

HSPB3's Applications in Biomedicine

The versatile nature of HSPB3 extends beyond its fundamental cellular functions, finding practical applications in the realm of biomedicine.

• Diagnostics Development

The unique expression patterns of HSPB3 in various diseases make it a promising candidate for diagnostic assays. Detection of altered HSPB3 levels in patient samples may serve as an early indicator of cellular stress and disease progression.

• Vaccine Development

Harnessing the immunogenic properties of HSPB3 holds potential in vaccine development. Research exploring the use of HSPB3 as a vaccine adjuvant is underway, aiming to enhance the immune response against specific pathogens.

• Therapeutics

Targeting HSPB3 for therapeutic interventions is a burgeoning field. Small molecules and biological agents that modulate HSPB3 expression or activity show promise in mitigating the impact of diseases characterized by protein misfolding and cellular stress.

Recommended Products

Cat.No.	Product Name	Species	Source (Host)	Tag
HSPB3-3625H	Recombinant Human HSPB3, His-tagged	Human	Human	His
HSPB3-5116H	Recombinant Human HSPB3 Protein, GST-tagged	Human	Wheat Germ	GST
HSPB3-2729H	Recombinant Human HSPB3 protein, His-tagged	Human	E.coli	His
HSPB3-3424H	Recombinant Human HSPB3 Protein (Met1-Lys150), N-His tagged	Human	E.coli	N-His
HSPB3-3966HF	Recombinant Full Length Human HSPB3 Protein, GST-tagged	Human	In Vitro Cell Free System	GST
HSPB3-7916M	Recombinant Mouse HSPB3 Protein	Mouse	Mammalian Cell	His
HSPB3-4363M	Recombinant Mouse HSPB3 Protein, His (Fc)-Avi-tagged	Mouse	HEK293	His (Fc)-Avi
Hspb3-3454M	Recombinant Mouse Hspb3 Protein, Myc/DDK-tagged	Mouse	HEK293T	Myc/DDK
HSPB3-2952R	Recombinant Rat HSPB3 Protein	Rat	Mammalian Cell	His
HSPB3-2607R	Recombinant Rat HSPB3 Protein, His (Fc)-Avi-tagged	Rat	HEK293	His (Fc)-Avi

Reference

• Tiago T, et al. Small heat-shock protein HSPB3 promotes myogenesis by regulating the lamin B receptor. Cell Death & Disease. 2021, 12(5): 452.