AARS

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AARS

Official Full Name alanyl-tRNA synthetase
Background The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E.coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure.
Synonyms AARS; alanyl-tRNA synthetase; alanine--tRNA ligase, cytoplasmic; alanine tRNA ligase 1; cytoplasmic; alaRS; renal carcinoma antigen NY-REN-42; alanine tRNA ligase 1, cytoplasmic; alanyl-tRNA synthetase, cytoplasmic; CMT2N
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • E.Coli or Yeast
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human AARS-459H Recombinant Human AARS Protein (Met1-Asn968), His-tagged Insect Cell His
    Human AARS-022H Recombinant Human AARS Protein, GST-tagged Wheat Germ GST
    Human AARS-241H Recombinant Human AARS Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human AARS-26881TH Recombinant Human AARS, His-tagged HIS
    Human AARS-51H Recombinant Human Alanyl-tRNA Synthetase, His-tagged Sf9 Insect Cell His
    Human AARS-9196H Recombinant Human AARS, GST-tagged E.coli GST
    Mouse Aars-2487M Recombinant Mouse Aars, His tagged Insect Cell His
    Mouse AARS-521MCL Recombinant Mouse AARS cell lysate Insect Cell N/A
    Rat Aars-3250R Recombinant Rat Aars, His-tagged E.Coli or Yeast His
    Rat AARS-386R Recombinant Rat AARS Protein Mammalian Cell His
    Chicken AARS-1271C Recombinant Chicken AARS Mammalian Cell His
    Zebrafish AARS-3856Z Recombinant Zebrafish AARS Mammalian Cell His

    AARS involved in several pathways and played different roles in them. We selected most pathways AARS participated on our site, such as Aminoacyl-tRNA biosynthesis, Cytosolic tRNA aminoacylation, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with AARS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Aminoacyl-tRNA biosynthesis RARS; WARS2; VARS; TARS2; PET112L; NARS; WARS; GARS; FARSB; EARS2
    Cytosolic tRNA aminoacylation MADD; EEF1E1; FARSB; KARS; DARS; AARS; AIMP2; AIMP1
    Gene Expression ZNF740; ZNF354A; LAMTOR1; ZNF764; CCDC76; ZKSCAN4; ZNF490; SF3A3; GTF3AA; PHF19
    tRNA Aminoacylation AIMP1; EEF1E1; KARS; AARS; AIMP2; FARSB; WARS2; MADD; FARS2; DARS

    AARS has several biochemical functions, for example, ATP binding, alanine-tRNA ligase activity, amino acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AARS itself. We selected most functions AARS had, and list some proteins which have the same functions with AARS. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding EPHB3A; HK2; ATP6V1A; TRPV1; ABCF3; BBS10; PAPD4; ABCG2A; IRAK2; DAPK2A
    alanine-tRNA ligase activity AARSD1; AARS; AARS2
    amino acid binding GCHFR; TH; TPH1A; TPH2; AGXT; DPYS; AARS2; DDAH1; TPH1; OTC
    aminoacyl-tRNA editing activity PRORSD1; AARS; IARS2; DTD1; LARS2; DTD2; VARS; LARS; VARS2; IARS
    metal ion binding ZNF266; STAMBPA; ING5A; ZNF792; MZF1; PVALB9; ADH1; SEC23IP; ZNF567; ASPHD2
    tRNA binding YARS2; RARS; CARS; RPL35A; CTU2; AIMP1; YARS; NSUN2; EIF2AK4; TRNT1

    AARS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AARS here. Most of them are supplied by our site. Hope this information will be useful for your research of AARS.

    VCAM1; ETS1; YWHAZ; 15-deoxy-delta(12,14; ere_dna; FN1; HSP90AB1; Calml3

    Zimmerman, ES; Heibeck, TH; et al. Production of Site-Specific Antibody-Drug Conjugates Using Optimized Non-Natural Amino Acids in a Cell-Free Expression System. BIOCONJUGATE CHEMISTRY 25:351-361(2014).
    Gono, T; Kawaguchi, Y; et al. Brief Report Association of HLA-DRB1*0101/*0405 with susceptibility to anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis in the Japanese population. ARTHRITIS AND RHEUMATISM 64:3736-3740(2012).

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