What is PLA2G12A Protein

The PLA2G12A protein, found in Homo sapiens, is encoded by the PLA2G12A gene. It was originally discovered and identified via the comparison with other known phospholipase A2, in particular by analysing its genomic DNA sequence. The gene locus of the PLA2G12A protein is assigned to chromosome 10, or, explicitly, 10q25.2, which has been known to be associated with the onset of several diseases.

The PLA2G12A protein in itself is composed of 134 amino acids and it harbors a key enzyme, phospholipase A2, which ascertains its particular function. It contains an approximately 100 amino acid domain in the N-terminal region, which encompasses a lipase-conserved domain. The protein structure allows PLA2G12A protein to perform its role efficiently as it greatly helps in catalyzing the hydrolysis of the sn-2 position of membrane glycerophospholipids.

Fig1. PLA2G12A Structure (GeneCard)

Function of PLA2G12A Protein

PLA2G12A protein plays an important enzymatic role in lipid metabolism, mainly involved in the production of lipid mediators such as arachidonic acid. The protein is also responsible for catalyzing the hydrolysis of the sn-2 position of membrane glycerophospholipids. The protein, thus, helps to regulate inflammatory responses, apoptosis, as well as cell proliferation and differentiation.

PLA2G12A Protein Related Signal Pathway

PLA2G12A, as a member of the phospholipase family, plays a crucial part in decoding cell signals. The PLA2G12A protein participates in Lipid and atherosclerosis signaling pathways. These pathways involve the degradation of phospholipids into fatty acids and lysophospholipids, processes key to understanding the mechanism of signal transduction.

PLA2G12A Protein Related Diseases

The PLA2G12A protein gene has been found to be associated with several genetic diseases, suggesting their potentially vital functions. That's because the PLA2G12A gene mutations might interfere in the catalytic activity of the phospholipase A2 enzyme, leading to the accumulation of glycerophospholipids. Hence, the diseases linked with malfunctioning of PLA2G12A protein include Leukodystrophy, mental retardation, and macrocephaly, and even metabolic diseases like obesity and diabetes. However, further research is required to consolidate these associations and establish reliable therapeutic approaches.

PLA2G12A Protein Applications in Biomedicine

PLA2G12A has a significant potentiality in Biomedicine, primarily due to its enzymatic action in lipid metabolism and its probable role in the pathophysiology of diseases. Consequently, the protein could be employed as a biomarker for diagnostics or a target for therapeutic applications. For instance, inhibiting the activity of PLA2G12A enzyme could represent a possible therapeutic approach for the treatment of obesity.

Moreover, understanding the PLA2G12A protein and its pathway could provide insights into its applications in the field of oncology. Since the protein is linked to cell proliferation and differentiation, it could develop novel treatments or preventive measures for cancers.

In conclusion, the PLA2G12A protein offers a plethora of promising possibilities for the future of research and healthcare. Although our understanding of its role and mechanisms is still nascent, current scientific efforts continue to elucidate its function that potentially can reshape our therapeutic strategies drastically. Moreover, the continuous advancement of molecular biology and genetically engineered therapies foreshadow the revolutionary improvements in the fields of genetic diseases and personalized medicine, principally credited to small yet determinant keys such as PLA2G12A protein.

Our Featured Products

Cat.No.	Product Name	Species	Source (Host)	Tag
PLA2G12A-1749H	Recombinant Human PLA2G12A, GST-tagged	Human	E.coli	GST
PLA2G12A-30734TH	Recombinant Human PLA2G12A, His-tagged	Human	E.coli	His
PLA2G12A-4792H	Recombinant Human PLA2G12A protein, His&Myc-tagged	Human	E.coli	His&Myc
PLA2G12A-207HFL	Recombinant Full Length Human PLA2G12A Protein, C-Flag-tagged	Human	Mammalian cells	Flag
PLA2G12A-1881H	Recombinant Human PLA2G12A Protein, MYC/DDK-tagged	Human	HEK293	Myc/DDK
PLA2G12A-1692H	Recombinant Human PLA2G12A Protein, His (Fc)-Avi-tagged	Human	HEK293	His (Fc)-Avi